Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Dry Eye: full-pipeline trial registry
9 of 42 indexed Dry Eye trials are currently recruiting.
Corpus placement: #347 of 28,707 conditions by registered trial count.
42 US clinical trials · 9 currently recruiting · #347 of 28,707 conditions by registered trial count
Dry Eye: 42 US clinical trials tracked, 9 recruiting.
Dry Eye is the subject of 42 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Toyos Clinic, running 3 of these trials.
Enrollment posture brief
Registry condition dry-eye
OPEN 9 | RECR 21% | LATE 16 | EARLY 11 | RANK #347 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Cervical Adenocarcinoma (21% recruiting · 14 trials)
Dry Eye lists 9 open slots (21% of 42 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Dry Eye on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Dry Eye is recruiting below its size-band peers.
9 of 42 indexed trials (21.4%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Dry Eye trials is spread across many organizations.
Toyos Clinic accounts for 3 of 42 trials (7.1%). 29 distinct sponsors appear on at least one study for this condition label.
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Most Dry Eye trials plan to enrol fewer than 100 people.
Median target enrolment is 50 among the 42 trials that report a genuine target (sentinel values excluded). 29 of those (69%) plan for fewer than 100 participants.
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Dry Eye research is mostly interventional.
39 interventional and 3 observational studies make up this index (92.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
42 total, page 1 of 1
An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
Vanda Pharmaceuticals
NCT07179055
Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK
Vance Thompson Vision
NCT07155070
The THINK Study Incidence of Neurotrophic Keratopathy)
Research Insight
NCT06482164
Low Level Light Therapy & Skin Pigmentation
University of Houston
NCT07173530
A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye
Vanda Pharmaceuticals
NCT06296966
Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work
Southern College of Optometry
NCT07266948
Quality of Life in Presbyopic Patients Who Are Treated With Qlosi
Southern College of Optometry
NCT07113210
Performance of Systane PRO Versus Refresh Optive Mega-3
Scripps Poway Eyecare and Optometry
NCT06975891
Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease
Toyos Clinic
NCT06964269
A Study to Evaluate Corneal Endothelial Cell Density (ECD) in Subjects With Dry Eye Disease (DED) Administering Miebo® (Perfluorohexyloctane Ophthalmic Solution) for 12 Months.
Bausch & Lomb Incorporated
NCT06565650
Phase 2b Controlled Study of Dosing Techniques - Part B
IVIEW Therapeutics
NCT07161011
DOMPE -MT Neurotrophic Keratitis
Toyos Clinic
NCT06947850
A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease
Novartis Pharmaceuticals
NCT04391894
The RENEW Trial: A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
Aldeyra Therapeutics
NCT03879863
The TRANQUILITY 2 Trial: A Phase 3 Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease
Aldeyra Therapeutics
NCT05062330
A Study of ALTY-0501 for the Treatment of Dry Eye Administered 4 Times a Day for a 56 Day Period
Alacrity Biosciences
NCT00439400
An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Eye
Dompé Farmaceutici S.p.A
NCT03019627
Study Assessing Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients
Santen
NCT01118754
Evaluation of SYSTANE Ultra Lubricant Eye Drops
Alcon Research
NCT00702377
A Study to Evaluate Concomitant Perfluorohexyloctane Use With Contact Lens Wear
Bausch & Lomb Incorporated
NCT07054606
Safety and Efficacy Study on Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (PROTEGO-1 Study)
Dompé Farmaceutici S.p.A
NCT05133180
Evaluate the Safety and Efficacy of Calcitonin Gene-Related Peptide (CGRP) Antagonists in Patients With Dry Eye Disease and Asthenopia
Nvision Laser Eye Centers
NCT05895500
The Chronology of Lifitegrast Effect on Anterior Surface Rehabilitation (CLEAR) Study
Research Insight
NCT04669561
Treatment of Patients With Blepharitis and Facial Rosacea
Galderma R&D
NCT00560703
Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease
Cambium Bio Limited
NCT03414645
Tear Dynamics After Restasis Treatment in Dry Eye Patients
University of Miami
NCT00706940
Dailies Total 1 Sphere Contact Lenses
University of Alabama at Birmingham
NCT05239494
Oasys vs. Extreme H20 Xtra 59
Innovative Medical
NCT00477763
Evaluation of Extended Tear Film Break Up Time (TFBUT) With an Ocular Emulsion
Alcon Research
NCT01368198
Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort
University of Alabama at Birmingham
NCT03682809
Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?
University of Miami
NCT02701764
Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus
Illinois College of Optometry
NCT04418999
Effects of Cataract Extraction Surgery and Limbal Relaxing Incision on Corneal Sensation and Dry Eye
Allergan
NCT01161771
Digital Device Users Who Are Treated With Systane Hydration PF
University of Alabama at Birmingham
NCT04837807
Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms
Lifelong Vision Foundation
NCT03451396
Study of the TearCare System in Dry Eye Disease
Sight Sciences
NCT03588624
Acute Comfort of Lubricant Eye Drops FID 112903
Alcon Research
NCT00673855
Efficacy of IPL Treatment of Dry Eye and Ocular Rosacea
Mayo Clinic
NCT03194698
Tear Lipid Layer Thickness Assessments With Perfluorohexyloctane Eye Drops
Ohio State University
NCT05288582
Intense Pulse Light Treatment With Meibomian Gland Expression of the Upper Eyelids in Dry Eye Disease
Toyos Clinic
NCT03658811
Corneal Epithelial Stem Cells and Dry Eye Disease
Sloan W. Rush, MD
NCT03302273
A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion
John C Meyer, MD
NCT04022382
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 8 |
| Phase 3 | 3 |
| Phase 4 | 13 |
Top Sponsors
Named interventions
Most-linked intervention names on Dry Eye records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Dry Eye trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Dry Eye page
42 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 9 Dry Eye trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Toyos Clinic sponsors the most Dry Eye trials on record, review their full trial history before evaluating a specific study. See Toyos Clinic's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Dry Eye condition card totals 42 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.