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Pain, Postoperative clinical trials
Every US clinical trial registered for Pain, Postoperative — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
109 US clinical trials · 44 currently recruiting
The research picture
Pain, Postoperative has 109 registered US clinical trials, 44 of them open to new participants right now — about 40% of the total.
- 44
- recruiting participants now
- 40%
- of trials open to enrollment
- 50
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Mayo Clinic
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Washington University School of Medicine
NCT05991453
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
University of Michigan
NCT05722002
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
Duke University
NCT06576830
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
Weill Medical College of Cornell University
NCT06094257
Continuous Infusions vs Scheduled Bolus Infusions
Stanford University
NCT03230565
TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant
University of California, Davis
NCT03737604
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
Hospital for Special Surgery, New York
NCT05058287
Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery
Sanford Health
NCT03858231
Comparison of Methods for Recording Post Operative Pain
University of California, San Francis
NCT06206148
The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
University of Southern California
NCT05746143
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
Columbia University
NCT06456268
Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
Stanford University
NCT04676802
Latinx Children and Surgery
University of California, Irvine
NCT06020677
Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery
Loyola University
NCT05824832
Oral Methadone in Cardiac Surgery
Mayo Clinic
NCT07221617
Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population
Texas Scottish Rite Hospital for Children
NCT06559215
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Jenna-Leigh Wilson
NCT06949826
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
Loma Linda University
NCT04860141
Scheduled or As Needed Pain Regimen?
Cape Fear Valley Health System
NCT06495632
Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy
University of California, Los Angeles
NCT06189781
Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery
Northwestern University
NCT05351229
Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures
Wake Forest University Health Sciences
NCT05415384
Opioid-Free Orthopaedics
Emory University
NCT04659317
Quadratus Lumborum Block for Total Hip Arthroplasty
University of California, Los Angeles
NCT05247255
Depo-Medrol on Psoas After LLIF
Hardeep Singh
NCT05929755
Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy
University of Michigan
NCT06384664
IPACK on Early Pain Scores After ACL Reconstruction
Loyola University
NCT05985629
Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery
Stanford University
NCT04109638
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
Boston University
NCT06757075
Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain
University of Kansas Medical Center
NCT03854344
Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries
Northwell Health
NCT06379425
Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery
University of Massachusetts, Worcester
NCT06528288
Magnesium as an Adjuvant Agent for Postoperative Pain
University Hospitals Cleveland Medical Center
NCT05947760
Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery
Stony Brook University
NCT06570577
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Boston Children's Hospital
NCT04439552
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
University of California, Davis
NCT04724252
Anesthetic Optimization in Pediatric LeFort Surgeries
Johns Hopkins University
NCT05260320
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
University of Virginia
NCT06387303
Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy
Milton S. Hershey Medical Center
NCT03737292
Dance Study for Post-surgical Pain in Breast Cancer Survivors
Dana-Farber Cancer Institute
NCT06758102
Opioid Dispenser for Microdiscectomy/Laminectomy
Hospital for Special Surgery, New York
NCT06358040
Patient Controlled Administration of Liquid Acetaminophen
Yale University
NCT06498713
Transcutaneous Auricular Neurostimulation After Lumbar Surgery
University of Texas Southwestern Medical Center
NCT06100172
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
University of California, San Francis
NCT04144972
Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery
Children's Hospital Medical Center, Cincinnati
NCT04031716
SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty
Scripps Health
NCT04247646
Reduced Opioid Prescription After Laparoscopic Hysterectomy
Johns Hopkins University
NCT05548582
Intercostal Nerve Cryotherapy in Patients Undergoing Minimally Invasive Pulmonary Resection
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
NCT05348447
Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial
University of Missouri, Kansas City
NCT04680221
Exparel Injection for Postoperative Orbital Pain
Mayo Clinic
NCT02381353
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
Beth Israel Deaconess Medical Center
NCT05283980
A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty
Ohio State University
NCT03498261
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
Campbell Clinic
NCT05099276
Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
University of California, San Francis
NCT05593237
Blood Ropivacaine Concentrations Following Chest Wall Nerve Block Continuous Infusion
Boston Children's Hospital
NCT02860091
Personalized Prediction of Persistent Postsurgical Pain
Washington University School of Medicine
NCT04864275
Healthcare Provider Behavior and Children's Perioperative Distress
University of California, Irvine
NCT01878747
Evaluation of an Interactive Opioid Risk Education Program (STOMP) for Parents
University of Michigan
NCT03287622
Efficacy and Safety of IV Diclofenac (DIC075V) for Pain After Abdominal or Pelvic Surgery
Javelin Pharmaceuticals
NCT00448110
Evaluate Efficacy and Safety of Extended Release (ER) Naproxen Sodium
Bayer
NCT01389284
Opioid Use After Thyroid and Parathyroid Surgeries
The Methodist Hospital Research Institute
NCT04955444
The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
University of California, San Francis
NCT03196505
Efficacy of Transversus Abdominis Plane Block Versus Local Injection of Pain Medication
Liberman, Eric, D.O.
