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NCT06899022 · ClinicalTrials.gov registry record · NA
Attention and Eye Movement in Parkinson's Disease
A NA study of Essential Tremor and Parkinson's Disease (PD), sponsored by University of Nebraska.
- Recruiting
- Registry status
- NA
- Development phase
- 138
- Enrollment target
- 1
- Study location
NCT06899022: Recruiting NA study of Essential Tremor and Parkinson's Disease (PD), sponsored by University of Nebraska.
NCT06899022 is a NA study of Essential Tremor and Parkinson's Disease (PD) that is actively recruiting participants, run by University of Nebraska. The registered enrollment target is 138 participants, below the 399-participant average among 41 other Essential Tremor trials with a reported enrollment target (65% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06899022, a NA study of Essential Tremor and Parkinson's Disease (PD), is actively recruiting participants, sponsored by University of Nebraska.
- RECRUITING
- Registry status
- NA
- Development phase
- 138 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and essential tremor (ET). The main questions it aims to answer are: * Does impaired control of attention and eye movement in PD alter how social cues are perceived and interpreted? * Does therapeutic DBS improve or worsen attentional and perceptual deficits for social cues in PD and ET? * Can DBS be optimized to restore normal attentional control in PD while remaining an effective therapy for other aspects of the disorder. * What do parts of the brain targeted by DBS contribute to the control of attention? Using an eye tracking camera, investigators will study how participants with PD and ET look at and perceive facial expressions of emotion before and after starting DBS therapy, in comparison to a group of healthy participants without ET, PD or DBS. Participants with PD and ET will see and rate morphed facial expressions on a computer screen in three conditions: * Before starting DBS therapy (over approximately 1 hour). * In the operating room, during the standard procedure to implant DBS electrodes, while the participant is awake (for no more than 15 minutes). * After starting DBS therapy, with brief experimental changes of DBS stimulation level and frequency (over approximately 1 hour).
Primary Outcome
Participants will rate facial expression along a continuous scale using a computerized slider, following the affective bias task (ABT) of Bijanki et al. (2014). The scale is anchored with three descriptors, "Very Sad" at slider value 0 (left), "Neutral", at position 0.5 (middle), and "Very Happy" at 1.0 (right). Responses are compared between two time points: (1) at the initial pre-surgical testing session and post DBS implantation and (2) at the post-implantation session following clinical opti
Conditions Studied
Interventions
- OTHER Normal therapeutic DBS
- OTHER Reduced current DBS
- OTHER Reduced frequency DBS
Study Locations (1)
Nebraska
- University of Nebraska Medical Center - Omaha
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 138 participants |
| Start Date | 2025-09-22 |
| Est. Completion | 2028-08 |
| Phase | NA |
What NCT06899022 shows while recruiting
NCT06899022 is an interventional study that assigns participants to a tested intervention. The registered 138 participants enrollment target is mid-sized for trials with a published cap, below the 399-participant average among 41 other Essential Tremor trials with a reported enrollment target (65% lower).
The record links to 2 conditions, with Essential Tremor appearing as the primary indexed condition, and to 3 interventions - of which Normal therapeutic DBS is the first listed.
NCT06899022 reports a single indexed study location in Nebraska.
Frequently Asked Questions
What is clinical trial NCT06899022 about?
NCT06899022 is a clinical study titled "Attention and Eye Movement in Parkinson's Disease". The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and essential tremor (ET). The main questions it aims to answer are: * Does impaired contro...
What is the current status of trial NCT06899022?
This trial is currently recruiting. It is a NA study. The enrollment target is 138 participants. The study started on 2025-09-22. Estimated completion is 2028-08.
What conditions does trial NCT06899022 study?
This clinical trial studies the following conditions: Essential Tremor, Parkinson's Disease (PD).
What interventions are being tested in trial NCT06899022?
The interventions under investigation include: Normal therapeutic DBS (OTHER), Reduced current DBS (OTHER), Reduced frequency DBS (OTHER).
Who is sponsoring clinical trial NCT06899022?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06899022 being conducted?
This trial has 1 study location across Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06899022's enrollment target sits among peer trials
138 13th of 41 higher than 29 of 41 other Essential Tremor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Essential Tremor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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