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NCT06293638 · ClinicalTrials.gov registry record

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

A clinical trial of Essential Tremor, sponsored by The Cleveland Clinic.

Recruiting
Registry status
55
Enrollment target
1
Study location

NCT06293638 is a study of Essential Tremor that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 55 participants, below the 401-participant average among 41 other Essential Tremor trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06293638, a study of Essential Tremor, is actively recruiting participants, sponsored by The Cleveland Clinic.

RECRUITING
Registry status
55 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor. Participants will either 1) have electroencephalography (EEG) scalp electrodes placed, or 2) remain seated with their head inside of a magnetoencephalography (MEG) recording system, as resting-state and task-related data are acquired. Spontaneous electrophysiological activity will be recorded in both the eyes open and eyes closed conditions with the participant seated comfortably. These recordings will be repeated in the DBS OFF and DBS ON states, with the ON state involving specific settings identified as optimal, sub-optimal, or ineffective at achieving tremor control. They will also be repeated following the optional administration non-DBS tremor mitigation techniques, which may include one or more of the following: 1) cooling the limb, 2) oral administration of alprazolam, 3) oral consumption of ethanol (alcohol), or 4) peripheral nerve stimulation.

Conditions Studied

Essential Tremor

Interventions

  • DRUG Alprazolam
  • DRUG Alcohol
  • DEVICE Cold Therapy
  • PROCEDURE Peripheral Nerve Stimulation

Study Locations (1)

Ohio

  • Cleveland Clinic - Cleveland

Trial Details

FieldValue
Enrollment Target 55 participants
Start Date 2024-03-25
Est. Completion 2026-12-31

Sponsor

The Cleveland Clinic

688 total trials

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What the Registry Record Tells You About NCT06293638

The ClinicalTrials.gov registry entry for NCT06293638 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 55 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 401-participant average among 41 other Essential Tremor trials with a reported enrollment target (86% lower). The listed sponsor is The Cleveland Clinic, which has 688 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Essential Tremor appearing as the primary indexed condition, and to 4 interventions - of which Alprazolam is the first listed.

NCT06293638 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT06293638 about?

NCT06293638 is a clinical study titled "Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor". The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor. Participants will either 1) have electroencephalography (EEG) scalp electrodes placed, or 2) remain seate...

What is the current status of trial NCT06293638?

This trial is currently recruiting. The enrollment target is 55 participants. The study started on 2024-03-25. Estimated completion is 2026-12-31.

What conditions does trial NCT06293638 study?

This clinical trial studies the following conditions: Essential Tremor.

What interventions are being tested in trial NCT06293638?

The interventions under investigation include: Alprazolam (DRUG), Alcohol (DRUG), Cold Therapy (DEVICE), Peripheral Nerve Stimulation (PROCEDURE).

Who is sponsoring clinical trial NCT06293638?

This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06293638 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.