Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Quality of Life

Open-data reference.

109 US clinical trials · 44 currently recruiting

Active & Recent Trials

RECRUITING NA 13,000 participants

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

Washington University School of Medicine

NCT05991453

RECRUITING 10,000 participants

The Lake Nona Life Project

University of Central Florida

NCT02533804

RECRUITING NA 2,600 participants

Embedded Palliative Care in the MICU

Washington University School of Medicine

NCT06574672

RECRUITING NA 1,800 participants

M2VA Pain Care Pathway

Yale University

NCT06526143

RECRUITING 1,218 participants

Quality of Life and Life Satisfaction in Pediatric and Adolescent Gymnasts Through Injury

University of Colorado, Denver

NCT05110729

RECRUITING 1,200 participants

A Cardiac Disease Quality of Life Study

The Cleveland Clinic

NCT04080492

RECRUITING 1,000 participants

International CIPN Assessment and Validation Study

University of Milano Bicocca

NCT04633655

RECRUITING NA 1,000 participants

Improving Congenital Heart Disease Care

University of California, San Francis

NCT06581484

RECRUITING NA 668 participants

Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

VA Office of Research and Development

NCT04179981

RECRUITING NA 480 participants

Together After Cancer

University of South Florida

NCT05645471

RECRUITING NA 450 participants

CAPABLE Care + Connect

Johns Hopkins University

NCT07123298

RECRUITING NA 400 participants

Project HOPEFUL: A PN-RCT With Implementation Science

University of Florida

NCT07475039

RECRUITING NA 348 participants

Improving Behavioral Health for Caregivers and Children After Pediatric Injury

Medical University of South Carolina

NCT06856057

RECRUITING NA 334 participants

Mobile Health Program for Rural Hypertension

University of Pittsburgh

NCT05546931

RECRUITING 300 participants

Expanded Population Health Model Evaluation

Baylor Research Institute

NCT06044831

RECRUITING NA 208 participants

OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)

Case Western Reserve University

NCT05293756

RECRUITING NA 160 participants

The Student Wellness and Emotional Growth Resiliency (SWAG-R) Program

Nova Southeastern University

NCT06652503

RECRUITING NA 150 participants

Breast Cancer - Navigate - Prospective Cohort

Northwestern University

NCT06271356

RECRUITING NA 120 participants

Mindfulness in Endometrial and Cervical Cancer

St. Louis University

NCT04512144

RECRUITING NA 120 participants

Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)

Baylor College of Medicine

NCT05752448

RECRUITING NA 120 participants

Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life

Yale University

NCT05810259

RECRUITING NA 114 participants

Effect of a Fermented Dairy Protein With Prebiotic Fiber on GI Complaints

Arizona State University

NCT06946017

RECRUITING NA 110 participants

Improving Exercise Capacity With a Tailored Physical Activity Intervention

Wake Forest University Health Sciences

NCT05595577

RECRUITING NA 100 participants

Therapeutic Plantar Electrical Stimulation Intervention During Hemodialysis to Improve Balance and Mobility

Hamad Medical Corporation

NCT05407207

RECRUITING NA 100 participants

Effect of Drain Care on Infection Rate and Quality of Life in Implant-Based Breast Reconstruction.

University of Missouri-Columbia

NCT05846438

RECRUITING NA 91 participants

Effects of Assisted Robotic vs Laparoscopic Sleeve Gastrectomy

Ricard Corcelles

NCT06425016

RECRUITING Phase 2 90 participants

Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy

UNC Lineberger Comprehensive Cancer Center

NCT05472792

RECRUITING NA 90 participants

PODER Familiar: Health Promotion for Latino Families of Children With IDD

University of Texas at Austin

NCT05713617

RECRUITING NA 80 participants

Asthma Intervention With Residential Ventilation and Air Cleaner (AIRVAC) Study

The University of Texas at Arlington

NCT07196436

RECRUITING NA 75 participants

Developing a Smartphone Application to Support Veteran Opioid Use Disorder Treatment

VA Office of Research and Development

NCT06454903

RECRUITING NA 60 participants

The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors

Arizona State University

NCT06938555

RECRUITING 60 participants

Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor

Vanderbilt University Medical Center

NCT01734122

RECRUITING NA 60 participants

Telehealth to Improve Quality of Life in Persons Living in Rural Texas

Texas Tech University

NCT07119710

RECRUITING Phase 4 50 participants

Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft

Marquette University

NCT05919745

RECRUITING NA 50 participants

A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI

Central Arkansas Veterans Healthcare System

NCT06024473

RECRUITING NA 48 participants

The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project

Massachusetts General Hospital

NCT07221422

RECRUITING NA 43 participants

CAPABLE Transplant

Johns Hopkins University

NCT06326905

RECRUITING NA 42 participants

Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques

The University of Texas Medical Branch, Galveston

NCT07112404

RECRUITING NA 40 participants

Exploring Virtual Reality Adventure Training Exergaming

The University of Texas at Arlington

NCT05563805

RECRUITING NA 36 participants

Development of a Multi-sensory Rehabilitation Program for People With Ultra Low Vision

