Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05722002 · ClinicalTrials.gov registry record · Phase 4
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
A Phase 4 study of Surgery and Pain, Postoperative, sponsored by University of Michigan.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 900
- Enrollment target
- 8
- Study locations
NCT05722002: Recruiting Phase 4 study of Surgery and Pain, Postoperative, sponsored by University of Michigan.
NCT05722002 is a Phase 4 study of Surgery and Pain, Postoperative that is actively recruiting participants, run by University of Michigan. The registered enrollment target is 900 participants, below the 52,844-participant average among 120 other Surgery trials with a reported enrollment target (98% lower). The trial reports 8 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05722002, a Phase 4 study of Surgery and Pain, Postoperative, is actively recruiting participants, sponsored by University of Michigan.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 900 participants
- Enrollment target
- 8
- Study locations
Study Summary
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when compared to the opioid group.
Primary Outcome
This is a one question survey in which the worst pain intensity recorded (0-10 being the worst) will be used.
Conditions Studied
Interventions
- DRUG Acetaminophen
- DRUG NSAID
- DRUG Opioid
Study Locations (8)
Michigan
- University of Michigan - Ann Arbor
- Henry Ford Health System - Detroit
Ontario
- Women's College Hospital - Toronto
- Unity Health Toronto - Toronto
Missouri
- Washington University in Saint Louis - St Louis
New Jersey
- Cooper University Health Care - Camden
North Carolina
- University of North Carolina Hospitals - Chapel Hill
Pennsylvania
- Temple University - Temple Health - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 900 participants |
| Start Date | 2023-02-06 |
| Est. Completion | 2026-10 |
| Phase | Phase 4 |
What NCT05722002 shows while recruiting
NCT05722002 is an interventional study that assigns participants to a tested intervention. The registered 900 participants enrollment target is mid-sized for trials with a published cap, below the 52,844-participant average among 120 other Surgery trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Surgery appearing as the primary indexed condition, and to 3 interventions - of which Acetaminophen is the first listed.
NCT05722002 lists 8 locations in 6 states (Michigan, Ontario, Missouri).
Frequently Asked Questions
What is clinical trial NCT05722002 about?
NCT05722002 is a clinical study titled "Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial". This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal An...
What is the current status of trial NCT05722002?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 900 participants. The study started on 2023-02-06. Estimated completion is 2026-10.
What conditions does trial NCT05722002 study?
This clinical trial studies the following conditions: Surgery, Pain, Postoperative.
What interventions are being tested in trial NCT05722002?
The interventions under investigation include: Acetaminophen (DRUG), NSAID (DRUG), Opioid (DRUG).
Who is sponsoring clinical trial NCT05722002?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05722002 being conducted?
This trial has 8 study locations across Michigan, Missouri, New Jersey, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Surgery
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05722002's enrollment target sits among peer trials
900 13th of 120 higher than 107 of 120 other Surgery trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Surgery trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
RECRUITING · Phase 4
-
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
RECRUITING · Phase 4
-
Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery
RECRUITING · Phase 4
-
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
RECRUITING · Phase 4
-
Lovenox 30 mg Twice Daily (BID) Versus 40 mg Once Daily (QD)
RECRUITING · Phase 4
-
Multimodal Analgesia Effect on Post Surgical Patient
ACTIVE NOT RECRUITING · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02352116 · 900 participants · NA
Evaluation of Post-PACU Pain Management in Pediatric Surgery
- NCT02414347 · 900 participants
F 18 T807 Tau PET Imaging of Alzheimer's Disease
- NCT02670408 · 900 participants
Diagnostic and Therapeutic Applications of Microarrays in Heart Transplantation
- NCT02960022 · 900 participants · Phase 2
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI