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2026 data Public-data reference. official source

Diffuse Large B Cell Lymphoma

Open-data reference.

48 US clinical trials · 26 currently recruiting

Active & Recent Trials

RECRUITING 7,000 participants

A Non-interventional, International, Multicentre Clinical Research Study to Build the Largest Collection of Multimodal Data (Including Clinical Data, Imaging Data and Omics Data) in Oncology

OWKIN

NCT06625203

RECRUITING Phase 1 614 participants

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

BeOne Medicines

NCT05006716

RECRUITING 500 participants

Long-term Follow-up Study of Patients Receiving CAR-T Cells

Medical College of Wisconsin

NCT03375619

RECRUITING Phase 1 317 participants

A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma

AstraZeneca

NCT04594642

RECRUITING 300 participants

Optimizing ctDNA-based MRD Assessment in DLBCL, MCL, and FL Patients Undergoing CAR Therapy

Adaptive Biotechnologies

NCT05255354

RECRUITING Phase 1 275 participants

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

Novartis Pharmaceuticals

NCT04104776

RECRUITING Phase 1 168 participants

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

OncoNano Medicine

NCT06022029

RECRUITING Phase 1 140 participants

IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas

Iksuda Therapeutics

NCT05365659

RECRUITING Phase 1 100 participants

CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

Medical College of Wisconsin

NCT04186520

RECRUITING Phase 1 60 participants

Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

Newave Pharmaceutical

NCT04775745

RECRUITING Phase 2 50 participants

A Study of Circulating Tumor DNA (ctDNA) Testing for People With B-Cell Lymphoma

Memorial Sloan Kettering Cancer Center

NCT06736613

RECRUITING NA 40 participants

ctDNA-guided Therapy Optimization in Newly Diagnosed DLBCL

Hua-Jay J Cherng, MD

NCT06693830

RECRUITING Phase 1 38 participants

Tazemetostat and Venetoclax in Relapsed/Refractory Non-Hodgkin Lymphoma

Weill Medical College of Cornell University

NCT05618366

RECRUITING Phase 2 36 participants

CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based Autologous Stem Cell Transplant

Washington University School of Medicine

NCT06687772

RECRUITING Phase 1 36 participants

Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

C. Babis Andreadis

NCT04545762

RECRUITING Phase 1 32 participants

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Vironexis Biotherapeutics

NCT06533579

RECRUITING Phase 1 30 participants

Study of IOMAB-ACT Followed by CAR-T Cell Therapy for Patients Relapsed or Refractory (Diffuse Large B-cell Lymphoma

University of Texas Southwestern Medical Center

NCT06768905

RECRUITING Phase 2 30 participants

Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

John Lister

NCT05281809

RECRUITING Phase 2 28 participants

Emapalumab Prevention of CAR-T Cell Associated Toxicities

Marcela V. Maus, M.D.,Ph.D.

NCT06550141

RECRUITING Phase 2 27 participants

Itacitinib Pre-modulation in DLBCL Receiving CAR T Cell Therapy

H. Lee Moffitt Cancer Center and Research Institute

NCT05757219

RECRUITING Phase 1 24 participants

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

Marcela V. Maus, M.D.,Ph.D.

NCT06026319

RECRUITING Phase 1 20 participants

Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies

Joshua Sasine, MD, PhD

NCT05887167

RECRUITING Phase 1 15 participants

A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas

Weill Medical College of Cornell University

NCT05934838

RECRUITING Phase 1 15 participants

Mosunetuzumab Consolidation Therapy After autoSCT in r/r Aggressive B Cell Lymphoma