State University of New York College of Optometry

NCT05028712

RECRUITING NA 25 participants

Quality of Life in Pediatric Patients With Acute Lymphoblastic Leukemia Receiving Maintenance Chemotherapy

Connecticut Children's Medical Center

NCT03132948

RECRUITING NA 15 participants

Effects of an Exercise Program on Reaction Time and Mouse Accuracy in Recreational Video Game Players

University of Miami

NCT06512675

RECRUITING NA 12 participants

Climbing Lifestyle Intervention for Modifying Physical Activity Behaviors: Pilot Study

Northern Michigan University

NCT06368128

RECRUITING NA 10 participants

Standardized Yoga & Meditation Program for Stress Reduction for Adolescents With Irritable Bowel Syndrome

The Cooper Health System

NCT05719246

ACTIVE NOT RECRUITING NA 400 participants

Clinic-Based Financial Coaching and Family Health and Development

University of California, Los Angeles

NCT03736590

ACTIVE NOT RECRUITING Phase 2 336 participants

Efficacy of a Self-advocacy Serious Game Intervention

University of Pittsburgh

NCT04813276

ACTIVE NOT RECRUITING NA 314 participants

Peer Approaches to Lupus Self-management

Medical University of South Carolina

NCT03734055

ACTIVE NOT RECRUITING NA 260 participants

Roadmap to Parenthood: Testing the Efficacy of a Decision Aid and Planning Tool for Family Building After Cancer

Stanford University

NCT06050135

ACTIVE NOT RECRUITING NA 250 participants

Guaranteed Income and Financial Treatment

Meredith Doherty, PhD, LCSW

NCT06611982

ACTIVE NOT RECRUITING NA 204 participants

Ostomy Rural Telehealth Training Cancer Survivors

Abramson Cancer Center at Penn Medicine

NCT03913715

ACTIVE NOT RECRUITING NA 200 participants

Invest-CTO PCI Trial

Haukeland University Hospital

NCT04774913

ACTIVE NOT RECRUITING 176 participants

Long Term Follow up of Children Enrolled in the REDvent Study

Children's Hospital Los Angeles

NCT03709199

ACTIVE NOT RECRUITING NA 80 participants

Multidisciplinary Intervention In Chronic GVHD

Massachusetts General Hospital

NCT04479995

ACTIVE NOT RECRUITING NA 41 participants

Digital Symptom Tracking, Patient Engagement and Quality of Life in Advanced Cancer

Stanford University

NCT05112198

ACTIVE NOT RECRUITING NA 40 participants

Bright IDEAS for Pediatric Palliative Care: A Problem-Solving Skills Intervention to Empower Parent Resilience

Children's Hospital Los Angeles

NCT05899998

ACTIVE NOT RECRUITING NA 30 participants

Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure

University of Pittsburgh

NCT06576297

ACTIVE NOT RECRUITING NA 20 participants

Horizons Chronic Graft-Versus-Host-Disease Study

University of Miami

NCT06160986

ACTIVE NOT RECRUITING NA 20 participants

Digital Health Intervention to Promote Quality of Life in Adults With Chronic Graft Versus Host Disease

University of Miami

NCT06688942

ACTIVE NOT RECRUITING NA 20 participants

Digital Literacy Intervention to Address Support, Literacy and Communication in Older Adults

Johns Hopkins University

NCT06479707

ACTIVE NOT RECRUITING NA 5 participants

Impact of Different Carbohydrate Feedings on a Hydrogen Breath Curve and Self-reported Gastrointestinal Complaints

Arizona State University

NCT06648967

COMPLETED NA 3,063 participants

Safety and Feasibility of Polychromatic Light Emitting Diode for Peripheral Catheter Illumination During Peripheral Intravenous Delivery of Normal Saline

UVLrx Therapeutics

NCT02785133

COMPLETED NA 671 participants

The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT)

University of Florida

NCT07204444

COMPLETED NA 445 participants

Symptom Screening Linked to Care Pathways

The Hospital for Sick Children

NCT04614662

COMPLETED NA 392 participants

Impact of Teledermatology on Health Services Outcomes in the Department of Veterans Affairs

US Department of Veterans Affairs

NCT00488293

COMPLETED NA 373 participants

Implementation of Multidisciplinary Assessments for Geriatric Patients in an ED Observation Unit

Ohio State University

NCT04068311

COMPLETED NA 327 participants

A Trial of an Integrated Clinic-community Intervention in Children and Adolescents With Obesity (Hearts and Parks)

Duke University

NCT03339440

COMPLETED NA 307 participants

Multilevel Intervention for Physical Activity in Retirement Communities

University of California, San Diego

NCT01155011

COMPLETED NA 300 participants

Comprehensive Care of Children With Medical Complexity

Seton Healthcare Family

NCT01834456

COMPLETED Phase 2 265 participants

Sunshine 2 Study for Women With Diabetes

Loyola University

NCT01904032

COMPLETED NA 263 participants

Prostate Cancer: Family Care for Patients and Spouses

University of Michigan

NCT00708968

COMPLETED 216 participants

Quality of Life and Pain Outcomes Following Video-Assisted Thoracic Surgery (VATS) Anatomic Lung Resection Versus Thoracotomy and Anatomic Lung Resection

