National Institute of Neurological Disorders and Stroke (NINDS)
Trial Pipeline
Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke
NCT06615973
Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques
NCT07137442
Predicting Future Errors During Skill Performance
NCT06707207
DDAVP for Pituitary Adenoma
NCT04569591
A Prospective Natural History and Outcome Measure Validation Study of Congenital Myasthenic Syndromes
NCT06630650
Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
NCT06472622
Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection
NCT06577467
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
NCT02531880
Data Collection of Standard Care of Patients in the EMG Section
NCT05041387
Ultra-Low Field (ULF) Point-of-Care (POC) MRI System for Brain Morphology and Pathology
NCT06203626
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy
NCT05849467
NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)
NCT05375812
Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects
NCT05604534
Natural History Protocol for Movement Disorders
NCT05413291
Investigational Use of Neuromuscular Ultrasound
NCT05237973
Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health
NCT04573062
Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)
NCT04944940
Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis
NCT04799288
The Beneficial Effects of Naps on Motor Learning
NCT04312126
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing
NCT04394871
Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery
NCT03678389
Influence of Brain Oscillation-Dependent TMS on Motor Function
NCT03288220
Investigating Epilepsy: Screening and Evaluation
NCT03478852
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
NCT03225144
Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques
NCT02784210
Pathological Basis of MRI Signal Changes in Multiple Sclerosis
NCT02659956
Tumor Related Epilepsy
NCT02639325
Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
NCT02629107
Inflammatory and Infectious Diseases of the Nervous System
NCT02435810
Deep Brain Stimulation Therapy in Movement Disorders
NCT02119611
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
NCT02107989
Thinking and Memory Problems in People With HIV
NCT01875588
Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers
NCT01900132
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
NCT01730131
Genetic and Physical Study of Childhood Nerve and Muscle Disorders
NCT01568658
Deep Brain Stimulation Surgery for Movement Disorders
NCT01581580
Surgery as a Treatment for Medically Intractable Epilepsy
NCT01273129
Natural History Study of Patients With Neurofibromatosis Type 2
NCT00598351
Evaluation and Treatment of Neurosurgical Disorders
NCT00060541
Phenotype/Genotype Correlations in Movement Disorders
NCT00018889
Natural History of Stroke: Cause and Development
NCT00009243
Study of New Magnetic Resonance Imaging Methods of the Brain
NCT00004577
Study of Inherited Neurological Disorders
NCT00004568
Evaluation of Patients With HAM/TSP
NCT00001778
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
NCT00001248
Botulinum Toxin for the Treatment of Involuntary Movement Disorders
NCT00001208
Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)
NCT07204977
Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Functional Movement Disorders
NCT05155059
Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
NCT04742400
Clinical Laboratory Evaluation of Chronic Autonomic Failure
NCT03648905
Deep Brain Stimulation Surgery for Focal Hand Dystonia
NCT02911103
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy
NCT02362438
A Prospective Natural History Study of Patients With Syringomyelia
NCT01150708
Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease
NCT00005902
Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory
NCT04694131
NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy
NCT04781309
Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex
NCT04431011
Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis
NCT04344470
Pathophysiology of Focal Hand Dystonia
NCT03223623
Functional Connectivity as a Biomarker of rTMS
NCT03050801
Cholinergic Receptor Imaging in Dystonia
NCT02689466
In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging
NCT02511028
Neural Basis of Decision-Making Deficits in Traumatic Brain Injury
NCT02169310
Efficacy of Levetiracetam in Oromandibular and Cranial Dystonia
NCT02199509
Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)
NCT02108002
Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency
NCT02019667
Effects of Hormone Stimulation on Brain Scans for Cushing s Disease
NCT01459237
Intravenous Norepinephrine for Orthostatic Hypotension
NCT01285908
Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients
NCT01222728
Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study
NCT01143428
The Influence of Sensory Stimuli on Gait Imagery in Patients With Freezing of Gait
NCT01071590
A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm
NCT00942851
Biomarkers of Risk of Parkinson Disease
NCT00775853
Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome
NCT00755339
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia
NCT00713414
Movement of Epiglottis During Swallowing
NCT00475943
Spaced Versus Massed Skill Learning
NCT00426465
MRI of Alzheimer's Disease Imaging Amyloid Plaques in Persons With and Without Memory Problems
NCT00413621
Motor Skill Learning in People With Parkinson's Disease
NCT00396942
Enhancing Motor Task Training by Action Observation Watching Others Perform the Task
NCT00393432
Muscle Contraction in Patients With Focal Hand Dystonia
NCT00376753
A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia
NCT00376506
Brain Stimulation to Treat Blepharospasm or Meige Syndrome
NCT00411255
Electrical Brain Stimulation to Reduce Epileptic Seizures
NCT00344877
Diffusion Tensor MRI to Distinguish Brain Tumor Recurrence From Radiation Necrosis
NCT00285324
Electrical Polarization of the Brain in Corticobasal Syndrome
NCT00273897
Deep Brain Stimulation to Treat Cervical Dystonia
NCT00132340
Interhemispheric Plasticity in Humans
NCT00120666
Double Blind Trial of DC Polarization in FTD
NCT00117858
MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle
NCT00117221
Motor Performance in Chronic Stroke Patients
NCT00110175
Nitrite Infusion in Healthy Volunteers
NCT00103025
Brain Function in Focal Dystonia
NCT00102999
Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor
NCT00102596
Replagal Enzyme Replacement Therapy for Adults With Fabry Disease
NCT00097890
The Functional Anatomy of Personality Trait Knowledge: An fMRI Study
NCT00095407
Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance
NCT00093860
Treatment Study of Frontotemporal Dementia
NCT00088751
Comparison of TransMID vs Standard Treatment of Cancerous Brain Tumors
NCT00088400
Brain Electrical Stimulation to Enhance Recovery After Stroke
NCT00085657
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 21 |
| Phase 2 | 27 |
| Phase 3 | 2 |
| Phase 4 | 4 |
Therapeutic Areas
What the Pipeline for National Institute of Neurological Disorders and Stroke (NINDS) Shows
According to the ClinicalTrials.gov registry, National Institute of Neurological Disorders and Stroke (NINDS) is linked to 339 US clinical trials across every stage of research activity. Of those, 210 studies are currently recruiting — about 62% of the sponsor's indexed portfolio — and 121 are already marked complete, representing roughly 36% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for National Institute of Neurological Disorders and Stroke (NINDS) reports 6 late-stage studies (Phase 3 and Phase 4 combined) and 48 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for National Institute of Neurological Disorders and Stroke (NINDS) is Healthy with 23 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.