St. Jude Children's Research Hospital

441 total trials 346 currently recruiting 41 completed

Trial Pipeline

RECRUITING Phase 2

Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors

NCT06528691

RECRUITING

Stakeholders of Rare Diseases Informing Values In Neuroethics

NCT07314736

RECRUITING

A Longitudinal Photo-Narrative Exploration of Hope During Phase 1/2 Clinical Trials For Pediatric Cancer

NCT07444216

RECRUITING Phase 1

CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma

NCT07257419

RECRUITING NA

Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia

NCT07191119

RECRUITING NA

Evaluation Of Cardiovascular Health Outcomes Among Survivors 2

NCT07245420

RECRUITING

CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation

NCT07085325

RECRUITING Phase 1

Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas

NCT07222735

RECRUITING

Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

NCT06579469

RECRUITING Phase 1

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

NCT07226219

RECRUITING Phase 2

A Phase II Study With a Safety Run-In of the Addition of N-803 to a Chemoimmunotherapy Backbone for the Treatment of Patients With Relapsed or Refractory Neuroblastoma

NCT07085338

RECRUITING

Exploring the Physiologic, Pharmacodynamic, and Clinical Responses of Skeletal Muscle in Patients With Spinal Muscular Atrophy Treated With SMN-Directed Therapies

NCT06532474

RECRUITING

CAR T-cell Long-Term Follow-Up, Quality of Life and Adverse Reactions

NCT07048535

RECRUITING Phase 1

TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies

NCT07052370

RECRUITING Early Phase 1

Positron Emission Tomography (PET) Contrast Agent Kinetics and Safety: [18F]-Fluoromannitol

NCT07110519

RECRUITING NA

Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial

NCT07160621

RECRUITING NA

Seminar in Unwavering Empowering Presence Optimized for Rehabilitation Teams

NCT07071116

RECRUITING Phase 1

Feasibility, Safety, and Potential Efficacy of Fecal Microbiota Transplantation (FMT) for Gastrointestinal Dysfunction in Children Following Hematopoietic Cell Transplant (HCT).

NCT05664113

RECRUITING

Long Term Follow-Up Study for Individuals With Hemoglobin Disorders After Hematopoietic Cell Transplant or Gene Therapy

NCT06646640

RECRUITING NA

Revealing Information Genuinely & Honestly Across Time - Communication Preferences Visit

NCT06993688

RECRUITING NA

Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors

NCT06819475

RECRUITING Phase 1

A Prospective Trial of Dalbavancin-Based Prophylaxis in Children and Adolescents With High-Risk Leukemia

NCT06810583

RECRUITING Phase 2

CAR T CELL Therapy for Pediatric, Adolescent and Young Adult Patients With CD19-Positive Leukemia

NCT06847269

RECRUITING Phase 1

CD19-CD22-Bispecific Chimeric Antigen Receptor (CAR) T Cell Therapy for Pediatric Patients With Acute Lymphoblastic Leukemia

NCT06777979

RECRUITING NA

School Readiness Intervention for Preschool Children With Sickle Cell Disease

NCT06367192

RECRUITING Phase 1

Gene Editing For Sickle Cell Disease

NCT06506461

RECRUITING NA

Assessment of Remote Approaches for Identification of Autonomic Dysfunction Among Survivors of Leukemia and Lymphoma

NCT06747910

RECRUITING Phase 2

Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma

NCT06533748

RECRUITING Phase 2

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

NCT06390319

RECRUITING Phase 4

Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

NCT06289673

RECRUITING Phase 1

SCD Stem Cell Mobilization and Apheresis Using Motixafortide

NCT06442761

RECRUITING

Feasibility of Screening for Early Late Effects of Contemporary Therapy in High-Risk Neuroblastoma Survivors

NCT06480526

RECRUITING Phase 1

CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological Malignancies

NCT06326463

RECRUITING

Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease

NCT06477289

RECRUITING

Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors

NCT06421987

RECRUITING Phase 1

Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

NCT06177067

RECRUITING

Patient-Reported Outcomes and Quality of Life in Adult and Pediatric Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)

NCT06098430

RECRUITING Phase 1

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

NCT06239272

RECRUITING Phase 2

Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease

NCT06023641

RECRUITING Phase 1

Study of CD19-directed Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia

NCT04881240

RECRUITING

Barriers and Facilitators of Parent-Child Communication in Children With Cancer Predisposition

NCT05849155

RECRUITING Early Phase 1

Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors

NCT05645523

RECRUITING Phase 2

Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET

NCT05583721

RECRUITING NA

Implementing an Adolescent and Young Adult (AYA) mHealth Vaping Cessation Program Into Oncology Clinics

NCT05967585

RECRUITING NA

Writing Intervention With Adolescents and Young Adults With Cancer

NCT05975333

RECRUITING Phase 2

Haplo-identical Viral-Specific T-cells for Treatment of Cytomegalovirus and Adenovirus Infections After Hematopoietic Cell Transplantation

NCT05664126

RECRUITING NA

Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors

NCT05947045

RECRUITING

Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)

NCT05810181

RECRUITING Phase 1

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT05835687

RECRUITING

Characterizing Sleep Among Long-term Survivors of Childhood Cancer

NCT05480904

RECRUITING

Childhood Cancer Survivors' Affective Response to Exercise

NCT05763290

RECRUITING

Long-term Follow-up After Adoptive Transfer of Genetically Modified Cell Products

