Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Type 1 Diabetes Mellitus
Open-data reference.
106 US clinical trials · 23 currently recruiting
Active & Recent Trials
Twiist Postmarket Surveillance Study for Type 1 Diabetes
Deka Research and Development
NCT07356089
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
Sanofi
NCT07088068
GATEWAY: Safety Evaluation of the MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes
Medtronic Diabetes
NCT07228117
A Hybrid Effectiveness-implementation Trial to Reduce Diabetes Distress in Teenagers
Ann & Robert H Lurie Children's Hospital of Chicago
NCT06709755
FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)
Sanofi
NCT06111586
Dapagliflozin Plus Pioglitazone in T1DM
The University of Texas Health Science Center at San Antonio
NCT03878459
Type 1 Diabetes Extension Study
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02734277
INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes
Mannkind Corporation
NCT07224321
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
COUR Pharmaceutical Development Company
NCT06783309
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
University of Chicago
NCT06305286
The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System
Joslin Diabetes Center
NCT05754281
The Effects of Fluoxetine and/or DHEA
University of Maryland, Baltimore
NCT03228732
Implementing the Spotlight AQ Platform in Adolescent/ Young Adult (16-25 Years Old) Type 1 Diabetics (T1D)
Children's Mercy Hospital Kansas City
NCT06390371
Long Term Surveillance of Islet Transplant Recipients Following Complete Graft Loss
Rodolfo Alejandro
NCT02000687
Accuracy and Precision of the Continuous Glucose Monitoring System 'CareSens Air 3' in Adult Patients With T1DM
i-SENS
NCT07296276
Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.
Estar Medical dba Medical Technologies
NCT06810726
Long Term Follow up of Recipients of Functional Islet Allografts
Rodolfo Alejandro
NCT01999374
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
Vanderbilt University Medical Center
NCT06609356
Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes
Stanford University
NCT07090824
PACTAID App in Adults With Type 1 Diabetes to Help Manage Exercise
Mayo Clinic
NCT06730906
Prevention of de Novo Allosensitization in Islet Transplant Recipients Following Complete Graft Loss
Rodolfo Alejandro
NCT01999361
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
GentiBio
NCT06919354
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory
NCT06575426
Home Video-based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children
Nemours Children's Clinic
NCT03914547
A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes
Diamyd Medical AB
NCT05018585
Safety and Effectiveness of the Luna System in People With Type 1 Diabetes Mellitus
Luna Diabetes
NCT06627517
Treatment of Type 1 Diabetes With Anti-OX40L Bispecific With Anti-TNF Activity In a Single Nanobody® Molecule
Sanofi
NCT06812988
Triple Therapy in T1DM
State University of New York at Buffalo
NCT03899402
Rituximab-pvvr and Abatacept vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03929601
Reducing Innate Inflammation in New Onset Type 1 Diabetes
Medical College of Wisconsin
NCT04335656
Probiotics in Newly Diagnosed T1D
Medical College of Wisconsin
NCT04141761
Impact of Metabolic Health on Sperm Epigenetic Marks in Humans
Joslin Diabetes Center
NCT03860558
Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol
CellTrans
NCT00679042
A Safety, Tolerability and Efficacy Study of Sernova's Cell Pouch™ for Clinical Islet Transplantation
Sernova Biotherapeutics
NCT03513939
Islet Cell Transplant for Type 1 Diabetes
City of Hope Medical Center
NCT01909245
An Immunotherapy Vaccine (PIpepTolDC) for the Treatment of Patients With Type 1 Diabetes
City of Hope Medical Center
NCT04590872
A Study of LY900014 in Participants With Type 1 Diabetes
Eli Lilly and Company
NCT03214367
An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes
AstraZeneca
NCT00229658
The Protégé Study - Clinical Trial of MGA031 in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus
MacroGenics
NCT00385697
Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 1 Diabetes Mellitus
Sanofi
NCT01683266
Clinical Trial Evaluating Technosphere® Insulin Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Over a 24-week Treatment Period
Mannkind Corporation
NCT01445951
CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM)
Halozyme Therapeutics
NCT01848990
Positive Psychology Intervention to Treat Diabetes Distress in Teens With Type 1 Diabetes
Vanderbilt University Medical Center
NCT03845465
Recent-Onset Type 1 Diabetes Trial Evaluating Efficacy and Safety of Teplizumab
Provention Bio
NCT03875729
Evaluation of Updated Continuous Glucose Monitoring (CGM) Form Factor in Adults, Adolescents and Pediatrics
Medtronic Diabetes
NCT04436822
A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes
Bayer
NCT05901831
Technological Advances in Glucose Management in Older Adults
Joslin Diabetes Center
NCT03078491
Shared Medical Decision Making in Pediatric Diabetes
Nemours Children's Clinic
NCT02496156
Effectiveness Trial of an E-Health Intervention To Support Diabetes Care in Minority Youth (3Ms)
Wayne State University
NCT03168867
Tocilizumab (TCZ) in New-onset Type 1 Diabetes
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02293837
CloudConnect: Predictive And Retrospective Clinical Decision Support For Chronic Disease Management
University of Virginia
NCT03676465
6-month Comparison of Morning Lantus Versus Neutral Protamine Hagedorn Insulin in Young Children With Type 1 Diabetes
Sanofi
NCT00993473
Initiation of Continuous Glucose Monitoring at Diagnosis of Type 1 Diabetes
Korey Hood
NCT02734667
Efficacy of Continuous Glucose Monitoring in Subjects With Type 1 Diabetes Mellitus on Multiple Daily Injections (MDI) or Continuous Subcutaneous Insulin Infusion (CSII) Therapy
