Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04439552 · ClinicalTrials.gov registry record
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
A clinical trial of Pain, Postoperative and Pain, Chronic, sponsored by Boston Children's Hospital.
- Recruiting
- Registry status
- 60
- Enrollment target
- 1
- Study location
NCT04439552: Recruiting study of Pain, Postoperative and Pain, Chronic, sponsored by Boston Children's Hospital.
NCT04439552 is a study of Pain, Postoperative and Pain, Chronic that is actively recruiting participants, run by Boston Children's Hospital. The registered enrollment target is 60 participants, below the 272-participant average among 113 other Pain, Postoperative trials with a reported enrollment target (78% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04439552, a study of Pain, Postoperative and Pain, Chronic, is actively recruiting participants, sponsored by Boston Children's Hospital.
- RECRUITING
- Registry status
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
Primary Outcome
Pain-related brain activation measured with fMRI.
Conditions Studied
Study Locations (1)
Massachusetts
- Boston Children's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2021-10-04 |
| Est. Completion | 2027-12 |
What NCT04439552 shows while recruiting
NCT04439552 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 272-participant average among 113 other Pain, Postoperative trials with a reported enrollment target (78% lower).
The record links to 8 conditions, with Pain, Postoperative appearing as the primary indexed condition, and to 0 interventions.
NCT04439552 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04439552 about?
NCT04439552 is a clinical study titled "fMRI and IVCM Cornea Microscopy of CXL in Keratoconus". Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
What is the current status of trial NCT04439552?
This trial is currently recruiting. The enrollment target is 60 participants. The study started on 2021-10-04. Estimated completion is 2027-12.
What conditions does trial NCT04439552 study?
This clinical trial studies the following conditions: Pain, Postoperative, Pain, Chronic, Pain, Acute, Keratoconus, Surgical Wound.
Who is sponsoring clinical trial NCT04439552?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04439552 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain, Postoperative
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04439552's enrollment target sits among peer trials
60 79th of 113 higher than 30 of 113 other Pain, Postoperative trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Postoperative trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures
RECRUITING · NA
-
Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression
RECRUITING · Phase 3
-
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
RECRUITING · Phase 4
-
Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery
RECRUITING · Phase 4
-
The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
RECRUITING · Phase 4
-
Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00576069 · 60 participants
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma
- NCT01297400 · 60 participants · Phase 2
Phase 2 Pilot Study of the Safety and Efficacy of Topical MW-III in Thermal Burns
- NCT01734122 · 60 participants
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
- NCT01804634 · 60 participants · Phase 2
Reduced Intensity Haploidentical BMT for High Risk Solid Tumors
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI