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NCT04502550 · ClinicalTrials.gov registry record
Brain Networks and Consciousness
A clinical trial of Parkinson Disease and Anesthesia, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- 63
- Enrollment target
- 1
- Study location
NCT04502550 is a study of Parkinson Disease and Anesthesia that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 63 participants, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04502550, a study of Parkinson Disease and Anesthesia, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- 63 participants
- Enrollment target
- 1
- Study location
Study Summary
General anesthesia (GA) is a medically induced state of unresponsiveness and unconsciousness, which millions of people experience every year. Despite its ubiquity, a clear and consistent picture of the brain circuits mediating consciousness and responsiveness has not emerged. Studies to date are limited by lack of direct recordings in human brain during medically induced anesthesia. Our overall hypothesis is that the current model of consciousness, originally proposed to model disorders and recovery of consciousness after brain injury, can be generalized to understand mechanisms of consciousness more broadly. This will be studied through three specific aims. The first is to evaluate the difference in anesthesia sensitivity in patients with and without underlying basal ganglia pathology. Second is to correlate changes in brain circuitry with induction and emergence from anesthesia. The third aim is to evaluate the effects of targeted deep brain stimulation on anesthesia induced loss and recovery of consciousness. This study focuses on experimentally studying these related brain circuits by taking advantage of pathological differences in movement disorder patient populations undergoing deep brain stimulation (DBS) surgery. DBS is a neurosurgical procedure that is used as treatment for movement disorders, such as Parkinson's disease and essential tremor, and provides a mechanism to acquire brain activity recordings in subcortical structures. This study will provide important insight by using human data to shed light on the generalizability of the current model of consciousness. The subject's surgery for DBS will be prolonged by up to 40 minutes in order to record the participant's brain activity and their responses to verbal and auditory stimuli.
Conditions Studied
Interventions
- DRUG Propofol
Study Locations (1)
Texas
- Nader Pouratian - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 63 participants |
| Start Date | 2020-10-15 |
| Est. Completion | 2024-11-14 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04502550
The ClinicalTrials.gov registry entry for NCT04502550 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 63 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (99% lower). The listed sponsor is University of Texas Southwestern Medical Center, which has 837 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Parkinson Disease appearing as the primary indexed condition, and to 1 intervention - of which Propofol is the first listed.
NCT04502550 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT04502550 about?
NCT04502550 is a clinical study titled "Brain Networks and Consciousness". General anesthesia (GA) is a medically induced state of unresponsiveness and unconsciousness, which millions of people experience every year. Despite its ubiquity, a clear and consistent picture of the brain circuits mediating consciousness and responsiveness has not emerged. Studies to date are lim...
What is the current status of trial NCT04502550?
This trial is currently completed. The enrollment target is 63 participants. The study started on 2020-10-15. Estimated completion is 2024-11-14.
What conditions does trial NCT04502550 study?
This clinical trial studies the following conditions: Parkinson Disease, Anesthesia, Essential Tremor, Loss of Consciousness.
What interventions are being tested in trial NCT04502550?
The interventions under investigation include: Propofol (DRUG).
Who is sponsoring clinical trial NCT04502550?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04502550 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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