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Essential Tremor: early-phase trial registry
24 of 42 indexed Essential Tremor trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #347 of 28,707 conditions by registered trial count.
42 US clinical trials · 24 currently recruiting · #347 of 28,707 conditions by registered trial count
Essential Tremor: 42 US clinical trials tracked, 24 recruiting.
Essential Tremor is the subject of 42 registered US clinical trials on ClinicalTrials.gov, 24 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 5 of these trials.
Enrollment posture brief
Registry condition essential-tremor
OPEN 24 | RECR 57% | LATE 0 | EARLY 4 | RANK #347 | SPON 5
Volume-matched condition peers
Nearest open-share peer: ACL (57% recruiting · 7 trials)
Essential Tremor lists 24 open slots (57% of 42 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Essential Tremor on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Essential Tremor is recruiting above its size-band peers.
24 of 42 indexed trials (57.1%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Essential Tremor trials is spread across many organizations.
University of Florida accounts for 5 of 42 trials (11.9%). 29 distinct sponsors appear on at least one study for this condition label.
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Most Essential Tremor trials plan to enrol fewer than 100 people.
Median target enrolment is 63 among the 42 trials that report a genuine target (sentinel values excluded). 27 of those (64.3%) plan for fewer than 100 participants.
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Essential Tremor research is mostly interventional.
31 interventional and 11 observational studies make up this index (73.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
42 total, page 1 of 1
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
Boston Scientific Corporation
NCT03664609
Physiological Brain Atlas Development
Vanderbilt University Medical Center
NCT00575081
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
Abbott Medical Devices
NCT04071847
Clinical Outcomes for Deep Brain Stimulation
Washington University School of Medicine
NCT03992625
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
Massachusetts Eye and Ear Infirmary
NCT05317390
Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease
CND Life Sciences
NCT07428447
Deep Brain Stimulation Surgery for Movement Disorders
National Institute of Neurological Disorders and Stroke (NINDS)
NCT01581580
Sensory-specific Peripheral Stimulation for Tremor Management
Shirley Ryan AbilityLab
NCT04501133
Attention and Eye Movement in Parkinson's Disease
University of Nebraska
NCT06899022
Motor Network Physiology
University of Texas Southwestern Medical Center
NCT04957095
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
Boston University Charles River Campus
NCT07455760
Home Use Study of Targeted Mechanical Stimulation for Tremor Relief
Encora
NCT07078422
Cortical-Basal Ganglia Speech Networks
Massachusetts General Hospital
NCT04286308
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
Northwell Health
NCT04758624
Ultrasound Neuromodulation in Essential Tremor
University of California, San Francisco
NCT06610877
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
Vanderbilt University Medical Center
NCT01734122
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
The Cleveland Clinic
NCT06293638
Circadian Adaptive DBS in Essential Tremor
University of Florida
NCT06635811
Algorithms for Programming DBS Systems for ET
University of Minnesota
NCT03984643
3-D Tractography FUS Ablation for Essential Tremor
University of North Carolina, Chapel Hill
NCT06331052
Directional Versus Nondirectional DBS for ET
Oregon Health and Science University
NCT04828798
Coordinated Reset Deep Brain Stimulation for Essential Tremor
University of Minnesota
NCT05897775
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
The Cleveland Clinic
NCT07049003
Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor
University of Florida
NCT04212780
Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:
InSightec
NCT03100474
Assessment of the Safety and Efficacy of the Felix NeuroAI Wristband in Essential Tremor
Fasikl
NCT06235190
Bilateral Treatment of Medication Refractory Essential Tremor
InSightec
NCT04112381
RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease
University of Alabama at Birmingham
NCT03305588
Impact of Sensory Electrical Stimulation on Sensation and Tremor
Shirley Ryan AbilityLab
NCT06428526
Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy
Vibhor Krishna
NCT03560622
Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study
Mayo Clinic
NCT03778060
Responsive Deep Brain Stimulator for Essential Tremor
University of Florida
NCT02649166
A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)
Jazz Pharmaceuticals
NCT05122650
Prospective Study for Symptomatic Relief of ET With Cala Therapy
Cala Health
NCT03597100
Compare Rates of Agreement Between Clinical Diagnosis and Visual Assessment of DaTscan™ Images in Non-Caucasian and Caucasian Subjects With Parkinson's Disease (PD) or Essential Tremor (ET)
GE Healthcare
NCT01952678
ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors
InSightec
NCT01827904
Brain Networks and Consciousness
University of Texas Southwestern Medical Center
NCT04502550
The Effectiveness of Alternating Stimulation in Preventing Tolerance in Essential Tremor Patients
Oregon Health and Science University
NCT02947841
Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00102596
The Motor Network in Essential Tremor: Mechanisms of Therapy
University of Florida
NCT02712515
Physiology, Imaging and Modeling of Essential Tremor
University of Florida
NCT03811405
Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation
North Carolina State University
NCT05308368
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Essential Tremor records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Essential Tremor trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Essential Tremor page
42 registered trials, 24 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 24 Essential Tremor trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Essential Tremor trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Essential Tremor condition card totals 42 registered trials; most-linked intervention Deep Brain Stimulation; top US site state Florida. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.