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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
NCT05991453 · View on ClinicalTrials.gov ↗
Study Summary
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Conditions Studied
Interventions
- OTHER Anesthetic technique Propofol TIVA
- OTHER Anesthetic technique inhaled agent
Study Locations (20)
California
- University of California San Francisco — San Francisco
- Stanford University — Stanford
Massachusetts
- Massachusetts General Hospital — Boston
- Brigham & Women's — Boston
Michigan
- University of Michigan — Ann Arbor
- Henry Ford Health — Detroit
New York
- NYU Langone — New York
- Weill Cornell Medicine — New York
North Carolina
- Duke University — Durham
- Wake Forest — Winston-Salem
Arkansas
- University of Arkansas for Medical Sciences (UAMS) — Little Rock
Connecticut
- Yale School of Medicine — New Haven
Missouri
- Washington University School of Medicine — St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13,000 participants |
| Start Date | 2023-09-13 |
| Est. Completion | 2028-07-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05991453
The ClinicalTrials.gov registry entry for NCT05991453 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 13,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,036 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 8 conditions, with Surgery appearing as the primary indexed condition, and to 2 interventions — of which Anesthetic technique Propofol TIVA is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05991453 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Massachusetts, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05991453 about?
NCT05991453 is a clinical study titled "Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial". The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (i...
What is the current status of trial NCT05991453?
This trial is currently recruiting. It is a NA study. The enrollment target is 13,000 participants. The study started on 2023-09-13. Estimated completion is 2028-07-31.
What conditions does trial NCT05991453 study?
This clinical trial studies the following conditions: Surgery, Quality of Life, Pain, Postoperative, Anesthesia, Anesthesia Complication. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05991453?
The interventions under investigation include: Anesthetic technique Propofol TIVA (OTHER), Anesthetic technique inhaled agent (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05991453?
This trial is sponsored by Washington University School of Medicine, which has 1,036 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05991453 being conducted?
This trial has 20 study locations across Arkansas, California, Connecticut, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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