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ClinicalTrials.gov 12 recruiting now official registry

Graft-Versus-Host Disease clinical trials

12 of 42 indexed Graft-Versus-Host Disease trials are currently recruiting.

42 US clinical trials · 12 currently recruiting

Graft-Versus-Host Disease is the subject of 42 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 33 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 5 of these trials.

The research picture

Graft-Versus-Host Disease has 42 registered US clinical trials, 12 of them open to new participants right now, about 29% of the total.

12
recruiting participants now
29%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
5
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 116Phase 217Phase 31Phase 41

Active & Recent Trials

42 total, page 1 of 1

RECRUITING 500 participants

Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives

National Heart, Lung, and Blood Institute (NHLBI)

NCT00001529

RECRUITING 500 participants

Chronic Graft-versus-Host Disease in the Oral Cavity of Patients Following Allogeneic Hematopoietic Stem Cell Transplant and Including Healthy Controls

National Institute of Dental and Craniofacial Research (NIDCR)

NCT03602599

RECRUITING 375 participants

Parametric Response Mapping (PRM) for the Detection of Chronic Lung Injury in Hematopoietic Cell Transplant Recipients

University of Michigan Rogel Cancer Center

NCT05866302

RECRUITING NA 350 participants

Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

Massachusetts General Hospital

NCT06910969

RECRUITING NA 90 participants

A Feasibility Study Using CLINIMACS® for Alpha/Beta T-Cell Depletion in Stem Cell Transplant

Christopher Dvorak

NCT04337515

RECRUITING Phase 2 46 participants

A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant

Memorial Sloan Kettering Cancer Center

NCT07006506

RECRUITING Phase 2 44 participants

A Study of Photobiomodulation (PBM) Therapy in People With Oral Graft-Versus-Host Disease (GVHD) After Stem Cell Transplant

Memorial Sloan Kettering Cancer Center

NCT05675930

RECRUITING Phase 2 44 participants

Ruxolitinib Maintenance Post-Hematopoietic Stem Cell Transplant T-Cell Lymphoma

Jonathan Brammer

NCT07356245

RECRUITING Phase 1 41 participants

Ruxolitinib With and Without CTLA-4 Ig Abatacept for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Washington University School of Medicine

NCT06008808

RECRUITING Phase 1 36 participants

Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia

University of Wisconsin, Madison

NCT06392711

RECRUITING Phase 2 35 participants

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

City of Hope Medical Center

NCT06815003

RECRUITING Phase 1 18 participants

PTCY Plus uhCG/EGF for Graft Versus Host Disease Prophylaxis

Henry Ford Health System

NCT04886726

ACTIVE NOT RECRUITING Phase 1 105 participants

Optimizing PTCy Dose and Timing

National Cancer Institute (NCI)

NCT03983850

ACTIVE NOT RECRUITING Phase 1 74 participants

Post-Transplant Cyclophosphamide, Bortezomib and Abatacept for the Prevention of Graft-versus-Host-Disease (GvHD)

Northwell Health

NCT05289167

ACTIVE NOT RECRUITING Phase 2 56 participants

De-escalated Cyclophosphamide (PTCy) and Ruxolitinib for Graft-versus-Host Disease (GVHD) Prophylaxis

Medical College of Wisconsin

NCT05622318

ACTIVE NOT RECRUITING Phase 1 35 participants

Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

Roswell Park Cancer Institute

NCT03192397

ACTIVE NOT RECRUITING Phase 2 30 participants

Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant

Emory University

NCT03924401

COMPLETED Phase 2 90 participants

Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Other Hematologic or Metabolic Diseases

Roswell Park Cancer Institute

NCT00003662

COMPLETED Phase 1 64 participants

Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease

Cambium Bio Limited

NCT03414645

COMPLETED Phase 1 53 participants

Phase 1/2 Study of Carfilzomib for the Prevention of Relapse and GVHD in Allo-HCT for Hematologic Malignancies

