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NCT00003462 · ClinicalTrials.gov registry record · Phase 1

Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors

A Phase 1 study of Brain and Central Nervous System Tumors, sponsored by Duke University.

Completed
Registry status
Phase 1
Development phase
20
Enrollment target
1
Study location

NCT00003462: Completed Phase 1 study of Brain and Central Nervous System Tumors, sponsored by Duke University.

NCT00003462 is a Phase 1 study of Brain and Central Nervous System Tumors that has completed, run by Duke University. The registered enrollment target is 20 participants, below the 183-participant average among 45 other Brain and Central Nervous System Tumors trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00003462, a Phase 1 study of Brain and Central Nervous System Tumors, has completed, sponsored by Duke University.

COMPLETED
Registry status
Phase 1
Development phase
20 participants
Enrollment target
1
Study location

Study Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs into the thin space between the lining of the spinal cord and brain may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of intrathecal busulfan in treating patients with recurrent, refractory, or metastatic leptomeningeal tumors.

Conditions Studied

Brain and Central Nervous System Tumors

Interventions

  • DRUG busulfan

Study Locations (1)

North Carolina

  • Duke Comprehensive Cancer Center - Durham

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 1998-04
Est. Completion 2001-02
Phase Phase 1
Duke University

1,725 total trials

What the finished NCT00003462 record still lists

NCT00003462 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 183-participant average among 45 other Brain and Central Nervous System Tumors trials with a reported enrollment target (89% lower).

The record links to 1 condition, with Brain and Central Nervous System Tumors appearing as the primary indexed condition, and to 1 intervention - of which busulfan is the first listed.

NCT00003462 reports a single indexed study location in North Carolina.

Frequently Asked Questions

What is clinical trial NCT00003462 about?

NCT00003462 is a clinical study titled "Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors". RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs into the thin space between the lining of the spinal cord and brain may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of intrathecal busulf...

What is the current status of trial NCT00003462?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 1998-04. Estimated completion is 2001-02.

What conditions does trial NCT00003462 study?

This clinical trial studies the following conditions: Brain and Central Nervous System Tumors.

What interventions are being tested in trial NCT00003462?

The interventions under investigation include: busulfan (DRUG).

Who is sponsoring clinical trial NCT00003462?

This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00003462 being conducted?

This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Brain and Central Nervous System Tumors

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00003462's enrollment target sits among peer trials

20 36th of 45 higher than 9 of 45 other Brain and Central Nervous System Tumors trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Brain and Central Nervous System Tumors trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT00003462, the US trial registry maintained by the National Library of Medicine. NCT00003462 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.