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Pain, Postoperative: later-stage trial registry
46 of 114 indexed Pain, Postoperative trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #112 of 28,707 conditions by registered trial count.
114 US clinical trials · 46 currently recruiting · #112 of 28,707 conditions by registered trial count
Pain, Postoperative: 114 US clinical trials tracked, 46 recruiting.
Pain, Postoperative is the subject of 114 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 53 are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most active sponsor is University of Michigan, running 5 of these trials.
Enrollment posture brief
Registry condition pain-postoperative
OPEN 46 | RECR 40% | LATE 53 | EARLY 18 | RANK #112 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Quality of Life (40% recruiting · 109 trials)
Pain, Postoperative lists 46 open slots (40% of 114 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain, Postoperative on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain, Postoperative is recruiting above its size-band peers.
46 of 114 indexed trials (40.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain, Postoperative trials is spread across many organizations.
University of Michigan accounts for 5 of 114 trials (4.4%). 78 distinct sponsors appear on at least one study for this condition label.
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Typical Pain, Postoperative enrolment sits around 80 participants.
Median target enrolment is 80 among the 114 trials that report a genuine target (sentinel values excluded). 67 of those (58.8%) plan for fewer than 100 participants.
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Pain, Postoperative research is mostly interventional.
110 interventional and 4 observational studies make up this index (96.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
114 total, page 2 of 3
Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial
University of Missouri, Kansas City
NCT04680221
Exparel Injection for Postoperative Orbital Pain
Mayo Clinic
NCT02381353
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
Beth Israel Deaconess Medical Center
NCT05283980
A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty
Ohio State University
NCT03498261
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
Campbell Clinic
NCT05099276
Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
University of California, San Francisco
NCT05593237
Blood Ropivacaine Concentrations Following Chest Wall Nerve Block Continuous Infusion
Boston Children's Hospital
NCT02860091
Personalized Prediction of Persistent Postsurgical Pain
Washington University School of Medicine
NCT04864275
Healthcare Provider Behavior and Children's Perioperative Distress
University of California, Irvine
NCT01878747
Evaluation of an Interactive Opioid Risk Education Program (STOMP) for Parents
University of Michigan
NCT03287622
Efficacy and Safety of IV Diclofenac (DIC075V) for Pain After Abdominal or Pelvic Surgery
Javelin Pharmaceuticals
NCT00448110
Evaluate Efficacy and Safety of Extended Release (ER) Naproxen Sodium
Bayer
NCT01389284
Opioid Use After Thyroid and Parathyroid Surgeries
The Methodist Hospital Research Institute
NCT04955444
The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
University of California, San Francisco
NCT03196505
Efficacy of Transversus Abdominis Plane Block Versus Local Injection of Pain Medication
Liberman, Eric, D.O.
NCT02314104
Evaluation of N1539 Following Bunionectomy Surgery
Baudax Bio
NCT02675907
Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery
Xanodyne Pharmaceuticals
NCT00375934
Optimizing Catheter Insertion Technique for Ultrasound-guided Continuous Peripheral Nerve Blocks
VA Palo Alto Health Care System
NCT01459523
Evaluation of Preoperative N1539 in Total Knee Arthroplasty
Baudax Bio
NCT03434275
Expectations and Pain Control Advancement In surgeRy: The REPAIR Trial
University of New Mexi
NCT03726476
Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy Surgery
Baudax Bio
NCT02284243
Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval
Massachusetts General Hospital
NCT03073980
IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty
Hospital for Special Surgery, New York
NCT03020966
Transcutaneous Electrical Nerve Stimulation During Outpatient Endometrial Biopsy
Duke University
NCT05472740
Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure.
Indiana University
NCT03151434
Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy
University of California, Los Angeles
NCT03294109
Mobile Educations Effect on Pain Outcomes
Mayo Clinic
NCT03301610
Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures
Indiana University
NCT03859635
Perioperative Pregabalin in Ureteroscopy
University of Missouri-Columbia
NCT04122196
Intraoperative Liposomal Bupivacaine vs. Bupivacaine for Total Hip Replacement Pain Management
American Hip Institute
NCT03001453
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Cedars-Sinai Medical Center
NCT03723447
Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
Pinnacle Health System
NCT00508976
Preemptive Local Anesthesia in Vaginal Surgery
Mayo Clinic
NCT00318292
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
University of California, Irvine
NCT02086123
Music Therapy in the Treatment of Perioperative Anxiety and Pain
University of Pittsburgh
NCT05263635
Single Shot Liposomal Bupivicaine in Rotator Cuff Surgery
Indiana University
NCT03822182
Liposomal Bupivacaine Versus Interscalene Nerve Block
University of Cincinnati
NCT03929146
Methadone Versus Morphine for Orthopedic Surgery Patients
University of Louisville
NCT00892606
Pudendal Nerve Block in Vaginal Surgery
MetroHealth Medical Center
NCT04198714
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
The Medicines Company
NCT02395653
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
University of Michigan
NCT03577730
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
Children's Hospital of Philadelphia
NCT01394718
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The University of Texas Health Science Center, Houston
NCT04790812
Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty
Kevin King, DO
NCT02453321
BRIDGE Percutaneous Nerve Stimulation for Cesarean Delivery Pain Control
Grace Lim, MD, MS
NCT04365465
Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty
Wake Forest University Health Sciences
NCT02991404
Evaluate the Efficacy and Safety of VVZ-149 Injections for the Treatment of Postoperative Pain Following Bunionectomy
Vivozon
NCT03997812
The Effects of a Music Therapist Designed Listening Program on Intraoperative Vitrectomy
Vanderbilt University Medical Center
NCT03147235
Effect of Cold Therapy Implementation on Multi-modal Postoperative Pain Management
Cleveland Clinic Florida
NCT03129464
Combination Dexamethasone and Bupivacaine Pain Control in Reduction Mammaplasty
Temple University
NCT04919317
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 11 |
| Phase 3 | 15 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain, Postoperative records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain, Postoperative trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain, Postoperative page
114 registered trials, 46 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 46 Pain, Postoperative trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Michigan sponsors the most Pain, Postoperative trials on record, review their full trial history before evaluating a specific study. See University of Michigan's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain, Postoperative condition card totals 114 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.