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COMPLETED Phase 3

SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme

NCT00003293 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether SU-101 is more effective than procarbazine in treating patients with glioblastoma multiforme. PURPOSE: Randomized phase III trial to compare the effectiveness of SU-101 with that of procarbazine in treating patients with glioblastoma multiforme that has recurred.

Interventions

  • DRUG leflunomide
  • DRUG procarbazine hydrochloride

Study Locations (20)

California

  • USC/Norris Comprehensive Cancer Center — Los Angeles
  • Jonsson Comprehensive Cancer Center, UCLA — Los Angeles
  • Beckman Research Institute, City of Hope — Los Angeles
  • St. Francis Hospital — San Francisco

Arizona

  • St. Joseph's Hospital and Medical Center — Phoenix
  • Arizona Cancer Center — Tucson

Florida

  • Mount Sinai Comprehensive Cancer Center — Miami Beach
  • H. Lee Moffitt Cancer Center and Research Institute — Tampa

Massachusetts

  • Beth Israel Deaconess Medical Center — Boston
  • University of Massachusetts Memorial Medical Center — Worcester

Michigan

  • University of Michigan Comprehensive Cancer Center — Ann Arbor
  • Henry Ford Hospital — Detroit

New York

  • Cancer Center of Albany Medical Center — Albany
  • Memorial Sloan-Kettering Cancer Center — New York

Colorado

  • University of Colorado Cancer Center — Denver

Georgia

  • Medical College of Georgia Hospital and Clinics — Augusta

Trial Details

FieldValue
Start Date 1998-02
Est. Completion 2001-05
Phase Phase 3

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00003293

The ClinicalTrials.gov registry entry for NCT00003293 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. An enrollment target was not published in the registry record, which is common for early-stage or observational entries. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Brain and Central Nervous System Tumors appearing as the primary indexed condition, and to 2 interventions — of which leflunomide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00003293 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Arizona, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00003293 about?

NCT00003293 is a clinical study titled "SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme". RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether SU-101 is more effective than procarbazine in treating patients with glioblastoma multiforme. PURPOSE: Randomized phase III trial to compare the effect...

What is the current status of trial NCT00003293?

This trial is currently completed. It is a Phase 3 study. The study started on 1998-02. Estimated completion is 2001-05.

What conditions does trial NCT00003293 study?

This clinical trial studies the following conditions: Brain and Central Nervous System Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00003293?

The interventions under investigation include: leflunomide (DRUG), procarbazine hydrochloride (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00003293?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00003293 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial