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Pain, Postoperative: later-stage trial registry
46 of 114 indexed Pain, Postoperative trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #112 of 28,707 conditions by registered trial count.
114 US clinical trials · 46 currently recruiting · #112 of 28,707 conditions by registered trial count
Pain, Postoperative: 114 US clinical trials tracked, 46 recruiting.
Pain, Postoperative is the subject of 114 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 53 are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most active sponsor is University of Michigan, running 5 of these trials.
Enrollment posture brief
Registry condition pain-postoperative
OPEN 46 | RECR 40% | LATE 53 | EARLY 18 | RANK #112 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Quality of Life (40% recruiting · 109 trials)
Pain, Postoperative lists 46 open slots (40% of 114 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain, Postoperative on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain, Postoperative is recruiting above its size-band peers.
46 of 114 indexed trials (40.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain, Postoperative trials is spread across many organizations.
University of Michigan accounts for 5 of 114 trials (4.4%). 78 distinct sponsors appear on at least one study for this condition label.
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Typical Pain, Postoperative enrolment sits around 80 participants.
Median target enrolment is 80 among the 114 trials that report a genuine target (sentinel values excluded). 67 of those (58.8%) plan for fewer than 100 participants.
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Pain, Postoperative research is mostly interventional.
110 interventional and 4 observational studies make up this index (96.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
114 total, page 1 of 3
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Washington University School of Medicine
NCT05991453
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
University of Michigan
NCT05722002
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
University of Michigan
NCT06671002
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
Duke University
NCT06576830
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
Weill Medical College of Cornell University
NCT06094257
Continuous Infusions vs Scheduled Bolus Infusions
Stanford University
NCT03230565
TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant
University of California, Davis
NCT03737604
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
Hospital for Special Surgery, New York
NCT05058287
Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery
Sanford Health
NCT03858231
Comparison of Methods for Recording Post Operative Pain
University of California, San Francisco
NCT06206148
The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
University of Southern California
NCT05746143
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
Columbia University
NCT06456268
Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
Stanford University
NCT04676802
Latinx Children and Surgery
University of California, Irvine
NCT06020677
Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery
Loyola University
NCT05824832
Oral Methadone in Cardiac Surgery
Mayo Clinic
NCT07221617
Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population
Texas Scottish Rite Hospital for Children
NCT06559215
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Jenna-Leigh Wilson
NCT06949826
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
Loma Linda University
NCT04860141
Scheduled or As Needed Pain Regimen?
Cape Fear Valley Health System
NCT06495632
Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy
University of California, Los Angeles
NCT06189781
Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery
Northwestern University
NCT05351229
Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures
Wake Forest University Health Sciences
NCT05415384
Opioid-Free Orthopaedics
Emory University
NCT04659317
Quadratus Lumborum Block for Total Hip Arthroplasty
University of California, Los Angeles
NCT05247255
Depo-Medrol on Psoas After LLIF
Hardeep Singh
NCT05929755
Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy
University of Michigan
NCT06384664
IPACK on Early Pain Scores After ACL Reconstruction
Loyola University
NCT05985629
Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery
Stanford University
NCT04109638
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
Boston University
NCT06757075
Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain
University of Kansas Medical Center
NCT03854344
Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries
Northwell Health
NCT06379425
Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery
University of Massachusetts, Worcester
NCT06528288
Magnesium as an Adjuvant Agent for Postoperative Pain
University Hospitals Cleveland Medical Center
NCT05947760
Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery
Stony Brook University
NCT06570577
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Boston Children's Hospital
NCT04439552
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
University of California, Davis
NCT04724252
Anesthetic Optimization in Pediatric LeFort Surgeries
Johns Hopkins University
NCT05260320
Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft
Marquette University
NCT05919745
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
University of Virginia
NCT06387303
Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy
Milton S. Hershey Medical Center
NCT03737292
Dance Study for Post-surgical Pain in Breast Cancer Survivors
Dana-Farber Cancer Institute
NCT06758102
Opioid Dispenser for Microdiscectomy/Laminectomy
Hospital for Special Surgery, New York
NCT06358040
Patient Controlled Administration of Liquid Acetaminophen
Yale University
NCT06498713
Transcutaneous Auricular Neurostimulation After Lumbar Surgery
University of Texas Southwestern Medical Center
NCT06100172
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
University of California, San Francisco
NCT04144972
Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery
Children's Hospital Medical Center, Cincinnati
NCT04031716
SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty
Scripps Health
NCT04247646
Reduced Opioid Prescription After Laparoscopic Hysterectomy
Johns Hopkins University
NCT05548582
Intercostal Nerve Cryotherapy in Patients Undergoing Minimally Invasive Pulmonary Resection
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
NCT05348447
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 11 |
| Phase 3 | 15 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain, Postoperative records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain, Postoperative trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain, Postoperative page
114 registered trials, 46 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 46 Pain, Postoperative trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Michigan sponsors the most Pain, Postoperative trials on record, review their full trial history before evaluating a specific study. See University of Michigan's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain, Postoperative condition card totals 114 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.