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Osteoarthritis, Knee: full-pipeline trial registry
45 of 115 indexed Osteoarthritis, Knee trials are currently recruiting.
Corpus placement: #110 of 28,707 conditions by registered trial count.
115 US clinical trials · 45 currently recruiting · #110 of 28,707 conditions by registered trial count
Osteoarthritis, Knee: 115 US clinical trials tracked, 45 recruiting.
Osteoarthritis, Knee is the subject of 115 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 23 are in Phase 3-4 (later-stage) and 34 in Phase 1-2 (earlier-stage). The most active sponsor is Regeneron Pharmaceuticals, running 4 of these trials.
Enrollment posture brief
Registry condition osteoarthritis-knee
OPEN 45 | RECR 39% | LATE 23 | EARLY 34 | RANK #110 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Advanced Non-Small-Cell Lung Cancer (39% recruiting · 23 trials)
Osteoarthritis, Knee lists 45 open slots (39% of 115 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Osteoarthritis, Knee on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Osteoarthritis, Knee is recruiting above its size-band peers.
45 of 115 indexed trials (39.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Osteoarthritis, Knee trials is spread across many organizations.
Regeneron Pharmaceuticals accounts for 4 of 115 trials (3.5%). 90 distinct sponsors appear on at least one study for this condition label.
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Typical Osteoarthritis, Knee enrolment sits around 120 participants.
Median target enrolment is 120 among the 113 trials that report a genuine target (sentinel values excluded). 44 of those (38.9%) plan for fewer than 100 participants.
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Osteoarthritis, Knee research is mostly interventional.
104 interventional and 11 observational studies make up this index (90.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
115 total, page 1 of 3
Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain
University of Missouri-Columbia
NCT03711773
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Eli Lilly and Company
NCT05986292
The Osteoarthritis Prevention Study
Wake Forest University
NCT05946044
Embo Registry; National Registry for Artery Embolization
Vascular Solutions of North Carolina
NCT06477965
Physica System Total Knee Replacement Registry Study
Limacorporate S.p.a
NCT03048201
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
NCT05787821
Preventing Injured Knees From osteoArthritis: Severity Outcomes
Brigham and Women's Hospital
NCT06096259
A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.
Paradigm Biopharmaceuticals
NCT06917404
An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Joint
Ageless Biotech
NCT06485843
Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty
Chad Brummett
NCT06234631
Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
ZetrOZ
NCT06257537
Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans
VA Office of Research and Development
NCT06488144
ZYNRELEF for Pain Management in Total Knee Arthroplasty
Baptist Health South Florida
NCT05644496
Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
Steven E Harte, PhD
NCT04992624
Triamcinolone Ketorolac (TriKe) Knee Trial
United Health Services Hospitals
NCT05336968
Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement
Geisinger Clinic
NCT04732962
Optimizing Pain Self-Management in Total Knee Arthroplasty
University of Virginia
NCT06038240
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Vanderbilt University Medical Center
NCT06083480
A Phase 2b/3a Study to Evaluate the Efficacy and Safety of JointStem in Patients Diagnosed as Knee Osteoarthritis
Nature Cell Co.
NCT04368806
Oral Steroid Taper After Total Knee Arthroplasty
Columbia University
NCT07070882
Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
Mayo Clinic
NCT06887829
Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee
Palo Alto Veterans Institute for Research
NCT05700682
Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes
University of Kansas Medical Center
NCT06478186
Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis
R3 Medical Research
NCT06608134
MISHA Post-Market Clinical Study
Moximed
NCT06118892
Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury
University of North Carolina, Chapel Hill
NCT04875052
MOTION Clinical Trial
Moximed
NCT06843980
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
LifeBridge Health
NCT04814082
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Healeon Medical
NCT04238143
Navio Robotic Versus Conventional Total Knee Arthroplasty
Columbia University
NCT03519269
Effect of Anti-inflammatory Diet in Osteoarthritis
University of California, San Diego
NCT06080347
Gait Rehabilitation to Treat FastOA
University of North Carolina, Chapel Hill
NCT05848622
Non-invasive Evaluation of Upper and Lower Body Function With Showmotion
University of Colorado, Denver
NCT04137835
The Role of Vitamin K on Knee Osteoarthritis Outcomes
Boston University
NCT06385275
Mobilizing Hispanics With Knee Osteoarthritis
University of Arizona
NCT06522906
Positive Minds Strong Joints for Knee Osteoarthritis
Boston University Charles River Campus
NCT06493903
Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
Wake Forest University Health Sciences
NCT04427709
Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis
Stanford University
NCT06208631
CBD for Knee Osteoarthritis
University of Florida
NCT06414473
Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
University of California, San Diego
NCT05559463
Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2)
Augusta University
NCT06058169
A Hip Flexion Feedback System for Exercise Monitoring in Individuals With Osteoarthritis and Obesity
University of Southern Mississippi
NCT05997862
Geniculate Artery Embolization for Osteoarthritis
University of Minnesota
NCT04456569
Bayer OA Knee Pain Pilot
Medical University of South Carolina
NCT05349682
Bone Marrow Aspirate Concentrate (BMAC)Treatment for Knee Osteoarthritis
University of California, San Diego
NCT04716803
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Eli Lilly and Company
NCT05929066
Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
Paradigm Biopharmaceuticals USA (INC)
NCT04809376
A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
Amzell
NCT06693648
Pain & Aging: Combined Interventions for Fitness in the Community Study
University of Washington
NCT04099394
Clinical Outcomes of Joint Arthroplasty
St. Helena Hospital Coon Joint Replacement Institute
NCT03668691
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 17 |
| Phase 2 | 17 |
| Phase 3 | 14 |
| Phase 4 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Osteoarthritis, Knee records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Osteoarthritis, Knee trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Osteoarthritis, Knee page
115 registered trials, 45 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 45 Osteoarthritis, Knee trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Regeneron Pharmaceuticals sponsors the most Osteoarthritis, Knee trials on record, review their full trial history before evaluating a specific study. See Regeneron Pharmaceuticals's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Osteoarthritis, Knee condition card totals 115 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.