Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Pain, Postoperative clinical trials
44 of 109 indexed Pain, Postoperative trials are currently recruiting.
109 US clinical trials · 44 currently recruiting
Pain, Postoperative is the subject of 109 registered US clinical trials on ClinicalTrials.gov, 44 of them currently open to new participants. 50 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 5 of these trials.
The research picture
Pain, Postoperative has 109 registered US clinical trials, 44 of them open to new participants right now, about 40% of the total.
- 44
- recruiting participants now
- 40%
- of trials open to enrollment
- 50
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Mayo Clinic
Active & Recent Trials
109 total, page 2 of 3
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
Beth Israel Deaconess Medical Center
NCT05283980
A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty
Ohio State University
NCT03498261
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
Campbell Clinic
NCT05099276
Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
University of California, San Francisco
NCT05593237
Blood Ropivacaine Concentrations Following Chest Wall Nerve Block Continuous Infusion
Boston Children's Hospital
NCT02860091
Personalized Prediction of Persistent Postsurgical Pain
Washington University School of Medicine
NCT04864275
Healthcare Provider Behavior and Children's Perioperative Distress
University of California, Irvine
NCT01878747
Evaluation of an Interactive Opioid Risk Education Program (STOMP) for Parents
University of Michigan
NCT03287622
Efficacy and Safety of IV Diclofenac (DIC075V) for Pain After Abdominal or Pelvic Surgery
Javelin Pharmaceuticals
NCT00448110
Evaluate Efficacy and Safety of Extended Release (ER) Naproxen Sodium
Bayer
NCT01389284
Opioid Use After Thyroid and Parathyroid Surgeries
The Methodist Hospital Research Institute
NCT04955444
The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
University of California, San Francisco
NCT03196505
Efficacy of Transversus Abdominis Plane Block Versus Local Injection of Pain Medication
Liberman, Eric, D.O.
NCT02314104
Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery
Xanodyne Pharmaceuticals
NCT00375934
Optimizing Catheter Insertion Technique for Ultrasound-guided Continuous Peripheral Nerve Blocks
VA Palo Alto Health Care System
NCT01459523
Evaluation of Preoperative N1539 in Total Knee Arthroplasty
Baudax Bio
NCT03434275
Expectations and Pain Control Advancement In surgeRy: The REPAIR Trial
University of New Mexi
NCT03726476
Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval
Massachusetts General Hospital
NCT03073980
IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty
Hospital for Special Surgery, New York
NCT03020966
Transcutaneous Electrical Nerve Stimulation During Outpatient Endometrial Biopsy
Duke University
NCT05472740
Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure.
Indiana University
NCT03151434
Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy
University of California, Los Angeles
NCT03294109
Mobile Educations Effect on Pain Outcomes
Mayo Clinic
NCT03301610
Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures
Indiana University
NCT03859635
Perioperative Pregabalin in Ureteroscopy
University of Missouri-Columbia
NCT04122196
Intraoperative Liposomal Bupivacaine vs. Bupivacaine for Total Hip Replacement Pain Management
American Hip Institute
NCT03001453
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Cedars-Sinai Medical Center
NCT03723447
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
Pinnacle Health System
NCT00508976
Preemptive Local Anesthesia in Vaginal Surgery
Mayo Clinic
NCT00318292
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
University of California, Irvine
NCT02086123
Single Shot Liposomal Bupivicaine in Rotator Cuff Surgery
Indiana University
NCT03822182
Liposomal Bupivacaine Versus Interscalene Nerve Block
University of Cincinnati
NCT03929146
Methadone Versus Morphine for Orthopedic Surgery Patients
University of Louisville
NCT00892606
Pudendal Nerve Block in Vaginal Surgery
MetroHealth Medical Center
NCT04198714
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
The Medicines Company
NCT02395653
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
University of Michigan
NCT03577730
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
Children's Hospital of Philadelphia
NCT01394718
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The University of Texas Health Science Center, Houston
NCT04790812
Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty
Kevin King, DO
NCT02453321
BRIDGE Percutaneous Nerve Stimulation for Cesarean Delivery Pain Control
Grace Lim, MD, MS
NCT04365465
Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty
Wake Forest University Health Sciences
NCT02991404
Evaluate the Efficacy and Safety of VVZ-149 Injections for the Treatment of Postoperative Pain Following Bunionectomy
Vivozon
NCT03997812
The Effects of a Music Therapist Designed Listening Program on Intraoperative Vitrectomy
Vanderbilt University Medical Center
NCT03147235
Effect of Cold Therapy Implementation on Multi-modal Postoperative Pain Management
Cleveland Clinic Florida
NCT03129464
Combination Dexamethasone and Bupivacaine Pain Control in Reduction Mammaplasty
Temple University
NCT04919317
The Effect Of An Anesthetic Procedure On Post Operative Pain Management In Carpal Tunnel Release
University of South Florida
NCT03729375
Study of Oral Morphine Sulfate Administration in Pediatric Subjects
West-Ward Pharmaceutical
NCT03429400
Post-Op Lidocaine Patch
Oregon Health and Science University
NCT03500211
Management of Post-Tonsillectomy Pain in Pediatric Patients
Washington University School of Medicine
NCT04551196
Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.
University of Tennessee
NCT03027661
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 10 |
| Phase 3 | 14 |
| Phase 4 | 36 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Pain, Postoperative Trial Landscape
109 indexed Pain, Postoperative studies · 44 recruiting (40%).
Phase mix: 50 late (III/IV) vs 17 early (I/II).
Top sponsor: Mayo Clinic (5 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Pain, Postoperative?
PlainTrial tracks 109 US clinical trials for Pain, Postoperative, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Pain, Postoperative?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.