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Type 1 Diabetes Mellitus clinical trials
23 of 106 indexed Type 1 Diabetes Mellitus trials are currently recruiting.
106 US clinical trials · 23 currently recruiting
Type 1 Diabetes Mellitus is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 23 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 35 in Phase 1-2 (earlier-stage). The most active sponsor is University of Virginia, running 8 of these trials.
The research picture
Type 1 Diabetes Mellitus has 106 registered US clinical trials, 23 of them open to new participants right now, about 22% of the total.
- 23
- recruiting participants now
- 22%
- of trials open to enrollment
- 19
- in Phase 3–4 (later-stage)
- 8
- top sponsor: University of Virginia
Active & Recent Trials
106 total, page 1 of 3
Twiist Postmarket Surveillance Study for Type 1 Diabetes
Deka Research and Development
NCT07356089
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
Sanofi
NCT07088068
GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes
Medtronic Diabetes
NCT07228117
A Hybrid Effectiveness-implementation Trial to Reduce Diabetes Distress in Teenagers
Ann & Robert H Lurie Children's Hospital of Chicago
NCT06709755
FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)
Sanofi
NCT06111586
Dapagliflozin Plus Pioglitazone in T1DM
The University of Texas Health Science Center at San Antonio
NCT03878459
Type 1 Diabetes Extension Study
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02734277
INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes
Mannkind Corporation
NCT07224321
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
COUR Pharmaceutical Development Company
NCT06783309
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
University of Chicago
NCT06305286
The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System
Joslin Diabetes Center
NCT05754281
The Effects of Fluoxetine and/or DHEA
University of Maryland, Baltimore
NCT03228732
Implementing the Spotlight AQ Platform in Adolescent/ Young Adult (16-25 Years Old) Type 1 Diabetics (T1D)
Children's Mercy Hospital Kansas City
NCT06390371
Long Term Surveillance of Islet Transplant Recipients Following Complete Graft Loss
Rodolfo Alejandro
NCT02000687
Accuracy and Precision of the Continuous Glucose Monitoring System 'CareSens Air 3' in Adult Patients With T1DM
i-SENS
NCT07296276
Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.
Estar Medical dba Medical Technologies
NCT06810726
Long Term Follow up of Recipients of Functional Islet Allografts
Rodolfo Alejandro
NCT01999374
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
Vanderbilt University Medical Center
NCT06609356
Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes
Stanford University
NCT07090824
PACTAID App in Adults With Type 1 Diabetes to Help Manage Exercise
Mayo Clinic
NCT06730906
Prevention of de Novo Allosensitization in Islet Transplant Recipients Following Complete Graft Loss
Rodolfo Alejandro
NCT01999361
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
GentiBio
NCT06919354
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory
NCT06575426
Home Video-based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children
Nemours Children's Clinic
NCT03914547
A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes
Diamyd Medical AB
NCT05018585
Safety and Effectiveness of the Luna System in People With Type 1 Diabetes Mellitus
Luna Diabetes
NCT06627517
Treatment of Type 1 Diabetes With Anti-OX40L Bispecific With Anti-TNF Activity In a Single Nanobody® Molecule
Sanofi
NCT06812988
Triple Therapy in T1DM
State University of New York at Buffalo
NCT03899402
Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03929601
Reducing Innate Inflammation in New Onset Type 1 Diabetes
Medical College of Wisconsin
NCT04335656
Probiotics in Newly Diagnosed T1D
Medical College of Wisconsin
NCT04141761
Impact of Metabolic Health on Sperm Epigenetic Marks in Humans
Joslin Diabetes Center
NCT03860558
Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol
CellTrans
NCT00679042
A Safety, Tolerability and Efficacy Study of Sernova's Cell Pouch™ for Clinical Islet Transplantation
Sernova Biotherapeutics
NCT03513939
Islet Cell Transplant for Type 1 Diabetes
City of Hope Medical Center
NCT01909245
An Immunotherapy Vaccine (PIpepTolDC) for the Treatment of Patients With Type 1 Diabetes
City of Hope Medical Center
NCT04590872
A Study of LY900014 in Participants With Type 1 Diabetes
Eli Lilly and Company
NCT03214367
An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes
AstraZeneca
NCT00229658
The Protégé Study - Clinical Trial of MGA031 in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus
MacroGenics
NCT00385697
Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 1 Diabetes Mellitus
Sanofi
NCT01683266
Clinical Trial Evaluating Technosphere® Insulin Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Over a 24-week Treatment Period
Mannkind Corporation
NCT01445951
CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM)
Halozyme Therapeutics
NCT01848990
Positive Psychology Intervention to Treat Diabetes Distress in Teens With Type 1 Diabetes
Vanderbilt University Medical Center
NCT03845465
Recent-Onset Type 1 Diabetes Trial Evaluating Efficacy and Safety of Teplizumab
Provention Bio
NCT03875729
Evaluation of Updated Continuous Glucose Monitoring (CGM) Form Factor in Adults, Adolescents and Pediatrics
Medtronic Diabetes
NCT04436822
A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes
Bayer
NCT05901831
Technological Advances in Glucose Management in Older Adults
Joslin Diabetes Center
NCT03078491
Shared Medical Decision Making in Pediatric Diabetes
Nemours Children's Clinic
NCT02496156
Effectiveness Trial of an E-Health Intervention To Support Diabetes Care in Minority Youth (3Ms)
Wayne State University
NCT03168867
Tocilizumab (TCZ) in New-onset Type 1 Diabetes
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02293837
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 16 |
| Phase 3 | 14 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 1 Diabetes Mellitus Trial Landscape
106 indexed Type 1 Diabetes Mellitus studies · 23 recruiting (22%).
Phase mix: 19 late (III/IV) vs 35 early (I/II).
Top sponsor: University of Virginia (8 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 1 Diabetes Mellitus?
PlainTrial tracks 106 US clinical trials for Type 1 Diabetes Mellitus, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 1 Diabetes Mellitus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.