National Institute of Neurological Disorders and Stroke (NINDS)

567 total trials 48 currently recruiting 467 completed

National Institute of Neurological Disorders and Stroke (NINDS) sponsors 567 registered US clinical trials on ClinicalTrials.gov, 48 of them currently recruiting, and 467 completed. 16 of these trials are in Phase 3-4 (later-stage) and 158 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 23 trials.

Trial Pipeline

567 total, page 1 of 12

RECRUITING Phase 1

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

NCT07416188

RECRUITING Phase 2

Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study

NCT07511049

RECRUITING

Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

NCT06615973

RECRUITING

Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques

NCT07137442

RECRUITING

Predicting Future Errors During Skill Performance

NCT06707207

RECRUITING NA

DDAVP for Pituitary Adenoma

NCT04569591

RECRUITING

A Prospective Natural History and Outcome Measure Validation Study of Congenital Myasthenic Syndromes

NCT06630650

RECRUITING Early Phase 1

Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort

NCT06472622

RECRUITING

Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection

NCT06577467

RECRUITING Phase 1

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

NCT02531880

RECRUITING

Data Collection of Standard Care of Patients in the EMG Section

NCT05041387

RECRUITING

Ultra-Low Field (ULF) Point-of-Care (POC) MRI System for Brain Morphology and Pathology

NCT06203626

RECRUITING Phase 1

Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy

NCT05849467

RECRUITING

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

NCT05375812

RECRUITING

Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects

NCT05604534

RECRUITING

Natural History Protocol for Movement Disorders

NCT05413291

RECRUITING

Investigational Use of Neuromuscular Ultrasound

NCT05237973

RECRUITING

Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health

NCT04573062

RECRUITING

Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)

NCT04944940

RECRUITING Phase 1

Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

NCT04799288

RECRUITING

The Beneficial Effects of Naps on Motor Learning

NCT04312126

RECRUITING

Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing

NCT04394871

RECRUITING NA

Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery

NCT03678389

RECRUITING

Influence of Brain Oscillation-Dependent TMS on Motor Function

NCT03288220

RECRUITING

Investigating Epilepsy: Screening and Evaluation

NCT03478852

RECRUITING

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

NCT03225144

RECRUITING Phase 2

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

NCT02784210

RECRUITING

Pathological Basis of MRI Signal Changes in Multiple Sclerosis

NCT02659956

RECRUITING

Tumor Related Epilepsy

NCT02639325

RECRUITING

Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

NCT02629107

RECRUITING

Inflammatory and Infectious Diseases of the Nervous System

NCT02435810

RECRUITING NA

Deep Brain Stimulation Therapy in Movement Disorders

NCT02119611

RECRUITING

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

NCT02107989

RECRUITING

Thinking and Memory Problems in People With HIV

NCT01875588

RECRUITING NA

Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers

NCT01900132

RECRUITING

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

NCT01730131

RECRUITING

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

NCT01568658

RECRUITING NA

Deep Brain Stimulation Surgery for Movement Disorders

NCT01581580

RECRUITING

Surgery as a Treatment for Medically Intractable Epilepsy

NCT01273129

RECRUITING

Natural History Study of Patients With Neurofibromatosis Type 2

NCT00598351

RECRUITING

Evaluation and Treatment of Neurosurgical Disorders

NCT00060541

RECRUITING

Phenotype/Genotype Correlations in Movement Disorders

NCT00018889

RECRUITING

Natural History of Stroke: Cause and Development

NCT00009243

RECRUITING

Study of New Magnetic Resonance Imaging Methods of the Brain

NCT00004577

RECRUITING

Study of Inherited Neurological Disorders

NCT00004568

RECRUITING

Evaluation of Patients With HAM/TSP

NCT00001778

RECRUITING

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

NCT00001248

RECRUITING

Botulinum Toxin for the Treatment of Involuntary Movement Disorders

NCT00001208

ACTIVE NOT RECRUITING Phase 1

Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)

NCT07204977

ACTIVE NOT RECRUITING Phase 2

Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Functional Movement Disorders

NCT05155059

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 78
Phase 3 11
Phase 4 5

What the Pipeline for National Institute of Neurological Disorders and Stroke (NINDS) Shows

According to the ClinicalTrials.gov registry, National Institute of Neurological Disorders and Stroke (NINDS) is linked to 567 US clinical trials across every stage of research activity. Of those, 48 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 467 are already marked complete, representing roughly 82% of the total.

The phase mix for National Institute of Neurological Disorders and Stroke (NINDS) reports 16 late-stage studies (Phase 3 and Phase 4 combined) and 158 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute of Neurological Disorders and Stroke (NINDS) is Healthy with 23 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.