NCT02314104
Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery
Xanodyne Pharmaceuticals
NCT00375934
Optimizing Catheter Insertion Technique for Ultrasound-guided Continuous Peripheral Nerve Blocks
VA Palo Alto Health Care System
NCT01459523
Evaluation of Preoperative N1539 in Total Knee Arthroplasty
Baudax Bio
NCT03434275
Expectations and Pain Control Advancement In surgeRy: The REPAIR Trial
University of New Mexi
NCT03726476
Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval
Massachusetts General Hospital
NCT03073980
IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty
Hospital for Special Surgery, New York
NCT03020966
Transcutaneous Electrical Nerve Stimulation During Outpatient Endometrial Biopsy
Duke University
NCT05472740
Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure.
Indiana University
NCT03151434
Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy
University of California, Los Angeles
NCT03294109
Mobile Educations Effect on Pain Outcomes
Mayo Clinic
NCT03301610
Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures
Indiana University
NCT03859635
Perioperative Pregabalin in Ureteroscopy
University of Missouri-Columbia
NCT04122196
Intraoperative Liposomal Bupivacaine vs. Bupivacaine for Total Hip Replacement Pain Management
American Hip Institute
NCT03001453
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Cedars-Sinai Medical Center
NCT03723447
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
Pinnacle Health System
NCT00508976
Preemptive Local Anesthesia in Vaginal Surgery
Mayo Clinic
NCT00318292
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
University of California, Irvine
NCT02086123
Single Shot Liposomal Bupivicaine in Rotator Cuff Surgery
Indiana University
NCT03822182
Liposomal Bupivacaine Versus Interscalene Nerve Block
University of Cincinnati
NCT03929146
Methadone Versus Morphine for Orthopedic Surgery Patients
University of Louisville
NCT00892606
Pudendal Nerve Block in Vaginal Surgery
MetroHealth Medical Center
NCT04198714
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
The Medicines Company
NCT02395653
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
University of Michigan
NCT03577730
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
Children's Hospital of Philadelphia
NCT01394718
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The University of Texas Health Science Center, Houston
NCT04790812
Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty
Kevin King, DO
NCT02453321
BRIDGE Percutaneous Nerve Stimulation for Cesarean Delivery Pain Control
Grace Lim, MD, MS
NCT04365465
Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty
Wake Forest University Health Sciences
NCT02991404
Evaluate the Efficacy and Safety of VVZ-149 Injections for the Treatment of Postoperative Pain Following Bunionectomy
Vivozon
NCT03997812
The Effects of a Music Therapist Designed Listening Program on Intraoperative Vitrectomy
Vanderbilt University Medical Center
NCT03147235
Effect of Cold Therapy Implementation on Multi-modal Postoperative Pain Management
Cleveland Clinic Florida
NCT03129464
Combination Dexamethasone and Bupivacaine Pain Control in Reduction Mammaplasty
Temple University
NCT04919317
The Effect Of An Anesthetic Procedure On Post Operative Pain Management In Carpal Tunnel Release
University of South Florida
NCT03729375
Study of Oral Morphine Sulfate Administration in Pediatric Subjects
West-Ward Pharmaceutical
NCT03429400
Post-Op Lidocaine Patch
Oregon Health and Science University
NCT03500211
Management of Post-Tonsillectomy Pain in Pediatric Patients
Washington University School of Medicine
NCT04551196
Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.
University of Tennessee
NCT03027661
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 10 |
| Phase 3 | 14 |
| Phase 4 | 36 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pain, Postoperative Trial Landscape
ClinicalTrials.gov lists 109 US studies indexed under Pain, Postoperative, and 44 of those are currently open to recruitment — roughly 40% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Pain, Postoperative shows 50 late-stage studies (Phase 3 and Phase 4 combined) alongside 17 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Pain, Postoperative is led by Mayo Clinic with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pain, Postoperative?
PlainTrial tracks 109 US clinical trials for Pain, Postoperative, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pain, Postoperative?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.