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NCT06293638 · ClinicalTrials.gov registry record
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
A clinical trial of Essential Tremor, sponsored by The Cleveland Clinic.
- Recruiting
- Registry status
- 55
- Enrollment target
- 1
- Study location
NCT06293638: Recruiting study of Essential Tremor, sponsored by The Cleveland Clinic.
NCT06293638 is a study of Essential Tremor that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 55 participants, below the 401-participant average among 41 other Essential Tremor trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06293638, a study of Essential Tremor, is actively recruiting participants, sponsored by The Cleveland Clinic.
- RECRUITING
- Registry status
- 55 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor. Participants will either 1) have electroencephalography (EEG) scalp electrodes placed, or 2) remain seated with their head inside of a magnetoencephalography (MEG) recording system, as resting-state and task-related data are acquired. Spontaneous electrophysiological activity will be recorded in both the eyes open and eyes closed conditions with the participant seated comfortably. These recordings will be repeated in the DBS OFF and DBS ON states, with the ON state involving specific settings identified as optimal, sub-optimal, or ineffective at achieving tremor control. They will also be repeated following the optional administration non-DBS tremor mitigation techniques, which may include one or more of the following: 1) cooling the limb, 2) oral administration of alprazolam, 3) oral consumption of ethanol (alcohol), or 4) peripheral nerve stimulation.
Primary Outcome
Coherence, a unitless measure of correlation between signals, calculated across the cerebellothalmocorticomuscular (CTCM) circuit, will be computed from neurophysiological recordings including electroencephalography (EEG), electromyography (EMG), magnetoencephalography (MEG), and/or local field potential (LFP), using data collected at rest, during tremor-eliciting tasks, with DBS OFF, with DBS ON (when available), and when using non-DBS tremor interventions (limb cooling and/or peripheral nerve
Conditions Studied
Interventions
- DRUG Alprazolam
- DRUG Alcohol
- DEVICE Cold Therapy
- PROCEDURE Peripheral Nerve Stimulation
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 55 participants |
| Start Date | 2024-03-25 |
| Est. Completion | 2026-12-31 |
What NCT06293638 shows while recruiting
NCT06293638 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 55 participants, a relatively small participant target, below the 401-participant average among 41 other Essential Tremor trials with a reported enrollment target (86% lower).
The record links to 1 condition, with Essential Tremor appearing as the primary indexed condition, and to 4 interventions - of which Alprazolam is the first listed.
NCT06293638 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06293638 about?
NCT06293638 is a clinical study titled "Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor". The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor. Participants will either 1) have electroencephalography (EEG) scalp electrodes placed, or 2) remain seate...
What is the current status of trial NCT06293638?
This trial is currently recruiting. The enrollment target is 55 participants. The study started on 2024-03-25. Estimated completion is 2026-12-31.
What conditions does trial NCT06293638 study?
This clinical trial studies the following conditions: Essential Tremor.
What interventions are being tested in trial NCT06293638?
The interventions under investigation include: Alprazolam (DRUG), Alcohol (DRUG), Cold Therapy (DEVICE), Peripheral Nerve Stimulation (PROCEDURE).
Who is sponsoring clinical trial NCT06293638?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06293638 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06293638's enrollment target sits among peer trials
55 24th of 41 higher than 18 of 41 other Essential Tremor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Essential Tremor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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