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ClinicalTrials.gov 9 recruiting now official registry

Dry Eye clinical trials

9 of 42 indexed Dry Eye trials are currently recruiting.

42 US clinical trials · 9 currently recruiting

Dry Eye is the subject of 42 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Toyos Clinic, running 3 of these trials.

The research picture

Dry Eye has 42 registered US clinical trials, 9 of them open to new participants right now, about 21% of the total.

9
recruiting participants now
21%
of trials open to enrollment
16
in Phase 3–4 (later-stage)
3
top sponsor: Toyos Clinic
Phase 13Phase 28Phase 33Phase 413

Active & Recent Trials

42 total, page 1 of 1

RECRUITING Phase 2 160 participants

An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye

Vanda Pharmaceuticals

NCT07179055

RECRUITING Phase 4 60 participants

Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK

Vance Thompson Vision

NCT07155070

RECRUITING NA 60 participants

The THINK Study Incidence of Neurotrophic Keratopathy)

Research Insight

NCT06482164

RECRUITING NA 40 participants

Low Level Light Therapy & Skin Pigmentation

University of Houston

NCT07173530

RECRUITING Phase 2 40 participants

A Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye

Vanda Pharmaceuticals

NCT06296966

RECRUITING Phase 4 40 participants

Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work

Southern College of Optometry

NCT07266948

RECRUITING Phase 4 36 participants

Quality of Life in Presbyopic Patients Who Are Treated With Qlosi

Southern College of Optometry

NCT07113210

RECRUITING Phase 4 35 participants

Performance of Systane PRO Versus Refresh Optive Mega-3

Scripps Poway Eyecare and Optometry

NCT06975891

RECRUITING Phase 4 20 participants

Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease

Toyos Clinic

NCT06964269

ACTIVE NOT RECRUITING Phase 4 216 participants

A Study to Evaluate Corneal Endothelial Cell Density (ECD) in Subjects With Dry Eye Disease (DED) Administering Miebo® (Perfluorohexyloctane Ophthalmic Solution) for 12 Months.

Bausch & Lomb Incorporated

NCT06565650

ACTIVE NOT RECRUITING Phase 2 30 participants

Phase 2b Controlled Study of Dosing Techniques - Part B

IVIEW Therapeutics

NCT07161011

ACTIVE NOT RECRUITING Phase 4 10 participants

DOMPE -MT Neurotrophic Keratitis

Toyos Clinic

NCT06947850

COMPLETED Phase 2 718 participants

A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease

Novartis Pharmaceuticals

NCT04391894

COMPLETED Phase 3 422 participants

The RENEW Trial: A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease

Aldeyra Therapeutics

NCT03879863

COMPLETED Phase 3 361 participants

The TRANQUILITY 2 Trial: A Phase 3 Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease

Aldeyra Therapeutics

NCT05062330

COMPLETED Phase 2 160 participants

A Study of ALTY-0501 for the Treatment of Dry Eye Administered 4 Times a Day for a 56 Day Period

Alacrity Biosciences

NCT00439400

COMPLETED Phase 2 150 participants

An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Eye

Dompé Farmaceutici S.p.A

NCT03019627

COMPLETED Phase 1 132 participants

Study Assessing Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients

Santen

NCT01118754

COMPLETED NA 109 participants

Evaluation of SYSTANE Ultra Lubricant Eye Drops

Alcon Research

NCT00702377

COMPLETED Phase 4 104 participants

A Study to Evaluate Concomitant Perfluorohexyloctane Use With Contact Lens Wear

Bausch & Lomb Incorporated

NCT07054606

COMPLETED Phase 3 104 participants

Safety and Efficacy Study on Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (PROTEGO-1 Study)

Dompé Farmaceutici S.p.A

NCT05133180

COMPLETED 103 participants

Evaluate the Safety and Efficacy of Calcitonin Gene-Related Peptide (CGRP) Antagonists in Patients With Dry Eye Disease and Asthenopia

Nvision Laser Eye Centers

NCT05895500

COMPLETED Phase 4 100 participants

The Chronology of Lifitegrast Effect on Anterior Surface Rehabilitation (CLEAR) Study

Research Insight

NCT04669561

COMPLETED Phase 2 70 participants

Treatment of Patients With Blepharitis and Facial Rosacea

Galderma R&D

NCT00560703

COMPLETED Phase 1 64 participants

Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease

Cambium Bio Limited

NCT03414645

COMPLETED 60 participants

Tear Dynamics After Restasis Treatment in Dry Eye Patients

University of Miami

NCT00706940

COMPLETED NA 60 participants

Dailies Total 1 Sphere Contact Lenses

University of Alabama at Birmingham

NCT05239494

COMPLETED Phase 4 52 participants

Oasys vs. Extreme H20 Xtra 59

Innovative Medical

NCT00477763

COMPLETED NA 50 participants

Evaluation of Extended Tear Film Break Up Time (TFBUT) With an Ocular Emulsion

Alcon Research

NCT01368198

COMPLETED Phase 4 46 participants

Evaluation of Systane Complete for the Treatment of Contact Lens Discomfort

University of Alabama at Birmingham

NCT03682809

COMPLETED Phase 2 43 participants

Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis?

University of Miami

NCT02701764

COMPLETED Early Phase 1 36 participants

Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus

Illinois College of Optometry

NCT04418999

COMPLETED 32 participants

Effects of Cataract Extraction Surgery and Limbal Relaxing Incision on Corneal Sensation and Dry Eye

Allergan

NCT01161771

COMPLETED Phase 4 30 participants

Digital Device Users Who Are Treated With Systane Hydration PF

University of Alabama at Birmingham

NCT04837807

COMPLETED Phase 4 30 participants

Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms

Lifelong Vision Foundation

NCT03451396

COMPLETED NA 29 participants

Study of the TearCare System in Dry Eye Disease

Sight Sciences

NCT03588624

COMPLETED NA 20 participants

Acute Comfort of Lubricant Eye Drops FID 112903

Alcon Research

NCT00673855

COMPLETED NA 20 participants

Efficacy of IPL Treatment of Dry Eye and Ocular Rosacea

Mayo Clinic

NCT03194698

COMPLETED NA 20 participants

Tear Lipid Layer Thickness Assessments With Perfluorohexyloctane Eye Drops

Ohio State University

NCT05288582

COMPLETED NA 19 participants

Intense Pulse Light Treatment With Meibomian Gland Expression of the Upper Eyelids in Dry Eye Disease

Toyos Clinic

NCT03658811

COMPLETED NA 17 participants

Corneal Epithelial Stem Cells and Dry Eye Disease

Sloan W. Rush, MD

NCT03302273

COMPLETED NA 17 participants

A Study to Evaluate the Safety and Effectiveness Assessments of Restylane-Defyne for Punctual Occlusion

John C Meyer, MD

NCT04022382

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 8
Phase 3 3
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Dry Eye Trial Landscape

42 indexed Dry Eye studies · 9 recruiting (21%).

Phase mix: 16 late (III/IV) vs 11 early (I/II).

Top sponsor: Toyos Clinic (3 trials), 9 others listed. 42 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Dry Eye?

PlainTrial tracks 42 US clinical trials for Dry Eye, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Dry Eye?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.