Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
NCT05722002 · View on ClinicalTrials.gov ↗
Study Summary
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when compared to the opioid group.
Conditions Studied
Interventions
- DRUG Acetaminophen
- DRUG NSAID
- DRUG Opioid
Study Locations (8)
Michigan
- University of Michigan — Ann Arbor
- Henry Ford Health System — Detroit
Ontario
- Women's College Hospital — Toronto
- Unity Health Toronto — Toronto
Missouri
- Washington University in Saint Louis — St Louis
New Jersey
- Cooper University Health Care — Camden
North Carolina
- University of North Carolina Hospitals — Chapel Hill
Pennsylvania
- Temple University - Temple Health — Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 900 participants |
| Start Date | 2023-02-06 |
| Est. Completion | 2026-10 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05722002
The ClinicalTrials.gov registry entry for NCT05722002 describes a study currently listed as recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 900 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Michigan, which has 1,126 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Surgery appearing as the primary indexed condition, and to 3 interventions — of which Acetaminophen is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05722002 reports 8 study locations spanning 6 distinct geographic areas — top geographies include Michigan, Ontario, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05722002 about?
NCT05722002 is a clinical study titled "Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial". This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal An...
What is the current status of trial NCT05722002?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 900 participants. The study started on 2023-02-06. Estimated completion is 2026-10.
What conditions does trial NCT05722002 study?
This clinical trial studies the following conditions: Surgery, Pain, Postoperative. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05722002?
The interventions under investigation include: Acetaminophen (DRUG), NSAID (DRUG), Opioid (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05722002?
This trial is sponsored by University of Michigan, which has 1,126 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05722002 being conducted?
This trial has 8 study locations across Michigan, Missouri, New Jersey, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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