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NCT04957095 · ClinicalTrials.gov registry record · NA
Motor Network Physiology
A NA study of Parkinson Disease and Essential Tremor, sponsored by University of Texas Southwestern Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT04957095: Recruiting NA study of Parkinson Disease and Essential Tremor, sponsored by University of Texas Southwestern Medical Center.
NCT04957095 is a NA study of Parkinson Disease and Essential Tremor that is actively recruiting participants, run by University of Texas Southwestern Medical Center. The registered enrollment target is 120 participants, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04957095, a NA study of Parkinson Disease and Essential Tremor, is actively recruiting participants, sponsored by University of Texas Southwestern Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The brain networks controlling movement are complex, involving multiple areas of the brain. Some neurological disorders, like Parkinson's disease (PD) and essential tremor (ET), cause abnormalities in these brain networks. Deep brain stimulation is a treatment that is used to treat these types of neurological diseases and is thought to help patients by modulating brain networks responsible for movement. Levodopa medication is also used to modulate this brain networks in patients with PD. The overall objective is to develop a unified theory of basal ganglia thalamocortical (BGTC) circuit dynamics that accounts for disease symptomatology, movement, and their inter-relationship. The underlying hypothesis, is that the rigidity and bradykinesia of PD are fundamentally related to excessive functional coupling across nodes in the BGTC motor circuit impeding effective information flow. In this research, the investigator will take advantage of the unique opportunity provided by awake deep brain stimulation surgery to learn more about how the brain functions in a diseased state and how deep brain stimulation changes these networks to make movement more normal. The investigator will simultaneously assess cortical and subcortical electrophysiology in relation to clinical symptoms and behavioral measures and in response to deep brain stimulation, cortical stimulation, and pharmacologic therapy in patients undergoing Deep Brain Stimulation (DBS) implantation surgery.
Primary Outcome
Cortical ECoG and subcortical LFP recordings will occur during DBS implantation surgery during the behavioral assessments and/or Inbrija administration.
Conditions Studied
Interventions
- DRUG Apomorphine Injectable Solution
- OTHER Subcortical Stimulation
Study Locations (1)
Texas
- UT Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2022-02-18 |
| Est. Completion | 2028-12-01 |
| Phase | NA |
What NCT04957095 shows while recruiting
NCT04957095 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Parkinson Disease appearing as the primary indexed condition, and to 2 interventions - of which Apomorphine Injectable Solution is the first listed.
NCT04957095 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04957095 about?
NCT04957095 is a clinical study titled "Motor Network Physiology". The brain networks controlling movement are complex, involving multiple areas of the brain. Some neurological disorders, like Parkinson's disease (PD) and essential tremor (ET), cause abnormalities in these brain networks. Deep brain stimulation is a treatment that is used to treat these types of ne...
What is the current status of trial NCT04957095?
This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2022-02-18. Estimated completion is 2028-12-01.
What conditions does trial NCT04957095 study?
This clinical trial studies the following conditions: Parkinson Disease, Essential Tremor.
What interventions are being tested in trial NCT04957095?
The interventions under investigation include: Apomorphine Injectable Solution (DRUG), Subcortical Stimulation (OTHER).
Who is sponsoring clinical trial NCT04957095?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04957095 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04957095's enrollment target sits among peer trials
120 70th of 297 higher than 219 of 297 other Parkinson Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Parkinson Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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