University of Michigan Rogel Cancer Center

NCT02145403

COMPLETED Phase 2 53 participants

Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT00410657

COMPLETED Phase 2 49 participants

RGI-2001 for the Prevention of Acute Graft-vs-Host Disease in Subjects Following Allogeneic Hematopoietic Stem Cell Transplantation

Regimmune Corporation

NCT04014790

COMPLETED Phase 4 45 participants

Bone Marrow Transplantation in Treating Patients With Hematologic Cancer

University of Maryland, Baltimore

NCT00003398

COMPLETED Phase 2 39 participants

Pentostatin in Treating Patients With Refractory Chronic Graft-Versus-Host Disease

Alliance for Clinical Trials in Oncology

NCT00074035

COMPLETED Phase 1 38 participants

Ex-vivo Expanded Donor Regulatory T Cells for Prevention of Acute Graft-Versus-Host Disease

H. Lee Moffitt Cancer Center and Research Institute

NCT01795573

COMPLETED 38 participants

Comparison of Gut Microbiota, Inflammation and Symptoms Following Allogeneic HSCT

University of Florida

NCT02398708

COMPLETED Phase 1 38 participants

Clofarabine, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk and/or Advanced Hematologic Cancer or Other Disease

Memorial Sloan Kettering Cancer Center

NCT00423514

COMPLETED Phase 2 34 participants

Campath-1H + FK506 and Methylprednisolone for GVHD

Case Comprehensive Cancer Center

NCT00109993

COMPLETED Phase 1 32 participants

Adoptive Immunotherapy With Activated Marrow Infiltrating Lymphocytes and Cyclophosphamide Graft-Versus-Host Disease Prophylaxis in Patients With Relapse of Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02342613

COMPLETED Phase 2 32 participants

Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer

City of Hope Medical Center

NCT00589563

COMPLETED Phase 2 30 participants

Sirolimus With Tacrolimus for Graft-vs-Host Disease Prophylaxis After Un-Related Stem Cell Transplantation

Dana-Farber Cancer Institute

NCT00144677

COMPLETED Phase 2 30 participants

A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD

John Levine

NCT03459040

COMPLETED Phase 1 26 participants

Baricitinib for the Prophylaxis of Graft-Versus-Host Disease After Peripheral Blood Hematopoietic Cell Transplantation

Washington University School of Medicine

NCT04131738

COMPLETED Phase 1 24 participants

Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease

Monica Bhatia

NCT02867800

COMPLETED Phase 2 16 participants

Allogeneic Transplantation From Related Haploidentical Donors

Stanford University

NCT00185692

COMPLETED 13 participants

Feasibility Study of Collecting Multicenter Chronic GVHD Data

M.D. Anderson Cancer Center

NCT00506233

COMPLETED Phase 1 10 participants

Study of MEDI 507 in the Treatment of Pediatric Patients

MedImmune

NCT00813618

COMPLETED Phase 1 5 participants

Bone Marrow Transplantation With Specially Treated Bone Marrow in Treating Patients With Hematologic Cancer That Have Not Responded to Previous Therapy

Dana-Farber Cancer Institute

NCT00005988

COMPLETED Phase 2 3 participants

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Roswell Park Cancer Institute

NCT00003661

COMPLETED Phase 2

Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Advanced Hematologic Cancer

Memorial Sloan Kettering Cancer Center

NCT00014469

COMPLETED Phase 3

Beclomethasone Plus Prednisone in Treating Patients With Graft-Versus-Host Disease

Memorial Sloan Kettering Cancer Center

NCT00043147

COMPLETED Phase 1

Bone Marrow and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Northwestern University

NCT00004232

Phase Distribution

PhaseTrial count
Phase 1 16
Phase 2 17
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Graft-Versus-Host Disease Trial Landscape

42 indexed Graft-Versus-Host Disease studies · 12 recruiting (29%).

Phase mix: 2 late (III/IV) vs 33 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (5 trials), 9 others listed. 42 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Graft-Versus-Host Disease?

PlainTrial tracks 42 US clinical trials for Graft-Versus-Host Disease, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Graft-Versus-Host Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.