Memorial Sloan Kettering Cancer Center

NCT00598000

COMPLETED 208 participants

The In4M Study: Integrating 4 Methods to Assess Physical Function in Cancer Patients

Yale University

NCT05214144

COMPLETED NA 202 participants

Active Recreation Through Community-Healthcare Engagement Study

Duke University

NCT03246763

COMPLETED NA 186 participants

Technology and Family Thriving Study

University of California, Santa Barbara

NCT05150990

COMPLETED NA 124 participants

Blue Star Cares: Innovative Approaches to Helping Military-Connected Caregivers

University of Southern California

NCT03336190

COMPLETED NA 111 participants

FitEx for Endometrial Cancer Survivors: Initial Efficacy

Carilion Clinic

NCT05737745

COMPLETED NA 110 participants

An Exploratory Investigation of Dietary Supplementation and Its Effect

HUM Nutrition

NCT05037877

COMPLETED NA 104 participants

The PediQUEST Study: Evaluation of Pediatric Quality of Life and Evaluation of Symptoms Technology

Dana-Farber Cancer Institute

NCT01838564

COMPLETED NA 98 participants

Protein-Prebiotic Wellbeing Study

Arizona State University

NCT05303753

COMPLETED NA 75 participants

The "PC-LIGHT" Study

Northwestern University

NCT03419585

COMPLETED NA 74 participants

CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners

Johns Hopkins University

NCT05187117

COMPLETED NA 68 participants

Stepped-Care Telehealth for Distress in Cancer Survivors

Wake Forest University Health Sciences

NCT03060096

COMPLETED NA 64 participants

Effects of Arts Engagement on Physical Performance, Cognition, Social Isolation, and Self-Perception in Older Adults

George Mason University

NCT04281654

COMPLETED NA 60 participants

Improving Supportive Care For Patients With Thoracic Malignancies

Palo Alto Veterans Institute for Research

NCT03216109

COMPLETED NA 54 participants

Treating Cancer-Related Fatigue Through Systematic Light Exposure

Icahn School of Medicine at Mount Sinai

NCT01873794

COMPLETED NA 54 participants

Effects of a Proactive Social Robot for Older Adults in Reducing Loneliness and Social Isolation

Baycrest

NCT03972787

COMPLETED NA 53 participants

Internet and Telephone Support Intervention for Stroke Caregivers

VA Office of Research and Development

NCT04348851

COMPLETED NA 53 participants

Mindful Kala: Virtual Bharatanatyam Wellness Program for Students

Yale University

NCT04745364

COMPLETED NA 50 participants

Focused Palliative Care Intervention in Advanced Heart Failure

Brigham and Women's Hospital

NCT02805712

COMPLETED Phase 4 50 participants

Pediatric Dysphagia Outcomes After Injection Laryngoplasty for Type I Laryngeal Cleft

Oregon Health and Science University

NCT01507207

COMPLETED NA 49 participants

Physical Therapy on Quality of Life and Function Following Vaginal Surgery Reconstructive Surgery

TriHealth

NCT01403701

COMPLETED NA 48 participants

Neuromodulation of Central Sensory Integration to Improve Postural Control

University of Pittsburgh

NCT06610617

COMPLETED NA 46 participants

Computerized Cognitive Training in Breast Cancer Survivors

Ohio State University

NCT05570604

COMPLETED NA 45 participants

Effects of a Community Based Exercise Program in Adults With Severe Burns

The University of Texas Medical Branch, Galveston

NCT01184547

COMPLETED 44 participants

Laser Ablation After Stereotactic Radiosurgery

Monteris Medical

NCT01651078

COMPLETED 36 participants

Long-Term Effects of Iodine I Tositumomab and Autologous Bone Marrow or Stem Cell Transplantation in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Fred Hutchinson Cancer Center

NCT00098566

COMPLETED NA 36 participants

Effectiveness of 10-minute Chair Massage Versus 10-minute Break to Reduce Stress and Improve Well-being

Geisinger Clinic

NCT04787107

COMPLETED NA 33 participants

Intervention Development and Evaluation to Reduce Disparities in Quality of Life for Latino Families Impacted by Cancer

University of California, Irvine

NCT06622252

COMPLETED NA 30 participants

High-Speed Yoga and Executive Function

University of Miami

NCT04215900

COMPLETED NA 30 participants

Improving Care of Patients With Heart Failure

University of California, San Francis

NCT01461681

Phase Distribution

PhaseTrial count
Early Phase 1 1
Phase 2 3
Phase 3 1
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Quality of Life Trial Landscape

ClinicalTrials.gov lists 109 US studies indexed under Quality of Life, and 44 of those are currently open to recruitment — roughly 40% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Quality of Life shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Quality of Life is led by Arizona State University with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Quality of Life?

PlainTrial tracks 109 US clinical trials for Quality of Life, of which 44 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Quality of Life?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →