Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06635811 · ClinicalTrials.gov registry record · NA
Circadian Adaptive DBS in Essential Tremor
A NA study of Essential Tremor, sponsored by University of Florida.
- Recruiting
- Registry status
- NA
- Development phase
- 25
- Enrollment target
- 1
- Study location
NCT06635811: Recruiting NA study of Essential Tremor, sponsored by University of Florida.
NCT06635811 is a NA study of Essential Tremor that is actively recruiting participants, run by University of Florida. The registered enrollment target is 25 participants, below the 402-participant average among 41 other Essential Tremor trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06635811, a NA study of Essential Tremor, is actively recruiting participants, sponsored by University of Florida.
- RECRUITING
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
- 1
- Study location
Study Summary
Deep brain stimulation (DBS) of the thalamus is an effective treatment for medically refractory essential tremor (ET). DBS involves delivering continuous stimulation to the brain through electrodes permanently implanted in the thalamus. Despite proven effectiveness, the long-term benefit of DBS can wane over time (habituation) and side effects, including paresthesia and dysarthria, often limit the amplitude of the stimulation, resulting in suboptimal control of tremor. In clinical practice, many groups advise patients to switch their devices off at night to avoid habituation and reduce side effects. However, manually turning off the device at night can result in uncontrolled tremor when the patient moves at night. This study aims to develop an algorithm that automatically turns off stimulation when a patient is asleep, based on circadian brain signals. Turning off stimulation could potentially improve the therapy by limiting adverse effects, increasing efficacy, reducing the risk of habituation, and prolonging battery life. This study will evaluate the feasibility, safety, and tolerability of circadian adaptive DBS.
Primary Outcome
Thalamic circadian rhythm is defined as a significant difference in day vs night brain activity. It can be used to set up adaptive DBS.
Conditions Studied
Interventions
- DEVICE Circadian Adaptive DBS
- DEVICE Conventional DBS
Study Locations (1)
Florida
- Norman Fixel Institute for Neurological Diseases - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2029-10 |
| Phase | NA |
What NCT06635811 shows while recruiting
NCT06635811 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 402-participant average among 41 other Essential Tremor trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Essential Tremor appearing as the primary indexed condition, and to 2 interventions - of which Circadian Adaptive DBS is the first listed.
NCT06635811 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT06635811 about?
NCT06635811 is a clinical study titled "Circadian Adaptive DBS in Essential Tremor". Deep brain stimulation (DBS) of the thalamus is an effective treatment for medically refractory essential tremor (ET). DBS involves delivering continuous stimulation to the brain through electrodes permanently implanted in the thalamus. Despite proven effectiveness, the long-term benefit of DBS can ...
What is the current status of trial NCT06635811?
This trial is currently recruiting. It is a NA study. The enrollment target is 25 participants. The study started on 2025-05-01. Estimated completion is 2029-10.
What conditions does trial NCT06635811 study?
This clinical trial studies the following conditions: Essential Tremor.
What interventions are being tested in trial NCT06635811?
The interventions under investigation include: Circadian Adaptive DBS (DEVICE), Conventional DBS (DEVICE).
Who is sponsoring clinical trial NCT06635811?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06635811 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Essential Tremor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06635811's enrollment target sits among peer trials
25 29th of 41 higher than 12 of 41 other Essential Tremor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Essential Tremor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Motor Network Physiology
RECRUITING · NA
-
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
RECRUITING · NA
-
3-D Tractography FUS Ablation for Essential Tremor
RECRUITING · NA
-
Directional Versus Nondirectional DBS for ET
RECRUITING · NA
-
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
RECRUITING · NA
-
Algorithms for Programming DBS Systems for ET
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01166854 · 25 participants
Characterization of Familial Myopathy and Paget Disease of Bone
- NCT01913106 · 25 participants · Phase 1
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
- NCT02138669 · 25 participants · NA
Intacs Prescription Inserts for Keratoconus Patients
- NCT02174549 · 25 participants · Phase 1
Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI