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COMPLETED Phase 1

Immunotoxin Therapy in Treating Patients With Malignant Glioma

NCT00006268 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Immunotoxins can locate tumor cells and kill them without harming normal cells. This may be an effective treatment for malignant glioma. PURPOSE: Phase I/II trial to study the effectiveness of immunotoxin therapy in treating patients who have malignant glioma.

Interventions

  • PROCEDURE conventional surgery
  • BIOLOGICAL cintredekin besudotox
  • DRUG isolated perfusion

Study Locations (11)

Maryland

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore
  • Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support — Bethesda
  • National Institute of Neurological Disorders and Stroke — Bethesda

Alabama

  • University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham

Florida

  • H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa

Georgia

  • Winship Cancer Institute of Emory University — Atlanta

Massachusetts

  • Massachusetts General Hospital Cancer Center — Boston

Michigan

  • Josephine Ford Cancer Center at Henry Ford Health System — Detroit

North Carolina

  • Comprehensive Cancer Center at Wake Forest University — Winston-Salem

Pennsylvania

  • Abramson Cancer Center at the University of Pennsylvania — Philadelphia

Trial Details

FieldValue
Start Date 2000-10
Est. Completion 2005-03
Phase Phase 1

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00006268

The ClinicalTrials.gov registry entry for NCT00006268 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. An enrollment target was not published in the registry record, which is common for early-stage or observational entries. The listed sponsor is New Approaches to Brain Tumor Therapy Consortium, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Brain and Central Nervous System Tumors appearing as the primary indexed condition, and to 3 interventions — of which conventional surgery is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00006268 reports 11 study locations spanning 9 distinct geographic areas — top geographies include Maryland, Alabama, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00006268 about?

NCT00006268 is a clinical study titled "Immunotoxin Therapy in Treating Patients With Malignant Glioma". RATIONALE: Immunotoxins can locate tumor cells and kill them without harming normal cells. This may be an effective treatment for malignant glioma. PURPOSE: Phase I/II trial to study the effectiveness of immunotoxin therapy in treating patients who have malignant glioma.

What is the current status of trial NCT00006268?

This trial is currently completed. It is a Phase 1 study. The study started on 2000-10. Estimated completion is 2005-03.

What conditions does trial NCT00006268 study?

This clinical trial studies the following conditions: Brain and Central Nervous System Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00006268?

The interventions under investigation include: conventional surgery (PROCEDURE), cintredekin besudotox (BIOLOGICAL), isolated perfusion (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00006268?

This trial is sponsored by New Approaches to Brain Tumor Therapy Consortium, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00006268 being conducted?

This trial has 11 study locations across Alabama, Florida, Georgia, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial