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NCT07221617 · ClinicalTrials.gov registry record · Phase 4
Oral Methadone in Cardiac Surgery
A Phase 4 study of Pain, Postoperative and Anesthesia, sponsored by Mayo Clinic.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT07221617: Recruiting Phase 4 study of Pain, Postoperative and Anesthesia, sponsored by Mayo Clinic.
NCT07221617 is a Phase 4 study of Pain, Postoperative and Anesthesia that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 100 participants, below the 272-participant average among 113 other Pain, Postoperative trials with a reported enrollment target (63% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07221617, a Phase 4 study of Pain, Postoperative and Anesthesia, is actively recruiting participants, sponsored by Mayo Clinic.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.
Primary Outcome
Opioid medication used at 72 hours post-extubation will be reported in morphine milligram equivalents
Conditions Studied
Interventions
- DRUG Methadone, oral
- DRUG Methadone, intravenously
Study Locations (1)
Minnesota
- Mayo Clinic in Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2026-01-13 |
| Est. Completion | 2026-08 |
| Phase | Phase 4 |
What NCT07221617 shows while recruiting
NCT07221617 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 272-participant average among 113 other Pain, Postoperative trials with a reported enrollment target (63% lower).
The record links to 3 conditions, with Pain, Postoperative appearing as the primary indexed condition, and to 2 interventions - of which Methadone, oral is the first listed.
NCT07221617 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT07221617 about?
NCT07221617 is a clinical study titled "Oral Methadone in Cardiac Surgery". The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.
What is the current status of trial NCT07221617?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 100 participants. The study started on 2026-01-13. Estimated completion is 2026-08.
What conditions does trial NCT07221617 study?
This clinical trial studies the following conditions: Pain, Postoperative, Anesthesia, Cardiac Surgery.
What interventions are being tested in trial NCT07221617?
The interventions under investigation include: Methadone, oral (DRUG), Methadone, intravenously (DRUG).
Who is sponsoring clinical trial NCT07221617?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07221617 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain, Postoperative
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07221617's enrollment target sits among peer trials
100 44th of 113 higher than 67 of 113 other Pain, Postoperative trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain, Postoperative trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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