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NCT07428447 · ClinicalTrials.gov registry record
Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease
A clinical trial of Essential Tremor and Essential Tremor, Movement Disorders, sponsored by CND Life Sciences.
- Recruiting
- Registry status
- 300
- Enrollment target
- 1
- Study location
NCT07428447 is a study of Essential Tremor and Essential Tremor, Movement Disorders that is actively recruiting participants, run by CND Life Sciences. The registered enrollment target is 300 participants, below the 395-participant average among 41 other Essential Tremor trials with a reported enrollment target (24% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07428447, a study of Essential Tremor and Essential Tremor, Movement Disorders, is actively recruiting participants, sponsored by CND Life Sciences.
- RECRUITING
- Registry status
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
Background and Rationale Essential tremor (ET) affects over 6 million Americans and approximately 5% of adults over age 60. Patients with ET have a 10-20 times higher risk of developing Parkinson's disease (PD) compared to age-matched populations, with approximately 1% converting to PD annually. Post-mortem studies reveal Lewy body pathology in some ET patients, suggesting a subset may have prodromal PD. Current diagnostic tools (DaTscan, SYNTap) are either insufficiently sensitive for early disease, too expensive, or too invasive for routine screening. The Syn-One Test offers a minimally invasive approach to detect phosphorylated α-synuclein (P-SYN) pathology in skin biopsies. Primary Objectives 1. Identify which ET patients have P-SYN pathology indicative of prodromal PD 2. Predict which patients are most likely to phenoconvert to PD
Conditions Studied
Study Locations (1)
Arizona
- CND Clinical Research Center - Scottsdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2026-02-18 |
| Est. Completion | 2029-02 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07428447
The ClinicalTrials.gov registry entry for NCT07428447 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 395-participant average among 41 other Essential Tremor trials with a reported enrollment target (24% lower). The listed sponsor is CND Life Sciences, which has 8 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Essential Tremor appearing as the primary indexed condition, and to 0 interventions.
NCT07428447 reports 1 study location spanning 1 distinct geographic area - top geographies include Arizona.
Frequently Asked Questions
What is clinical trial NCT07428447 about?
NCT07428447 is a clinical study titled "Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease". Background and Rationale Essential tremor (ET) affects over 6 million Americans and approximately 5% of adults over age 60. Patients with ET have a 10-20 times higher risk of developing Parkinson's disease (PD) compared to age-matched populations, with approximately 1% converting to PD annually. Pos...
What is the current status of trial NCT07428447?
This trial is currently recruiting. The enrollment target is 300 participants. The study started on 2026-02-18. Estimated completion is 2029-02.
What conditions does trial NCT07428447 study?
This clinical trial studies the following conditions: Essential Tremor, Essential Tremor, Movement Disorders, Essential Tremor-plus.
Who is sponsoring clinical trial NCT07428447?
This trial is sponsored by CND Life Sciences, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07428447 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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