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Knee Osteoarthritis: full-pipeline trial registry
41 of 102 indexed Knee Osteoarthritis trials are currently recruiting.
Corpus placement: #134 of 28,707 conditions by registered trial count.
102 US clinical trials · 41 currently recruiting · #134 of 28,707 conditions by registered trial count
Knee Osteoarthritis: 102 US clinical trials tracked, 41 recruiting.
Knee Osteoarthritis is the subject of 102 registered US clinical trials on ClinicalTrials.gov, 41 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Northwestern University, running 3 of these trials.
Enrollment posture brief
Registry condition knee-osteoarthritis
OPEN 41 | RECR 40% | LATE 14 | EARLY 17 | RANK #134 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Metastatic Cancer (40% recruiting · 117 trials)
Knee Osteoarthritis lists 41 open slots (40% of 102 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Knee Osteoarthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Knee Osteoarthritis is recruiting above its size-band peers.
41 of 102 indexed trials (40.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Knee Osteoarthritis trials is spread across many organizations.
Northwestern University accounts for 3 of 102 trials (2.9%). 77 distinct sponsors appear on at least one study for this condition label.
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Typical Knee Osteoarthritis enrolment sits around 83 participants.
Median target enrolment is 83 among the 102 trials that report a genuine target (sentinel values excluded). 56 of those (54.9%) plan for fewer than 100 participants.
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Knee Osteoarthritis research is mostly interventional.
88 interventional and 14 observational studies make up this index (86.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
102 total, page 1 of 3
Innovations in Genicular Outcomes Registry
Pacira Pharmaceuticals
NCT05495334
General vs Spinal in Total Joint Arthroplasty (TJA)
University of Miami
NCT06747494
A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension
Canary Medical
NCT06040827
Remote Tai Chi for Knee Osteoarthritis
Tufts Medical Center
NCT06384898
Return to Golf After Orthopaedic Surgery
Hospital for Special Surgery, New York
NCT05675618
Persona Revision Knee System Outcomes
Zimmer Biomet
NCT04821154
Live and Interactive Fitness Training Program (Vivo Knee OA)
Intermountain Health Care
NCT06462560
Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
The Cleveland Clinic
NCT06298721
Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults With Knee Osteoarthritis
University of Michigan
NCT06580561
The Effects of Patient and Visit Characteristics on Health Outcomes in Knee Osteoarthritis
University of California, Davis
NCT06574191
Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain
University of Alabama at Birmingham
NCT05785884
Treadmill Perturbation Training for Fall Prevention After Total Knee Replacement
University of Illinois at Chicago
NCT05736666
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
Northwestern University
NCT06245109
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis
Syntr Health Technologies
NCT05526898
BioPoly® Partial Resurfacing Knee Implant IDE
BioPoly
NCT06915363
Investigating Patient Satisfaction With Smart Knee Implants
University of Chicago
NCT06968143
Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA
Massachusetts General Hospital
NCT05839535
A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis
4Moving Biotech
NCT07225829
Gait Analysis of a Lateral-Pivot Design Total Knee Replacement
More Foundation
NCT04275362
Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
University of Chicago
NCT06781463
Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis
Endeavor Health
NCT03491761
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
LifeBridge Health
NCT04814082
Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
University of California, Los Angeles
NCT04682652
Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation
Yale University
NCT06407427
Mechanical Alignment Vs Kalipered Kinematic Alignment Total Knee Arthroplasty
Northwestern University
NCT06617871
Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial
University of California, Davis
NCT04472702
Optimal Anesthetic for Corticosteroid Injections for Knee Osteoarthritis
Foundation for Orthopaedic Research and Education
NCT05906433
Gait Rehabilitation to Treat FastOA
University of North Carolina, Chapel Hill
NCT05848622
Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty
University of Miami
NCT06902285
Telehealth Exercise and Mindfulness for Pain in Osteoarthritis - Stage 1B
Boston University Charles River Campus
NCT06684587
Knee Biofeedback Rehabilitation Through Game Therapy
Barron Associates
NCT06090097
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
University of Texas, El Paso
NCT06105788
Effects of Gait Retraining on Lower Extremity Biomechanics
George Mason University
NCT03663790
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
University of Chicago
NCT06859164
Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis
University of Colorado, Denver
NCT06940479
A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
University of California, Los Angeles
NCT06906939
Dronabinol After Arthroscopic Surgery
Northwestern University
NCT05335252
ROAM OA: Functional and Patient Reported Outcomes Wearing a Knee Brace for Unicompartmental OA
Rush University Medical Center
NCT07224958
The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis
University of Colorado, Denver
NCT03014401
Ischemic Preconditioning in Osteoarthritis and Back Pain
University of Illinois at Chicago
NCT07003113
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
Kessler Foundation
NCT05596591
Knee Arthroplasty Activity Trial
Brigham and Women's Hospital
NCT04107649
Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)
Brooke Army Medical Center
NCT03747393
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
Medacta U
NCT03211663
GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)
Merit Medical Systems
NCT05818150
Maximizing Patient Goal Attainment
Dartmouth-Hitchcock Medical Center
NCT05652270
JOURNEY II XR Safety and Effectiveness PMCF
Smith & Nephew
NCT03136887
Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
Lipogems International spa
NCT06121882
Post Market Clinical Follow-Up Study for EVOLUTION® BIOFOAM® Tibia and EVOLUTION® CS/CR Porous Femur
MicroPort Orthopedics
NCT04301622
Early Outcomes of MAKO Medial Unicompartmental Knee Arthroplasty
Washington University School of Medicine
NCT05736601
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 9 |
| Phase 3 | 6 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Knee Osteoarthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Knee Osteoarthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Knee Osteoarthritis page
102 registered trials, 41 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 41 Knee Osteoarthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Northwestern University sponsors the most Knee Osteoarthritis trials on record, review their full trial history before evaluating a specific study. See Northwestern University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Knee Osteoarthritis condition card totals 102 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.