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ClinicalTrials.gov 44 recruiting now official registry

Pain, Postoperative clinical trials

44 of 109 indexed Pain, Postoperative trials are currently recruiting.

109 US clinical trials · 44 currently recruiting

Pain, Postoperative is the subject of 109 registered US clinical trials on ClinicalTrials.gov, 44 of them currently open to new participants. 50 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 5 of these trials.

The research picture

Pain, Postoperative has 109 registered US clinical trials, 44 of them open to new participants right now, about 40% of the total.

44
recruiting participants now
40%
of trials open to enrollment
50
in Phase 3–4 (later-stage)
5
top sponsor: Mayo Clinic
Phase 17Phase 210Phase 314Phase 436

Active & Recent Trials

109 total, page 1 of 3

RECRUITING NA 13,000 participants

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

Washington University School of Medicine

NCT05991453

RECRUITING Phase 4 900 participants

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

University of Michigan

NCT05722002

RECRUITING Phase 4 440 participants

Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia

Duke University

NCT06576830

RECRUITING 400 participants

Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients

Weill Medical College of Cornell University

NCT06094257

RECRUITING Phase 4 240 participants

Continuous Infusions vs Scheduled Bolus Infusions

Stanford University

NCT03230565

RECRUITING Phase 4 200 participants

TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant

University of California, Davis

NCT03737604

RECRUITING Phase 3 150 participants

Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression

Hospital for Special Surgery, New York

NCT05058287

RECRUITING Phase 4 148 participants

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

Sanford Health

NCT03858231

RECRUITING NA 147 participants

Comparison of Methods for Recording Post Operative Pain

University of California, San Francisco

NCT06206148

RECRUITING Phase 4 140 participants

The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

University of Southern California

NCT05746143

RECRUITING NA 130 participants

VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)

Columbia University

NCT06456268

RECRUITING Phase 2 121 participants

Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

Stanford University

NCT04676802

RECRUITING NA 120 participants

Latinx Children and Surgery

University of California, Irvine

NCT06020677

RECRUITING Phase 4 120 participants

Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

Loyola University

NCT05824832

RECRUITING Phase 4 100 participants

Oral Methadone in Cardiac Surgery

Mayo Clinic

NCT07221617

RECRUITING Phase 2 100 participants

Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population

Texas Scottish Rite Hospital for Children

NCT06559215

RECRUITING Phase 4 100 participants

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

Jenna-Leigh Wilson

NCT06949826

RECRUITING Phase 4 98 participants

Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.

Loma Linda University

NCT04860141

RECRUITING Phase 4 90 participants

Scheduled or As Needed Pain Regimen?

Cape Fear Valley Health System

NCT06495632

RECRUITING Phase 4 90 participants

Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy

University of California, Los Angeles

NCT06189781

RECRUITING Phase 4 90 participants

Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery

Northwestern University

NCT05351229

RECRUITING NA 80 participants

Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures

Wake Forest University Health Sciences

NCT05415384

RECRUITING Phase 3 80 participants

Opioid-Free Orthopaedics

Emory University

NCT04659317

RECRUITING Early Phase 1 80 participants

Quadratus Lumborum Block for Total Hip Arthroplasty

University of California, Los Angeles

NCT05247255

RECRUITING Phase 4 80 participants

Depo-Medrol on Psoas After LLIF

Hardeep Singh

NCT05929755

RECRUITING NA 80 participants

Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy

University of Michigan

NCT06384664

RECRUITING Phase 4 78 participants

IPACK on Early Pain Scores After ACL Reconstruction

Loyola University

NCT05985629

RECRUITING NA 76 participants

Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery

Stanford University

NCT04109638

RECRUITING Phase 4 75 participants

Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia

Boston University

NCT06757075

RECRUITING Phase 4 75 participants

Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain

University of Kansas Medical Center

NCT03854344

RECRUITING Phase 4 70 participants

Impact of Preoperative Opioid-free Multimodal Analgesia on Time to Trial of Void in Ambulatory Urogynecologic Surgeries

Northwell Health

NCT06379425

RECRUITING NA 66 participants

Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

University of Massachusetts, Worcester

NCT06528288

RECRUITING Phase 4 64 participants

Magnesium as an Adjuvant Agent for Postoperative Pain

University Hospitals Cleveland Medical Center

NCT05947760

RECRUITING NA 60 participants

Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery

Stony Brook University

NCT06570577

RECRUITING 60 participants

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Boston Children's Hospital

NCT04439552

RECRUITING Phase 2 60 participants

Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children

University of California, Davis

NCT04724252

RECRUITING NA 50 participants

Anesthetic Optimization in Pediatric LeFort Surgeries

Johns Hopkins University

NCT05260320

RECRUITING Early Phase 1 40 participants

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery

University of Virginia

NCT06387303

RECRUITING Phase 4 40 participants

Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy

Milton S. Hershey Medical Center

NCT03737292

RECRUITING NA 30 participants

Dance Study for Post-surgical Pain in Breast Cancer Survivors

Dana-Farber Cancer Institute

NCT06758102

RECRUITING NA 30 participants

Opioid Dispenser for Microdiscectomy/Laminectomy

Hospital for Special Surgery, New York

NCT06358040

RECRUITING Phase 1 24 participants

Patient Controlled Administration of Liquid Acetaminophen

Yale University

NCT06498713

RECRUITING NA 20 participants

Transcutaneous Auricular Neurostimulation After Lumbar Surgery

University of Texas Southwestern Medical Center

NCT06100172

RECRUITING NA 12 participants

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

University of California, San Francisco

NCT04144972

ACTIVE NOT RECRUITING NA 600 participants

Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery

Children's Hospital Medical Center, Cincinnati

NCT04031716

ACTIVE NOT RECRUITING NA 120 participants

SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty

Scripps Health

NCT04247646

ACTIVE NOT RECRUITING NA 120 participants

Reduced Opioid Prescription After Laparoscopic Hysterectomy

Johns Hopkins University

NCT05548582

ACTIVE NOT RECRUITING NA 110 participants

Intercostal Nerve Cryotherapy in Patients Undergoing Minimally Invasive Pulmonary Resection

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

NCT05348447

ACTIVE NOT RECRUITING Phase 4 97 participants

Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial

University of Missouri, Kansas City

NCT04680221

ACTIVE NOT RECRUITING Phase 4 88 participants

Exparel Injection for Postoperative Orbital Pain

Mayo Clinic

NCT02381353

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 10
Phase 3 14
Phase 4 36

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pain, Postoperative Trial Landscape

109 indexed Pain, Postoperative studies · 44 recruiting (40%).

Phase mix: 50 late (III/IV) vs 17 early (I/II).

Top sponsor: Mayo Clinic (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pain, Postoperative?

PlainTrial tracks 109 US clinical trials for Pain, Postoperative, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pain, Postoperative?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.