Washington University School of Medicine

NCT05412290

RECRUITING Phase 1 12 participants

LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies

Medical College of Wisconsin

NCT05990465

RECRUITING Phase 1 10 participants

Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies

University of Utah

NCT06227026

ACTIVE NOT RECRUITING NA 241 participants

Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma

Duke University

NCT03681535

ACTIVE NOT RECRUITING Phase 1 190 participants

A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

NCT03162536

ACTIVE NOT RECRUITING Phase 2 120 participants

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

Cellectar Biosciences

NCT02952508

ACTIVE NOT RECRUITING Phase 1 67 participants

Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas

Immunitas Therapeutics

NCT05565417

ACTIVE NOT RECRUITING Phase 1 53 participants

Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients

Incyte Corporation

NCT05222555

ACTIVE NOT RECRUITING Phase 2 51 participants

Pembrolizumab in Combination With Chemotherapy for Patients With Untreated B Cell Lymphoma

University of Chicago

NCT03995147

ACTIVE NOT RECRUITING Phase 1 48 participants

Copanlisib Plus Venetoclax in R/R DLBCL

Dana-Farber Cancer Institute

NCT04572763

ACTIVE NOT RECRUITING Phase 1 43 participants

Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

University of Michigan Rogel Cancer Center

NCT03842696

ACTIVE NOT RECRUITING Phase 1 36 participants

Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignancies

Synthekine

NCT05665062

ACTIVE NOT RECRUITING Phase 1 30 participants

19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers

Memorial Sloan Kettering Cancer Center

NCT04464200

ACTIVE NOT RECRUITING Phase 2 27 participants

Split-Dose R-CHOP for Older Adults With DLBCL

University of Wisconsin, Madison

NCT03943901

ACTIVE NOT RECRUITING Phase 1 21 participants

Phase 1 Study of Autologous CD30.CAR-T in Relapsed or Refractory CD30 Positive Non-Hodgkin Lymphoma

Tessa Therapeutics

NCT04526834

ACTIVE NOT RECRUITING Phase 1 18 participants

Tumor Associated Antigen Specific T Cells (TAA-T) With PD1 Inhibitor for Lymphoma

Catherine Bollard

NCT03843294

COMPLETED Phase 2 82 participants

Pembrolizumab After ASCT for Hodgkin Lymphoma, DLBCL and T-NHL

Dana-Farber Cancer Institute

NCT02362997

COMPLETED NA 46 participants

Use of a Patient Preferences Shared Decision-Making Encounter Tool in Clinical Practice for Patients With DLBCL and FL

Carevive Systems

NCT04160442

COMPLETED Phase 1 39 participants

Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

Masonic Cancer Center, University of Minnesota

NCT03019666

COMPLETED Phase 1 26 participants

BR101801 in Adult Patients With Advanced Hematologic Malignancies(Phase I)

Boryung Pharmaceutical Co.

NCT04018248

COMPLETED Phase 2 22 participants

Imexon for Relapsed Follicular and Aggressive Lymphomas

University of Rochester

NCT01314014

COMPLETED Early Phase 1 15 participants

Molecular Monitoring With Circulating Tumor DNA and Nivolumab Maintenance

Fox Chase Cancer Center

NCT03311958

COMPLETED NA 10 participants

Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)

Massachusetts General Hospital

NCT06004167

COMPLETED Phase 1 7 participants

Safety, PK/PD, and Clinical Activity of KT-413 in Adult Patients with Relapsed or Refractory B-cell NHL

Kymera Therapeutics

NCT05233033

COMPLETED Phase 1 6 participants

TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia

TCR2 Therapeutics

NCT04323657

Reading the Diffuse Large B Cell Lymphoma Trial Landscape

ClinicalTrials.gov lists 48 US studies indexed under Diffuse Large B Cell Lymphoma, and 26 of those are currently open to recruitment — roughly 54% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Diffuse Large B Cell Lymphoma shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 41 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Diffuse Large B Cell Lymphoma is led by Medical College of Wisconsin with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 48 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diffuse Large B Cell Lymphoma?

PlainTrial tracks 48 US clinical trials for Diffuse Large B Cell Lymphoma, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diffuse Large B Cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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