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Pain, Postoperative clinical trials
44 of 109 indexed Pain, Postoperative trials are currently recruiting.
109 US clinical trials · 44 currently recruiting
Pain, Postoperative is the subject of 109 registered US clinical trials on ClinicalTrials.gov, 44 of them currently open to new participants. 50 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 5 of these trials.
The research picture
Pain, Postoperative has 109 registered US clinical trials, 44 of them open to new participants right now, about 40% of the total.
- 44
- recruiting participants now
- 40%
- of trials open to enrollment
- 50
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Mayo Clinic
Active & Recent Trials
109 total, page 1 of 3
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Washington University School of Medicine
NCT05991453
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
University of Michigan
NCT05722002
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
Duke University
NCT06576830
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
Weill Medical College of Cornell University
NCT06094257
Continuous Infusions vs Scheduled Bolus Infusions
Stanford University
NCT03230565
TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant
University of California, Davis
NCT03737604
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
Hospital for Special Surgery, New York
NCT05058287
Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery
Sanford Health
NCT03858231
Comparison of Methods for Recording Post Operative Pain
University of California, San Francisco
NCT06206148
The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
University of Southern California
NCT05746143
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)
Columbia University
NCT06456268
Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
Stanford University
NCT04676802
Latinx Children and Surgery
University of California, Irvine
NCT06020677
Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery
Loyola University
NCT05824832
Oral Methadone in Cardiac Surgery
Mayo Clinic
NCT07221617
Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population
Texas Scottish Rite Hospital for Children
NCT06559215
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Jenna-Leigh Wilson
NCT06949826
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
Loma Linda University
NCT04860141
Scheduled or As Needed Pain Regimen?
Cape Fear Valley Health System
NCT06495632
Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy
University of California, Los Angeles
NCT06189781
Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery
Northwestern University
NCT05351229
Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures
Wake Forest University Health Sciences
NCT05415384
Opioid-Free Orthopaedics
Emory University
NCT04659317
Quadratus Lumborum Block for Total Hip Arthroplasty
University of California, Los Angeles
NCT05247255
Depo-Medrol on Psoas After LLIF
Hardeep Singh
NCT05929755
Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy
University of Michigan
NCT06384664
IPACK on Early Pain Scores After ACL Reconstruction
Loyola University
NCT05985629
Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery
Stanford University
NCT04109638
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
Boston University
NCT06757075
Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain
University of Kansas Medical Center
NCT03854344
Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries
Northwell Health
NCT06379425
Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery
University of Massachusetts, Worcester
NCT06528288
Magnesium as an Adjuvant Agent for Postoperative Pain
University Hospitals Cleveland Medical Center
NCT05947760
Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery
Stony Brook University
NCT06570577
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Boston Children's Hospital
NCT04439552
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
University of California, Davis
NCT04724252
Anesthetic Optimization in Pediatric LeFort Surgeries
Johns Hopkins University
NCT05260320
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
University of Virginia
NCT06387303
Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy
Milton S. Hershey Medical Center
NCT03737292
Dance Study for Post-surgical Pain in Breast Cancer Survivors
Dana-Farber Cancer Institute
NCT06758102
Opioid Dispenser for Microdiscectomy/Laminectomy
Hospital for Special Surgery, New York
NCT06358040
Patient Controlled Administration of Liquid Acetaminophen
Yale University
NCT06498713
Transcutaneous Auricular Neurostimulation After Lumbar Surgery
University of Texas Southwestern Medical Center
NCT06100172
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
University of California, San Francisco
NCT04144972
Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery
Children's Hospital Medical Center, Cincinnati
NCT04031716
SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty
Scripps Health
NCT04247646
Reduced Opioid Prescription After Laparoscopic Hysterectomy
Johns Hopkins University
NCT05548582
Intercostal Nerve Cryotherapy in Patients Undergoing Minimally Invasive Pulmonary Resection
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
NCT05348447
Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial
University of Missouri, Kansas City
NCT04680221
Exparel Injection for Postoperative Orbital Pain
Mayo Clinic
NCT02381353
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 10 |
| Phase 3 | 14 |
| Phase 4 | 36 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pain, Postoperative Trial Landscape
109 indexed Pain, Postoperative studies · 44 recruiting (40%).
Phase mix: 50 late (III/IV) vs 17 early (I/II).
Top sponsor: Mayo Clinic (5 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pain, Postoperative?
PlainTrial tracks 109 US clinical trials for Pain, Postoperative, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pain, Postoperative?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.