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ClinicalTrials.gov 4 recruiting now later-stage tilt small index

ACL: later-stage trial registry

4 of 7 indexed ACL trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #2,497 of 28,707 conditions by registered trial count.

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7 US clinical trials · 4 currently recruiting · #2,497 of 28,707 conditions by registered trial count

ACL: 7 US clinical trials tracked, 4 recruiting.

ACL is the subject of 7 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 0 in Phase 1-2 (earlier-stage). The most active sponsor is Hospital for Special Surgery, New York, running 2 of these trials.

Enrollment posture brief

Registry condition acl

OPEN 4 | RECR 57% | LATE 1 | EARLY 0 | RANK #2497 | SPON 2

Volume-matched condition peers

Nearest open-share peer: Adverse Childhood Experiences (57% recruiting · 14 trials)

ACL Tear71.4%ACL (this)57%Acute Myelogenous Leukemia42.9%Acne Scars28.6%Adenoma28.6%
Open-enrollment share among volume-matched conditions near ACL

ACL lists 4 open slots (57% of 7 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for ACL on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. ACL is recruiting above its size-band peers.

    4 of 7 indexed trials (57.1%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates ACL research.

    Hospital for Special Surgery, New York accounts for 2 of 7 trials (28.6%). 5 distinct sponsors appear on at least one study for this condition label.

  3. Typical ACL enrolment sits around 40 participants.

    Median target enrolment is 40 among the 7 trials that report a genuine target (sentinel values excluded). 4 of those (57.1%) plan for fewer than 100 participants.

  4. ACL research is mostly interventional.

    7 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 41

Phase Distribution

PhaseTrial count
Phase 4 1

Top Sponsors

Hospital for Special Surgery, New York 2 trials
University of Michigan 2 trials
Columbia University 1 trials
University of Pittsburgh 1 trials
University of Wisconsin, Madison 1 trials

Named interventions

Most-linked intervention names on ACL records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Acupuncture + Standard of Care Other
1 trials
ACL Recon. extra-articular-tenodesis Procedure
1 trials
Genicular Nerve Block with bupivacaine and preservative free dexamethasone Drug
1 trials
Standard ice packs Device
1 trials
Cryocompression (Game Ready, Bregs) device Device
1 trials
VibraCool mechanical stimulation and neuromodulatory therapeutic device Device
1 trials
Healthy Minds Program (HMP) App Behavioral
1 trials
ACL Reconstruction Procedure
1 trials

US sites by state

Facility locations filed on ACL trials. A trial with sites in several states counts in each.

New York 3 trials
Michigan 2 trials
Wisconsin 1 trials
Pennsylvania 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Related

Read our methodology - how this data is sourced, computed, and verified.

What to do with this ACL page

7 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This ACL condition card totals 7 registered trials; most-linked intervention Acupuncture + Standard of Care; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.