National Institute of Neurological Disorders and Stroke (NINDS)

339 total trials 210 currently recruiting 121 completed

Trial Pipeline

RECRUITING

Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

NCT06615973

RECRUITING

Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques

NCT07137442

RECRUITING

Predicting Future Errors During Skill Performance

NCT06707207

RECRUITING NA

DDAVP for Pituitary Adenoma

NCT04569591

RECRUITING

A Prospective Natural History and Outcome Measure Validation Study of Congenital Myasthenic Syndromes

NCT06630650

RECRUITING Early Phase 1

Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort

NCT06472622

RECRUITING

Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection

NCT06577467

RECRUITING Phase 1

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

NCT02531880

RECRUITING

Data Collection of Standard Care of Patients in the EMG Section

NCT05041387

RECRUITING

Ultra-Low Field (ULF) Point-of-Care (POC) MRI System for Brain Morphology and Pathology

NCT06203626

RECRUITING Phase 1

Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy

NCT05849467

RECRUITING

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

NCT05375812

RECRUITING

Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects

NCT05604534

RECRUITING

Natural History Protocol for Movement Disorders

NCT05413291

RECRUITING

Investigational Use of Neuromuscular Ultrasound

NCT05237973

RECRUITING

Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health

NCT04573062

RECRUITING

Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)

NCT04944940

RECRUITING Phase 1

Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

NCT04799288

RECRUITING

The Beneficial Effects of Naps on Motor Learning

NCT04312126

RECRUITING

Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing

NCT04394871

RECRUITING NA

Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery

NCT03678389

RECRUITING

Influence of Brain Oscillation-Dependent TMS on Motor Function

NCT03288220

RECRUITING

Investigating Epilepsy: Screening and Evaluation

NCT03478852

RECRUITING

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

NCT03225144

RECRUITING Phase 2

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

NCT02784210

RECRUITING

Pathological Basis of MRI Signal Changes in Multiple Sclerosis

NCT02659956

RECRUITING

Tumor Related Epilepsy

NCT02639325

RECRUITING

Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

NCT02629107

RECRUITING

Inflammatory and Infectious Diseases of the Nervous System

NCT02435810

RECRUITING NA

Deep Brain Stimulation Therapy in Movement Disorders

NCT02119611

RECRUITING

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

NCT02107989

RECRUITING

Thinking and Memory Problems in People With HIV

NCT01875588

RECRUITING NA

Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers

NCT01900132

RECRUITING

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

NCT01730131

RECRUITING

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

NCT01568658

RECRUITING NA

Deep Brain Stimulation Surgery for Movement Disorders

NCT01581580

RECRUITING

Surgery as a Treatment for Medically Intractable Epilepsy

NCT01273129

RECRUITING

Natural History Study of Patients With Neurofibromatosis Type 2

NCT00598351

RECRUITING

Evaluation and Treatment of Neurosurgical Disorders

NCT00060541

RECRUITING

Phenotype/Genotype Correlations in Movement Disorders

NCT00018889

RECRUITING

Natural History of Stroke: Cause and Development

NCT00009243

RECRUITING

Study of New Magnetic Resonance Imaging Methods of the Brain

NCT00004577

RECRUITING

Study of Inherited Neurological Disorders

NCT00004568

RECRUITING

Evaluation of Patients With HAM/TSP

NCT00001778

RECRUITING

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

NCT00001248

RECRUITING

Botulinum Toxin for the Treatment of Involuntary Movement Disorders

NCT00001208

ACTIVE NOT RECRUITING Phase 1

Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)

NCT07204977

ACTIVE NOT RECRUITING Phase 2

Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Functional Movement Disorders

NCT05155059

ACTIVE NOT RECRUITING Phase 2

Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

NCT04742400

ACTIVE NOT RECRUITING

Clinical Laboratory Evaluation of Chronic Autonomic Failure

NCT03648905

ACTIVE NOT RECRUITING Phase 1

Deep Brain Stimulation Surgery for Focal Hand Dystonia

NCT02911103

ACTIVE NOT RECRUITING Phase 1

Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

NCT02362438

ACTIVE NOT RECRUITING

A Prospective Natural History Study of Patients With Syringomyelia

NCT01150708

ACTIVE NOT RECRUITING

Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease

NCT00005902

COMPLETED NA

Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory

NCT04694131

COMPLETED Early Phase 1

NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy

NCT04781309

COMPLETED

Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex

NCT04431011

COMPLETED NA

Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis

NCT04344470

COMPLETED NA

Pathophysiology of Focal Hand Dystonia

NCT03223623

COMPLETED Phase 1

Functional Connectivity as a Biomarker of rTMS

NCT03050801

COMPLETED

Cholinergic Receptor Imaging in Dystonia

NCT02689466

COMPLETED Phase 1

In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging

NCT02511028

COMPLETED Phase 1

Neural Basis of Decision-Making Deficits in Traumatic Brain Injury

NCT02169310

COMPLETED Phase 2

Efficacy of Levetiracetam in Oromandibular and Cranial Dystonia

NCT02199509

COMPLETED Phase 1

Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)

