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Dry Eye clinical trials
9 of 42 indexed Dry Eye trials are currently recruiting.
42 US clinical trials · 9 currently recruiting
Dry Eye is the subject of 42 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Toyos Clinic, running 3 of these trials.
The research picture
Dry Eye has 42 registered US clinical trials, 9 of them open to new participants right now, about 21% of the total.
- 9
- recruiting participants now
- 21%
- of trials open to enrollment
- 16
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Toyos Clinic
Active & Recent Trials
42 total, page 1 of 1
An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
Vanda Pharmaceuticals
NCT07179055
Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK
Vance Thompson Vision
NCT07155070
The THINK Study Incidence of Neurotrophic Keratopathy)
Research Insight
NCT06482164
Low Level Light Therapy & Skin Pigmentation
University of Houston
NCT07173530
A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
Vanda Pharmaceuticals
NCT06296966
Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work
Southern College of Optometry
NCT07266948
Quality of Life in Presbyopic Patients Who Are Treated With Qlosi
Southern College of Optometry
NCT07113210
Performance of Systane PRO Versus Refresh Optive Mega-3
Scripps Poway Eyecare and Optometry
NCT06975891
Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease
Toyos Clinic
NCT06964269
A Study to Evaluate Corneal Endothelial Cell Density (ECD) in Subjects With Dry Eye Disease (DED) Administering Miebo® (Perfluorohexyloctane Ophthalmic Solution) for 12 Months.
Bausch & Lomb Incorporated
NCT06565650
Phase 2b Controlled Study of Dosing Techniques - Part B
IVIEW Therapeutics
NCT07161011
DOMPE -MT Neurotrophic Keratitis
Toyos Clinic
NCT06947850
A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease
Novartis Pharmaceuticals
NCT04391894
The RENEW Trial: A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
Aldeyra Therapeutics
NCT03879863
The TRANQUILITY 2 Trial: A Phase 3 Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease
Aldeyra Therapeutics
NCT05062330
A Study of ALTY-0501 for the Treatment of Dry Eye Administered 4 Times a Day for a 56 Day Period
Alacrity Biosciences
NCT00439400
An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Eye
Dompé Farmaceutici S.p.A
NCT03019627
Study Assessing Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients
Santen
NCT01118754
Evaluation of SYSTANE Ultra Lubricant Eye Drops
Alcon Research
NCT00702377
A Study to Evaluate Concomitant Perfluorohexyloctane Use With Contact Lens Wear
Bausch & Lomb Incorporated
NCT07054606
Safety and Efficacy Study on Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (PROTEGO-1 Study)
Dompé Farmaceutici S.p.A
NCT05133180
Evaluate the Safety and Efficacy of Calcitonin Gene-Related Peptide (CGRP) Antagonists in Patients With Dry Eye Disease and Asthenopia
Nvision Laser Eye Centers
NCT05895500
The Chronology of Lifitegrast Effect on Anterior Surface Rehabilitation (CLEAR) Study
Research Insight
NCT04669561
Treatment of Patients With Blepharitis and Facial Rosacea
Galderma R&D
NCT00560703
Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease
Cambium Bio Limited
NCT03414645
Tear Dynamics After Restasis Treatment in Dry Eye Patients
University of Miami
NCT00706940
Dailies Total 1 Sphere Contact Lenses
University of Alabama at Birmingham
NCT05239494
Oasys vs. Extreme H20 Xtra 59
Innovative Medical
NCT00477763
Evaluation of Extended Tear Film Break Up Time (TFBUT) With an Ocular Emulsion
Alcon Research
NCT01368198
Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort
University of Alabama at Birmingham
NCT03682809
Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?
University of Miami
NCT02701764
Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus
Illinois College of Optometry
NCT04418999
Effects of Cataract Extraction Surgery and Limbal Relaxing Incision on Corneal Sensation and Dry Eye
Allergan
NCT01161771
Digital Device Users Who Are Treated With Systane Hydration PF
University of Alabama at Birmingham
NCT04837807
Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms
Lifelong Vision Foundation
NCT03451396
Study of the TearCare System in Dry Eye Disease
Sight Sciences
NCT03588624
Acute Comfort of Lubricant Eye Drops FID 112903
Alcon Research
NCT00673855
Efficacy of IPL Treatment of Dry Eye and Ocular Rosacea
Mayo Clinic
NCT03194698
Tear Lipid Layer Thickness Assessments With Perfluorohexyloctane Eye Drops
Ohio State University
NCT05288582
Intense Pulse Light Treatment With Meibomian Gland Expression of the Upper Eyelids in Dry Eye Disease
Toyos Clinic
NCT03658811
Corneal Epithelial Stem Cells and Dry Eye Disease
Sloan W. Rush, MD
NCT03302273
A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion
John C Meyer, MD
NCT04022382
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 8 |
| Phase 3 | 3 |
| Phase 4 | 13 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Dry Eye Trial Landscape
42 indexed Dry Eye studies · 9 recruiting (21%).
Phase mix: 16 late (III/IV) vs 11 early (I/II).
Top sponsor: Toyos Clinic (3 trials), 9 others listed. 42 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Dry Eye?
PlainTrial tracks 42 US clinical trials for Dry Eye, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Dry Eye?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.