DexCom
NCT01104142
Use of Continuous Glucose Sensors by Adolescents With Inadequate Diabetic Control
Nemours Children's Clinic
NCT00945659
Nutritional Intervention to Prevent Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00333554
A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12460A
Hanmi Pharmaceutical Company Limited
NCT01724814
New Glucose Sensor Pediatric
Medtronic Diabetes
NCT01161043
Gene Expression Profiling in Type 1 Diabetes
Children's Mercy Hospital Kansas City
NCT00330954
PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
Mesoblast
NCT00690066
Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus
Brigham and Women's Hospital
NCT00762671
Effect of Diabetes Mellitus on Cholesterol Metabolism
Medical College of Wisconsin
NCT00879710
A Cognitive Behavioral Therapy (CBT) Intervention to Reduce Fear of Hypoglycemia in Type 1 Diabetes
University of Illinois at Chicago
NCT03549104
The VRIF Trial: Hypoglycemia Reduction With Automated-Insulin Delivery System
University of Virginia
NCT03674281
Sleep and Glucose Regulation in Youth With Type 1 Diabetes Mellitus
University of Arizona
NCT00848822
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
University of Colorado, Denver
NCT03618420
Assess the Efficacy of the Low Glucose Suspend (LGS) Feature in the MiniMed Paradigm® X54 System
Medtronic Diabetes
NCT01148862
Islet Transplantation in Type 1 Diabetes
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00434811
Diabetic Kidney Alarm (DKA) Study
University of Colorado, Denver
NCT03128229
TAK-329 Glucose Clamp Study
Takeda
NCT01311076
Glycemic Profiles And Insulin Delivery Across The Menstrual Cycle In Women With Type 1 Diabetes
University of Virginia
NCT04665999
Medtronic Minimed Overnight Closed-Loop System
Bruce A. Buckingham
NCT01881009
Safety and Efficacy of Sotagliflozin (LX4211) in Patients With Inadequately Controlled Type 1 Diabetes Mellitus
Lexicon Pharmaceuticals
NCT01742208
Crossover Feasibility Study of Portable AP Device With Zone-MPC and HMS and Adapted I:C and Basal Insulin
Sansum Diabetes Research Institute
NCT01929798
Tissue-Specific Metabolic Reprogramming in Diabetic Complications
University of Michigan
NCT01823406
Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes
University of Alabama at Birmingham
NCT02372253
At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation
Sansum Diabetes Research Institute
NCT02705053
Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp
Daniel Chernavvsky, MD, CRC
NCT02604524
Adaptive Biobehavioral Control (ABC) of Automated Insulin Delivery
University of Virginia
NCT04784637
Hyaluronidase Effect on Infusion Set Life
Stanford University
NCT02199028
Intervention Groups for Adolescents With Type 1 Diabetes Mellitus
Children's Hospital and Health System Foundation, Wisconsin
NCT00622271
Neuropsychological and Neuroanatomical Studies of Young Children With and Without Type 1 Diabetes Mellitus
Stanford University
NCT00449891
Pediatric Diabetics Type 1 Using InsuPatch
Insuline Medical
NCT01368978
Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon
Massachusetts General Hospital
NCT02516150
Glucagon Rescue of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes Treated With Volagidemab
REMD Biotherapeutics
NCT06272695
Pregnancy Intervention With a Closed-Loop System (PICLS) Study
University of Colorado, Denver
NCT03774186
Efficacy of Islet After Kidney Transplantation
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00468117
Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Using Total Daily Insulin
University of Virginia
NCT03804983
Outpatient Control-to-Range: System and Monitoring Testing
University of Virginia
NCT01578980
The Multi-Sensor Distance Accuracy Study
Oregon Health and Science University
NCT02241993
To Evaluate the Effect on Post-prandial Glycemia Safety, and Tolerability of Viaject 7 vs. Lispro Insulin During Subcutaneous Insulin Pump Therapy
Biodel
NCT01110746
A Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Doses of SAR438544 in Comparison to Placebo and Glucagon in Healthy Subjects and Type 1 Diabetes Mellitus Patients
Sanofi
NCT02625636
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
University of Texas Southwestern Medical Center
NCT03655067
Detemir: Role in Type 1 Diabetes
Montefiore Medical Center
NCT00564395
The Effect of Insulin Glulisine Compared With Insulin Aspart on Breakfast Post Prandial Glucose Levels in Prepubertal Children
Corewell Health West
NCT00913497
A Clinical Study of the Performance of a Glucose Blinding Protein-Based Continuous Glucose Monitor (GBP CGM)
University of Virginia
NCT01469715
T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs
University of California, San Francis
NCT01210664
T1DM Immunotherapy Using Polyclonal Tregs + IL-2
Jeffrey Bluestone
NCT02772679
Development of an Advisory System for Glycemic Control During the Menstrual Cycle in Patient With Type 1 Diabetes
University of Virginia
NCT01653210
A Pilot Study of Moderate Hyperbilirubinemia in Type 1 Diabetes Mellitus
Brigham and Women's Hospital
NCT01421355
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 19 |
| Phase 2 | 16 |
| Phase 3 | 14 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 1 Diabetes Mellitus Trial Landscape
ClinicalTrials.gov lists 106 US studies indexed under Type 1 Diabetes Mellitus, and 23 of those are currently open to recruitment — roughly 22% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Type 1 Diabetes Mellitus shows 19 late-stage studies (Phase 3 and Phase 4 combined) alongside 35 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Type 1 Diabetes Mellitus is led by University of Virginia with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 1 Diabetes Mellitus?
PlainTrial tracks 106 US clinical trials for Type 1 Diabetes Mellitus, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 1 Diabetes Mellitus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.