NCT02108002

COMPLETED Phase 2

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

NCT02019667

COMPLETED Early Phase 1

Effects of Hormone Stimulation on Brain Scans for Cushing s Disease

NCT01459237

COMPLETED Phase 1

Intravenous Norepinephrine for Orthostatic Hypotension

NCT01285908

COMPLETED

Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients

NCT01222728

COMPLETED

Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study

NCT01143428

COMPLETED

The Influence of Sensory Stimuli on Gait Imagery in Patients With Freezing of Gait

NCT01071590

COMPLETED Phase 1

A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm

NCT00942851

COMPLETED

Biomarkers of Risk of Parkinson Disease

NCT00775853

COMPLETED

Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome

NCT00755339

COMPLETED

Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia

NCT00713414

COMPLETED

Movement of Epiglottis During Swallowing

NCT00475943

COMPLETED

Spaced Versus Massed Skill Learning

NCT00426465

COMPLETED

MRI of Alzheimer's Disease Imaging Amyloid Plaques in Persons With and Without Memory Problems

NCT00413621

COMPLETED

Motor Skill Learning in People With Parkinson's Disease

NCT00396942

COMPLETED

Enhancing Motor Task Training by Action Observation Watching Others Perform the Task

NCT00393432

COMPLETED

Muscle Contraction in Patients With Focal Hand Dystonia

NCT00376753

COMPLETED Phase 2

A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia

NCT00376506

COMPLETED Phase 2

Brain Stimulation to Treat Blepharospasm or Meige Syndrome

NCT00411255

COMPLETED

Electrical Brain Stimulation to Reduce Epileptic Seizures

NCT00344877

COMPLETED

Diffusion Tensor MRI to Distinguish Brain Tumor Recurrence From Radiation Necrosis

NCT00285324

COMPLETED Phase 2

Electrical Polarization of the Brain in Corticobasal Syndrome

NCT00273897

COMPLETED Phase 1

Deep Brain Stimulation to Treat Cervical Dystonia

NCT00132340

COMPLETED

Interhemispheric Plasticity in Humans

NCT00120666

COMPLETED Phase 2

Double Blind Trial of DC Polarization in FTD

NCT00117858

COMPLETED

MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle

NCT00117221

COMPLETED

Motor Performance in Chronic Stroke Patients

NCT00110175

COMPLETED Phase 1

Nitrite Infusion in Healthy Volunteers

NCT00103025

COMPLETED

Brain Function in Focal Dystonia

NCT00102999

COMPLETED Phase 2

Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor

NCT00102596

COMPLETED Phase 4

Replagal Enzyme Replacement Therapy for Adults With Fabry Disease

NCT00097890

COMPLETED

The Functional Anatomy of Personality Trait Knowledge: An fMRI Study

NCT00095407

COMPLETED Phase 2

Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance

NCT00093860

COMPLETED

Treatment Study of Frontotemporal Dementia

NCT00088751

COMPLETED Phase 3

Comparison of TransMID vs Standard Treatment of Cancerous Brain Tumors

NCT00088400

COMPLETED

Brain Electrical Stimulation to Enhance Recovery After Stroke

NCT00085657

Phase Distribution

PhaseTrial count
Phase 1 21
Phase 2 27
Phase 3 2
Phase 4 4

What the Pipeline for National Institute of Neurological Disorders and Stroke (NINDS) Shows

According to the ClinicalTrials.gov registry, National Institute of Neurological Disorders and Stroke (NINDS) is linked to 339 US clinical trials across every stage of research activity. Of those, 210 studies are currently recruiting — about 62% of the sponsor's indexed portfolio — and 121 are already marked complete, representing roughly 36% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for National Institute of Neurological Disorders and Stroke (NINDS) reports 6 late-stage studies (Phase 3 and Phase 4 combined) and 48 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for National Institute of Neurological Disorders and Stroke (NINDS) is Healthy with 23 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial