Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Healthy Volunteer
Open-data reference.
113 US clinical trials · 49 currently recruiting
Active & Recent Trials
Studies of Blood Flow to the Brain During Thought
National Institute of Mental Health (NIMH)
NCT00001360
Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies
National Institute of Mental Health (NIMH)
NCT03304665
Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05078905
Characterization of Diseases With Salivary Gland Involvement
National Institute of Dental and Craniofacial Research (NIDCR)
NCT02327884
Study of New Magnetic Resonance Imaging Methods of the Brain
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00004577
Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)
National Institute of Dental and Craniofacial Research (NIDCR)
NCT01568697
Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy
National Cancer Institute (NCI)
NCT02821806
Normal Values in Hearing and Balance Testing
National Institute on Deafness and Other Communication Disorders (NIDCD)
NCT01629108
Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03878121
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
National Institute of Mental Health (NIMH)
NCT01266577
Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol
Akiva Mintz
NCT07012993
Ultralow Dose PET Imaging of 18F-FDG Uptake
Akiva Mintz
NCT06956391
Ultralow Dose PET Imaging for 18F-NaF Uptake
Akiva Mintz
NCT07284563
Ultralow Dose PET Imaging for PSMA Expression
Akiva Mintz
NCT06904313
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Yale University
NCT06624137
Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial
National Institute on Aging (NIA)
NCT06274749
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
National Institute of Mental Health (NIMH)
NCT03065335
Collection of Data and Samples From Healthy Donors for Use in Translational Research
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00090662
Early Metabolic Effects of Dolutegravir or Tenofovir Alefenamide in Healthy Volunteers
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05652478
A Study to Learn More About the Safety of BIIB145 and How it is Processed in the Body of Healthy Adult Participants
Biogen
NCT07225517
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Washington University School of Medicine
NCT04354064
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
University of Pennsylvania
NCT03721822
A Study to Assess How the Drug Moves Through the Body, Adverse Events, and Tolerability of Oral ABBV-722 Capsules of Single and Multiple Ascending Doses in Adult Participants and Single Doses in Adult Asian Participants
AbbVie
NCT06673238
A Study to Evaluate How the Study Drug Moves Through the Body, Adverse Events, and How the Body Tolerates ABBV-547 Injections
AbbVie
NCT07232004
Phosphatidylethanol and Other Ethanol Consumption Markers
The University of Texas Health Science Center at San Antonio
NCT06747364
Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
University of Alabama at Birmingham
NCT06989320
Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06223555
A Study to Learn About the Safety of BIIB142 and How it is Processed in the Body of Healthy Adult Participants Aged 18 to 55 Years Old
Biogen
NCT07133828
A First-in-Human Single and Multiple Ascending Dose Study of MT-201
Mirador Therapeutics
NCT07219368
Study About Whether Atirmociclib/PF-07220060 Proportionally Increases Exposure as Dose Increases in Healthy Participants
Pfizer
NCT07215078
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
Suninflam
NCT07051629
A Study to Learn How the Body Processes BIIB141 (Omaveloxolone) When Taken as a Capsule or as a Tablet Dissolved in Liquid, and to Learn About Its Safety in Healthy Adults Ages 18 to 55
Biogen
NCT07297199
A Study to Compare Blood Levels of Different Dosage Formulations of the Study Medicine That Is a CGRP Receptor Antagonist in Healthy Adults
Pfizer
NCT07261371
A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults
Astellas Pharma Global Development
NCT07395024
Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT06819189
A Study to Assess the Adverse Events and How Oral ABBV-1042 Moves Through the Body of Healthy Adult Participants
AbbVie
NCT07222709
Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination
Basilea Pharmaceutica
NCT06733675
Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus
ChromaDex
NCT07251608
A Study to Assess How the Body Absorbs ABBV-8736 Subcutaneous Injections Relative to Intravenous Injections in Adult Healthy Volunteers
AbbVie
NCT07413133
Healthy Volunteer Study
InventisBio Co.
NCT07270783
A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants
AbbVie
NCT07219030
Avocado and Postprandial Responses
University of Vermont Medical Center
NCT06818032
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
Vanderbilt University Medical Center
NCT06609356
Power Nap With TES-TI
University of Wisconsin, Madison
NCT07090135
Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers
Johns Hopkins University
NCT07349758
Neuroinflammation Imaging in AD
University of Pennsylvania
NCT04274998
A Study of ABBV-295 Subcutaneous Injections to Assess Pharmacokinetics and Adverse Events in Healthy Adult Women Participants With Overweight or Obesity Taking Oral Contraceptives
AbbVie
NCT07414784
Relative Bioavailability of NX-5948 Tablets vs Capsules and the Effect of Covariates on the PK of NX-5948 Tablets
Nurix Therapeutics
NCT06717269
Psychedelic Virtual Reality
Yale University
NCT06581263
A Study to Find Out How Litifilimab is Processed in the Body in Healthy Participants When Given Under the Skin in 3 Different Ways
Biogen
NCT06741657
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Single Ascending Subcutaneous or Intravenous Doses of ABBV-701 in Healthy Adult Western and Asian Participants
AbbVie
NCT06895343
A Study to Assess the Adverse Events and How Subcutaneous (SC) Injections and Intravenous (IV) Infusions of ABBV-142 Move Through the Body of Healthy Adult Participants
AbbVie
NCT06774313
Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CT
University of Pennsylvania
NCT02815917
A Multi-part Study of ALG-000184 to Evaluate Safety, Tolerability, Pharmacokinetics and Drug-drug Interaction Potential After Single and Multiple Doses in Healthy Volunteers
Aligos Therapeutics
NCT06672900
A Study to Evaluate Adverse Events, How the Drug is Tolerated, and How the Drug Moves Through the Body of Intravenous Infusions of ABBV-8736 in Adult Healthy Volunteers
AbbVie
NCT07141199
A Study to Assess Adverse Events and How Oral ABBV-932 Moves Through the Body When Given With Oral Itraconazole in Healthy Adult Participants
AbbVie
NCT07071532
Comparison of Pharmacokinetic Responses to Three Ketone Esters
NeuroEnergy Ventures
NCT07289165
Evaluation of Neuroinflammation in Parkinson's Disease Using 18F-NOS PET/CT
University of Pennsylvania
NCT04062526
A Study to Assess the Relative Bioavailability of Oral ABBV-932 in Healthy Adult Participants
AbbVie
NCT06849791
A Phase 1 Study of Mosliciguat in Healthy, Adult Males
Pulmovant
NCT07185321
Mental Health Impact of COVID-19 Pandemic on NIMH Research Participants and Volunteers
National Institute of Mental Health (NIMH)
NCT04339790
A Screening Study To Assess The Cognition Status in Healthy Volunteers
Hoffmann-La Roche
NCT01926873
Spaced Versus Massed Skill Learning
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00426465
A Study to Evaluate the Bioequivalence of Tocilizumab Following Subcutaneous Administration Via an Autoinjector (AI 1000-G2) Versus a Pre-Filled Syringe in Healthy Volunteers
Hoffmann-La Roche
NCT02678988
A Study of The Abuse Liability Potential of RO4917838 in Recreational Drug Users
Hoffmann-La Roche
NCT01438749
Study Assessing the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis
Proteostasis Therapeutics
NCT03140527
Bioequivalence Study of Denosumab CP4 Drug Product and Commercially Available Denosumab CP2 Drug Product
Amgen
NCT02053753
Drug-Drug Interaction Study With AZD9291 and Omeprazole in Healthy Volunteers
AstraZeneca
NCT02224053
Estimating Brain Biomechanics Using MRI
National Institutes of Health Clinical Center (CC)
NCT01633268
Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04025580
A Study to Determine the Safety, Tolerability, and Pharmacokinetics of GDC-0310 in Healthy Volunteers
Genentech
NCT02742779
Study to Assess the Safety, Tolerability, PK, ECG Effects, Food Effect, and Drug-drug Interaction (DDI) of Hormonal Contraceptives of PTI-428 in Healthy Female Volunteers
Proteostasis Therapeutics
NCT02846142
A Drug-Drug Interaction Study of the Effect of Rabeprazole, Itraconazole or Fluconazole on the Pharmacokinetics of Vismodegib
Genentech
NCT01772290
A Study of Danoprevir in Healthy Volunteers And Patients With Hepatic Impairment
Hoffmann-La Roche
NCT01185873
Phase I Study to Evaluate Bioavailability of Overencapsulated Celecoxib
POZEN
NCT00729495
A Study to Evaluate the Effect of Particle Size, Formulation and Food on the Pharmacokinetics of GDC-0032 in Healthy Volunteers
Genentech
NCT01980953
A Study to Evaluate the Bioavailability and Food Effects of Oral Venetoclax New Tablet Formulation 2.0 in Healthy Adult Female Participants
AbbVie
NCT06742086
Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men
Genzyme, a Sanofi Company
NCT01674036
Efficacy of B7A BSIgG Against E. Coli Strain B7A Challenge
Johns Hopkins Bloomberg School of Public Health
NCT03040687
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Single Ascending Doses of CC-92480 in Healthy Subjects
Celgene
NCT03803644
A Study to Assess the Impact of Speed and Site of Subcutaneous Injection on Pain, Tolerability, Safety, and Pharmacokinetics of Gantenerumab in Healthy Participants
Hoffmann-La Roche
NCT02882009
A Study to Investigate the Effects of Brensocatib on QT Interval in Healthy Participants
Insmed Incorporated
NCT05355935
Effect of Food on the Pharmacokinetics of Apremilast (CC-10004) in Healthy Adults
Amgen
NCT01634178
A Study of Aleglitazar in Combination With Aspirin in Healthy Volunteers
Hoffmann-La Roche
NCT01188304
A Pharmacodynamic and Pharmacokinetic Study of RO5508887 in Healthy Volunteers
Hoffmann-La Roche
NCT01592331
Effects of Transcranial Magnetic Stimulation (TMS) on Somatosensory Perception
National Center for Complementary and Integrative Health (NCCIH)
NCT02119637
A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects
Supernus Pharmaceuticals
NCT03844906
Study of Bemnifosbuvir in Subjects With Normal and Impaired Hepatic Function
Atea Pharmaceuticals
NCT05724693
Safety, Tolerability and PK/PD of RB006 in a Healthy Volunteer SAD
Regado Biosciences
NCT01872572
A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers
Genentech
NCT01814709
A Study to Evaluate Safety and Pharmacokinetics of BIIB104 in Healthy Japanese and Non-Japanese Participants
Biogen
NCT05148481
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Healthy Volunteers
Genentech
NCT02596399
A Study of the Effects of Food and Cobicistat on Plixorafenib Pharmacokinetics in Healthy Volunteers.
Fore Biotherapeutics
NCT06385119
A Drug-Drug Interaction Study Between PF-06882961 and PF-06865571 in Healthy Adult Participants and Overweight Adults or Adults With Obesity Who Are Otherwise Healthy
Pfizer
NCT04839393
Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers
Vanda Pharmaceuticals
NCT04849559
A Study to Examine the Effects of Entinostat on Midazolam in Healthy Adult Subjects
Syndax Pharmaceuticals
NCT03187015
GSK1349572 Drug Interaction Study With Atazanavir/Ritonavir and Atazanavir
GlaxoSmithKline
NCT00883935
A Pharmacokinetic Study on Co-administration of Tamiflu (Oseltamivir) and Rimantadine in Healthy Volunteers
Hoffmann-La Roche
NCT01172847
A Phase I Dose Escalation Study of Plerixafor in Healthy Subjects of Japanese Descent
Genzyme, a Sanofi Company
NCT01579149
Safety, Tolerability, and Pharmacokinetics of IRL201104 in Healthy Volunteers
Revolo Biotherapeutics
NCT05921591
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 80 |
| Phase 2 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Healthy Volunteer Trial Landscape
ClinicalTrials.gov lists 113 US studies indexed under Healthy Volunteer, and 49 of those are currently open to recruitment — roughly 43% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Healthy Volunteer shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 86 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Healthy Volunteer is led by AbbVie with 15 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Healthy Volunteer?
PlainTrial tracks 113 US clinical trials for Healthy Volunteer, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Healthy Volunteer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.