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NCT07049003 · ClinicalTrials.gov registry record · Phase 1
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
A Phase 1 study of Essential Tremor and Tremor, sponsored by The Cleveland Clinic.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT07049003: Recruiting Phase 1 study of Essential Tremor and Tremor, sponsored by The Cleveland Clinic.
NCT07049003 is a Phase 1 study of Essential Tremor and Tremor that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 12 participants, below the 402-participant average among 41 other Essential Tremor trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07049003, a Phase 1 study of Essential Tremor and Tremor, is actively recruiting participants, sponsored by The Cleveland Clinic.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System. The population will consist of patients that have either failed a prior intervention (Vim DBS or HIFU thalamotomy) or determined to not be suitable candidates for Vim DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor. Those patients with a previous intervention, must have a prior diagnosis of ET, cerebellar outflow tremor, or MS-related tremor. Subjects without a previous intervention must have a diagnosis of cerebellar outflow tremor or MS-related tremor.
Primary Outcome
The accumulation of adverse events across all subjects
Conditions Studied
Interventions
- DEVICE Deep Brain Stimulation
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2025-05-19 |
| Est. Completion | 2028-12-31 |
| Phase | Phase 1 |
What NCT07049003 shows while recruiting
NCT07049003 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 402-participant average among 41 other Essential Tremor trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Essential Tremor appearing as the primary indexed condition, and to 1 intervention - of which Deep Brain Stimulation is the first listed.
NCT07049003 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT07049003 about?
NCT07049003 is a clinical study titled "Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor". This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System. The population will consist of patients that have either failed a prior intervention (Vim...
What is the current status of trial NCT07049003?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2025-05-19. Estimated completion is 2028-12-31.
What conditions does trial NCT07049003 study?
This clinical trial studies the following conditions: Essential Tremor, Tremor.
What interventions are being tested in trial NCT07049003?
The interventions under investigation include: Deep Brain Stimulation (DEVICE).
Who is sponsoring clinical trial NCT07049003?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07049003 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07049003's enrollment target sits among peer trials
12 39th of 41 higher than 1 of 41 other Essential Tremor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Essential Tremor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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