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2026 data Public-data reference. official source

Epithelial Ovarian Cancer

Open-data reference.

42 US clinical trials · 18 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 1,100 participants

AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer

AstraZeneca

NCT07218809

RECRUITING Phase 3 500 participants

Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer

Imunon

NCT06915025

RECRUITING Phase 1 430 participants

Study of AVZO-021 in Patients With Advanced Solid Tumors

Avenzo Therapeutics

NCT05867251

RECRUITING Phase 1 292 participants

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Bicara Therapeutics

NCT04429542

RECRUITING Phase 2 230 participants

CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

TORL Biotherapeutics

NCT06690775

RECRUITING Phase 1 140 participants

A Study of ZN-c3 in Patients With Ovarian Cancer

K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals

NCT04516447

RECRUITING Phase 2 140 participants

A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

AbbVie

NCT06890338

RECRUITING Phase 1 120 participants

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

858 Therapeutics

NCT06395519

RECRUITING Phase 2 90 participants

A Study of Isoquercetin in People With Ovarian Cancer

Memorial Sloan Kettering Cancer Center

NCT07303894

RECRUITING Phase 1 90 participants

A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

Regeneron Pharmaceuticals

NCT06469281

RECRUITING Phase 1 71 participants

[18F]FPyQCP PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications

Blue Earth Diagnostics

NCT07432633

RECRUITING Phase 1 70 participants

T-regulatory Cell Depletion with E7777 Combined with Pembrolizumab in Recurrent or Metastatic Solid Tumors

Alexander B Olawaiye, MD

NCT05200559

RECRUITING Phase 1 70 participants

CT-95 in Advanced Cancers Associated With Mesothelin Expression

Context Therapeutics

NCT06756035

RECRUITING Phase 1 60 participants

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

BioEclipse Therapeutics

NCT04282044

RECRUITING NA 35 participants

A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)

Memorial Sloan Kettering Cancer Center

NCT05429970

RECRUITING Phase 1 27 participants

Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells

UNC Lineberger Comprehensive Cancer Center

NCT06305299

RECRUITING Phase 1 22 participants

Prehabilitation for EOC, Fallopian Tube, Primary Peritoneal Carcinoma and Pancreatic Cancer w/ NACT

Case Comprehensive Cancer Center

NCT06412510

RECRUITING NA 20 participants

Fasting During Neoadjuvant Chemotherapy in Patient With Epithelial Ovarian Cancer

Case Comprehensive Cancer Center

NCT06386887

ACTIVE NOT RECRUITING Phase 1 1,410 participants

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Klus Pharma

NCT04152499

ACTIVE NOT RECRUITING Phase 3 1,097 participants

A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy

pharmaand

NCT03522246

ACTIVE NOT RECRUITING Phase 1 141 participants

A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies

23andMe

NCT05199272

ACTIVE NOT RECRUITING Phase 1 138 participants

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

Toray Industries

NCT03872947

ACTIVE NOT RECRUITING Phase 1 130 participants

Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors

Cybrexa Therapeutics

NCT04902872

ACTIVE NOT RECRUITING Phase 1 130 participants

Study of IMNN-001 (Also Known as GEN-1) With NACT for Treatment of Ovarian Cancer (OVATION 2)

Imunon

NCT03393884

ACTIVE NOT RECRUITING Phase 1 70 participants

TH1902 in Patients With Advanced Solid Tumors

Theratechnologies

NCT04706962

ACTIVE NOT RECRUITING Phase 1 51 participants

ITIL-306 in Advanced Solid Tumors

Instil Bio

NCT05397093

ACTIVE NOT RECRUITING Phase 2 32 participants

HOT: HIPEC in Ovarian Cancer as Initial Treatment

Mercy Medical Center

NCT02124421

ACTIVE NOT RECRUITING Phase 1 4 participants

Phase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian

UNC Lineberger Comprehensive Cancer Center

NCT04670068

COMPLETED Phase 2 491 participants

A Study of Rucaparib in Patients With Platinum-Sensitive, Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARIEL2)

pharmaand

NCT01891344

COMPLETED Phase 3 453 participants

A Study of Mirvetuximab Soravtansine vs. Investigator's Choice (IC) of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha (FRα) Expression

AbbVie

NCT04209855

COMPLETED Phase 2 297 participants

VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Celgene

NCT01666444

COMPLETED Phase 1 269 participants

Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

Exelixis

NCT04925284

COMPLETED Phase 3 106 participants

A Study of Mirvetuximab Soravtansine in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression

ImmunoGen

NCT04296890

COMPLETED Phase 2 78 participants

Evaluation of Weekly Ixabepilone With or Without Biweekly Bevacizumab

Yale University

NCT03093155

COMPLETED NA 50 participants

Surgical Trial Comparing LIGASURE Assisted Recto-Sigmoid Resection and Omentectomy Compared to Stand

University of Utah

NCT01549925

COMPLETED Phase 2 48 participants

Bevacizumab With Abraxane in Patients With Recurrent Ovarian/ Peritoneal Cancer

Accelerated Community Oncology Research Network

NCT00407563

COMPLETED Early Phase 1 39 participants

A Study of Pembrolizumab on the Tumoral Immunoprofile of Gynecologic Cancers

AA Secord

NCT02728830

COMPLETED Phase 1 37 participants

Phase 1b Study of a Cancer Vaccine to Treat Patients With Advanced Stage Ovarian, Fallopian or Peritoneal Cancer

ImmunoVaccine Technologies, Inc. (IMV Inc.)

NCT03332576

COMPLETED Phase 2 32 participants

Neoadjuvant Therapy for Ovarian Cancer

Jason D. Wright

NCT01146795

COMPLETED Phase 1 18 participants

Study of Safety & Biological Activity of IP IMNN-001 (also Known As GEN-1) with Neoadjuvant Chemo in Ovarian Cancer

Imunon

NCT02480374

COMPLETED Phase 1 15 participants

Safety Study of Farletuzumab, Carboplatin and Pegylated Liposomal Doxorubicin (PLD) to Treat Platinum-sensitive Ovarian Cancer

Morphotek

NCT01004380

COMPLETED Phase 2 9 participants

Ovarian Cancer Vaccine for Patients Who Have Progressed During the CAN-003 Study

Prima BioMed

NCT01617629

Phase Distribution

PhaseTrial count
Early Phase 1 24
Phase 2 10
Phase 3 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Epithelial Ovarian Cancer Trial Landscape

ClinicalTrials.gov lists 42 US studies indexed under Epithelial Ovarian Cancer, and 18 of those are currently open to recruitment — roughly 43% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Epithelial Ovarian Cancer shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 34 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Epithelial Ovarian Cancer is led by Imunon with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 42 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Epithelial Ovarian Cancer?

PlainTrial tracks 42 US clinical trials for Epithelial Ovarian Cancer, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Epithelial Ovarian Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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