NCT05713214

RECRUITING Phase 2

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

NCT05535166

RECRUITING Phase 1

Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients

NCT05468359

RECRUITING

Response to Influenza Vaccination in Pediatric Oncology Patients

NCT05384288

RECRUITING

The Decision To Enroll In Therapeutic Clinical Trials In A Pediatric Cancer Clinical Network

NCT05454618

RECRUITING

Discarded Bone Marrow for Hematology Research

NCT04671212

RECRUITING Phase 1

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

NCT04897321

RECRUITING Phase 2

Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation

NCT04968990

RECRUITING Phase 1

SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma

NCT04923126

RECRUITING Phase 1

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

NCT04901702

RECRUITING NA

Study Of Cold Cap Therapy For Prevention of Hairloss in Pediatric Patients Receiving Chemotherapy For Non-Malignant Indications and Solid Tumors

NCT04764357

RECRUITING Phase 2

Haploidentical HCT for Severe Aplastic Anemia

NCT04558736

RECRUITING

Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders

NCT04416178

RECRUITING Phase 1

Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase

NCT04195347

RECRUITING Phase 1

CD123-Directed T-Cell Therapy for Acute Myelogenous Leukemia (CATCHAML)

NCT04318678

RECRUITING

Risk Factors, Clinical Characteristics and Outcomes of Acute Infection With Coronavirus 2019 (COVID-19) In Children

NCT04371315

RECRUITING Phase 1

Indocyanine Green (ICG) Guided Tumor Resection

NCT04084067

RECRUITING NA

Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

NCT04065776

RECRUITING NA

Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease

NCT03353584

RECRUITING

Familial Investigations of Childhood Cancer Predisposition

NCT03050268

RECRUITING

Investigation of the Genetics of Hematologic Diseases

NCT02720679

RECRUITING

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

NCT02775643

RECRUITING

Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients

NCT02530658

RECRUITING

Sickle Cell Clinical Research and Intervention Program

NCT02098863

RECRUITING

Molecular Analysis Of Solid Tumors

NCT01050296

RECRUITING

Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility

NCT01354002

RECRUITING

Establishment of a Lifetime of Cohort of Adults Surviving Childhood Cancer

NCT00760656

RECRUITING

International Pediatric Adrenocortical Tumor Registry

NCT00700414

RECRUITING

Protocol For Collecting Data On Patients With Childhood Cancer

NCT00684580

RECRUITING

Pharmacogenetic Determinants Of Treatment Response In Children

NCT00730678

RECRUITING

Childhood Cancer Survivor Study

NCT01120353

ACTIVE NOT RECRUITING NA

Complementary Behavioral Interventions To Remediate Cognitive Impairment or Emotional Distress in Cancer Survivors

NCT06989463

ACTIVE NOT RECRUITING

Remote Exercise Video Adaptations to Maximize Physical Activity in Childhood Cancer

NCT06411704

ACTIVE NOT RECRUITING NA

Mindfulness Interventions to Improve Health Activation, Coping, and Stress Among Childhood Cancer Survivors

NCT06053268

ACTIVE NOT RECRUITING NA

Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis

NCT05930418

ACTIVE NOT RECRUITING

Patient- Generated Health Data to Predict Childhood Cancer Survivorship Outcomes

NCT05342155

ACTIVE NOT RECRUITING Phase 2

Study of CPX-351 (VYXEOS) in Individuals < 22 Years With Secondary Myeloid Neoplasms

NCT05656248

ACTIVE NOT RECRUITING NA

Use of Transcranial Photobiomodulation to Improve Cognition and Self-Reported Outcomes in Survivors of Childhood Cancer

NCT05550948

ACTIVE NOT RECRUITING

An Evaluation of Concordance of Smartwatch ECG and One Clinical ECG and Comparison of The Two ECGS in Terms of Predictive Risks

NCT05617391

ACTIVE NOT RECRUITING Phase 1

Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax

NCT05192889

ACTIVE NOT RECRUITING Phase 2

Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study

NCT05128903

ACTIVE NOT RECRUITING

Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients

NCT05164016

ACTIVE NOT RECRUITING Phase 2

An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer

NCT04733534

ACTIVE NOT RECRUITING Phase 2

An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer

NCT04742751

ACTIVE NOT RECRUITING Phase 1

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

NCT04898894

ACTIVE NOT RECRUITING Phase 1

Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)

NCT03597594

ACTIVE NOT RECRUITING Phase 1

Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis

NCT04551131

ACTIVE NOT RECRUITING NA

Telehealth Based Intervention to Improve Functional Capacity in Survivors of Childhood Cancer With Significantly Limited Exercise Tolerance

NCT04714840

ACTIVE NOT RECRUITING

Social Experiences of Adolescents and Young Adults With Cancer

NCT04328350

Phase Distribution

PhaseTrial count
Phase 1 154
Phase 2 39
Phase 3 2
Phase 4 1

What the Pipeline for St. Jude Children's Research Hospital Shows

According to the ClinicalTrials.gov registry, St. Jude Children's Research Hospital is linked to 441 US clinical trials across every stage of research activity. Of those, 346 studies are currently recruiting — about 78% of the sponsor's indexed portfolio — and 41 are already marked complete, representing roughly 9% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for St. Jude Children's Research Hospital reports 3 late-stage studies (Phase 3 and Phase 4 combined) and 193 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for St. Jude Children's Research Hospital is Sickle Cell Disease with 17 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial