Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05919745 · ClinicalTrials.gov registry record · Phase 4
Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft
A Phase 4 study of Pain, Postoperative and Quality of Life, sponsored by Marquette University.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT05919745: Recruiting Phase 4 study of Pain, Postoperative and Quality of Life, sponsored by Marquette University.
NCT05919745 is a Phase 4 study of Pain, Postoperative and Quality of Life that is actively recruiting participants, run by Marquette University. The registered enrollment target is 50 participants, below the 273-participant average among 113 other Pain, Postoperative trials with a reported enrollment target (82% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05919745, a Phase 4 study of Pain, Postoperative and Quality of Life, is actively recruiting participants, sponsored by Marquette University.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600mg or placebo by mouth with water 1 hour prior to extraction and bone graft surgery. The primary question it aims to answer is: • Does preemptive ibuprofen have an effect on postoperative pain 1 hour following extraction and bone graft surgery compared to placebo? Secondary questions are: * Does preemptive ibuprofen have an effect on pain during the first 3 postoperative hours and 7 postoperative days following extraction and bone graft surgery compared to placebo? * Does preemptive ibuprofen have an effect on oral health-related quality of life during the 7 postoperative days following extraction and bone graft surgery compared to placebo?
Primary Outcome
Visual Analogue Scale will be used to measure patient-reported pain. Its score range from 0-100 and the higher the score, the worse the reported pain is. Specifically, zero represents no pain and 100 represents the worst pain imaginable.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Ibuprofen 600 mg
- DRUG Acetaminophen
Study Locations (1)
Wisconsin
- Marquette University School of Dentistry Graduate Periodontics Clinic - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2023-10-19 |
| Est. Completion | 2026-12 |
| Phase | Phase 4 |
What NCT05919745 shows while recruiting
NCT05919745 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 273-participant average among 113 other Pain, Postoperative trials with a reported enrollment target (82% lower).
The record links to 2 conditions, with Pain, Postoperative appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT05919745 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05919745 about?
NCT05919745 is a clinical study titled "Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft". The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600...
What is the current status of trial NCT05919745?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 50 participants. The study started on 2023-10-19. Estimated completion is 2026-12.
What conditions does trial NCT05919745 study?
This clinical trial studies the following conditions: Pain, Postoperative, Quality of Life.
What interventions are being tested in trial NCT05919745?
The interventions under investigation include: Placebo (DRUG), Ibuprofen 600 mg (DRUG), Acetaminophen (DRUG).
Who is sponsoring clinical trial NCT05919745?
This trial is sponsored by Marquette University, which has 27 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05919745 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain, Postoperative
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05919745's enrollment target sits among peer trials
50 90th of 113 higher than 20 of 113 other Pain, Postoperative trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Postoperative trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
RECRUITING · Phase 4
-
Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery
RECRUITING · Phase 4
-
The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion
RECRUITING · Phase 4
-
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
RECRUITING · Phase 4
-
IPACK on Early Pain Scores After ACL Reconstruction
RECRUITING · Phase 4
-
Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain
RECRUITING · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00200889 · 50 participants · Early Phase 1
Mapping Auricular Vagus Nerve Circuitry
- NCT00409435 · 50 participants · Phase 2
A Study of Pyridostigmine in Postural Tachycardia Syndrome
- NCT01202305 · 50 participants
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
- NCT01225913 · 50 participants · Phase 4
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI