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NCT05991453 · ClinicalTrials.gov registry record · NA
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
A NA study of Surgery and Pain, Postoperative, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- NA
- Development phase
- 13,000
- Enrollment target
- 20
- Study locations
NCT05991453: Recruiting NA study of Surgery and Pain, Postoperative, sponsored by Washington University School of Medicine.
NCT05991453 is a NA study of Surgery and Pain, Postoperative that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 13,000 participants, below the 52,743-participant average among 120 other Surgery trials with a reported enrollment target (75% lower). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05991453, a NA study of Surgery and Pain, Postoperative, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- NA
- Development phase
- 13,000 participants
- Enrollment target
- 20
- Study locations
Study Summary
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Primary Outcome
The QOR15 instrument measures quality of recovery with a score of 0 - 150 points where the higher the score the better quality of recovery.
Conditions Studied
Interventions
- OTHER Anesthetic technique Propofol TIVA
- OTHER Anesthetic technique inhaled agent
Study Locations (20)
California
- University of California San Francisco - San Francisco
- Stanford University - Stanford
Massachusetts
- Massachusetts General Hospital - Boston
- Brigham & Women's - Boston
Michigan
- University of Michigan - Ann Arbor
- Henry Ford Health - Detroit
New York
- NYU Langone - New York
- Weill Cornell Medicine - New York
North Carolina
- Duke University - Durham
- Wake Forest - Winston-Salem
Arkansas
- University of Arkansas for Medical Sciences (UAMS) - Little Rock
Connecticut
- Yale School of Medicine - New Haven
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13,000 participants |
| Start Date | 2023-09-13 |
| Est. Completion | 2028-07-31 |
| Phase | NA |
What NCT05991453 shows while recruiting
NCT05991453 is an interventional study that assigns participants to a tested intervention. Its 13,000 participants enrollment target places it among the larger protocols in the corpus, below the 52,743-participant average among 120 other Surgery trials with a reported enrollment target (75% lower).
The record links to 8 conditions, with Surgery appearing as the primary indexed condition, and to 2 interventions - of which Anesthetic technique Propofol TIVA is the first listed.
NCT05991453 names 20 study sites across 15 states, led by California, Massachusetts, Michigan.
Frequently Asked Questions
What is clinical trial NCT05991453 about?
NCT05991453 is a clinical study titled "Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial". The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (i...
What is the current status of trial NCT05991453?
This trial is currently recruiting. It is a NA study. The enrollment target is 13,000 participants. The study started on 2023-09-13. Estimated completion is 2028-07-31.
What conditions does trial NCT05991453 study?
This clinical trial studies the following conditions: Surgery, Pain, Postoperative, Quality of Life, Anesthesia, Surgery--Complications.
What interventions are being tested in trial NCT05991453?
The interventions under investigation include: Anesthetic technique Propofol TIVA (OTHER), Anesthetic technique inhaled agent (OTHER).
Who is sponsoring clinical trial NCT05991453?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05991453 being conducted?
This trial has 20 study locations across Arkansas, California, Connecticut, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Surgery
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05991453's enrollment target sits among peer trials
13,000 5th of 120 higher than 116 of 120 other Surgery trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Surgery trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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