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NCT07225829 · ClinicalTrials.gov registry record · Phase 2
A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis
A Phase 2 study of Knee Osteoarthritis and Synovitis of Knee, sponsored by 4Moving Biotech.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 129
- Enrollment target
- 20
- Study locations
NCT07225829 is a Phase 2 study of Knee Osteoarthritis and Synovitis of Knee that is actively recruiting participants, run by 4Moving Biotech. The registered enrollment target is 129 participants, below the 303-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (57% lower). The trial reports 20 study locations across 3 states.
The verdict
NCT07225829, a Phase 2 study of Knee Osteoarthritis and Synovitis of Knee, is actively recruiting participants, sponsored by 4Moving Biotech.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 129 participants
- Enrollment target
- 20
- Study locations
Study Summary
This phase 2a trial is an international, multicenter, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of one single intra-articular (IA) injection of 4P004 or placebo in: * patients between 40 and 80 years of age, * with synovitis and grade 2 to 4 osteoarthritis (OA) of the knee according to Kellgren and Lawrence (KL) classification.
Conditions Studied
Interventions
- DRUG 4P004
- DRUG Placebo (NaCl 0.9%)
Study Locations (20)
Other
- Durham Bone and Joint Specialists - Ajax
- SJHC London Rheumatology Centre - London
- G.R.M.O. (Groupe de recherche en maladies osseuses) Inc - Québec
- Parker Institute Bispebjerg, Frederiksberg Hospital - Frederiksberg
- Sanos Clinic Herlev - Herlev
- CHU Montpellier - Montpellier
- ChU de Nice - Nice
- Hôpital Cochin - Paris
- Hôpital Lariboisière - Paris
- Centre Hospitalier Universitaire CHU de Reims - Hopital Maison Blanche - Reims
- Care Access Kraków - Krakow
- Centrum Medyczne Reuma Park - Warsaw
- MICS Centrum Medyczne Warszawa - Warsaw
- Complejo Hospitalario Universitario de A Coruna - Hospital Universitario de A Coruna - A Coruña
- HLA Clínica Vistahermosa - Alicante
- Corporacio Sanitaria Parc Tauli - Hospital de Sabadell - Sabadell
- