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NCT07455760 · ClinicalTrials.gov registry record · NA

Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

A NA study of Essential Tremor and Parkinsons Disease (PD), sponsored by Boston University Charles River Campus.

Recruiting
Registry status
NA
Development phase
80
Enrollment target
2
Study locations

NCT07455760: Recruiting NA study of Essential Tremor and Parkinsons Disease (PD), sponsored by Boston University Charles River Campus.

NCT07455760 is a NA study of Essential Tremor and Parkinsons Disease (PD) that is actively recruiting participants, run by Boston University Charles River Campus. The registered enrollment target is 80 participants, below the 401-participant average among 41 other Essential Tremor trials with a reported enrollment target (80% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT07455760, a NA study of Essential Tremor and Parkinsons Disease (PD), is actively recruiting participants, sponsored by Boston University Charles River Campus.

RECRUITING
Registry status
NA
Development phase
80 participants
Enrollment target
2
Study locations

Study Summary

This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech sequences. Participants will include two groups: 1. individuals with Parkinson's disease who have deep brain stimulation (DBS) devices targeting the STN and 2. individuals with essential tremor who have DBS devices targeting the VIM. Participants will complete speech tasks involving the learning and repetition of novel sound sequences. During some parts of the study, DBS stimulation will be temporarily turned on or off in a controlled research setting. This will allow researchers to examine how stimulation affects both the learning of new speech sequences and the production of previously learned sequences. All STN participants and most VIM participants will also be equipped with a cutting-edge DBS system, the Percept PC, which will enable the recording of deep brain activity during the tasks. The results of this study will improve our understanding of how different brain circuits support speech learning and production. In particular, this study will help to differentiate the roles of the STN and VIM in learning the ordering of speech sounds within a syllable from learning of speech sequences containing multiple syllables. This knowledge may help guide future approaches to optimizing DBS settings to improve both movement and speech outcomes in individuals with neurological disorders, as well as provide greater general insight into how these brain structures contribute to speech production and learning.

Primary Outcome

Investigators will evaluate recordings of speech productions to identify errors. This will be used to compare sequence accuracy before and after practice of novel sequences with DBS in the ON and OFF states.

Conditions Studied

Essential Tremor Parkinsons Disease (PD)

Interventions

  • BEHAVIORAL Phoneme sequence learning
  • OTHER Cessation and re-enabling of stimulation of the STN
  • OTHER Cessation and re-enabling of stimulation of the VIM thalamic nucleus
  • BEHAVIORAL Multisyllabic sequence learning

Study Locations (2)

Massachusetts

  • Boston University - Boston
  • Massachusetts General Hospital - Boston

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2026-02-18
Est. Completion 2030-08
Phase NA
Boston University Charles River Campus

104 total trials

What NCT07455760 shows while recruiting

NCT07455760 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 401-participant average among 41 other Essential Tremor trials with a reported enrollment target (80% lower).

The record links to 2 conditions, with Essential Tremor appearing as the primary indexed condition, and to 4 interventions - of which Phoneme sequence learning is the first listed.

NCT07455760 reports a single indexed study location in Massachusetts.

Frequently Asked Questions

What is clinical trial NCT07455760 about?

NCT07455760 is a clinical study titled "Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients". This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech sequences. Participants will include two groups: 1. individuals with Parkinson...

What is the current status of trial NCT07455760?

This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2026-02-18. Estimated completion is 2030-08.

What conditions does trial NCT07455760 study?

This clinical trial studies the following conditions: Essential Tremor, Parkinsons Disease (PD).

What interventions are being tested in trial NCT07455760?

The interventions under investigation include: Phoneme sequence learning (BEHAVIORAL), Cessation and re-enabling of stimulation of the STN (OTHER), Cessation and re-enabling of stimulation of the VIM thalamic nucleus (OTHER), Multisyllabic sequence learning (BEHAVIORAL).

Who is sponsoring clinical trial NCT07455760?

This trial is sponsored by Boston University Charles River Campus, which has 104 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07455760 being conducted?

This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Essential Tremor

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT07455760's enrollment target sits among peer trials

80 16th of 41 higher than 24 of 41 other Essential Tremor trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Essential Tremor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT07455760

Source: ClinicalTrials.gov NCT07455760, the US trial registry maintained by the National Library of Medicine. NCT07455760 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.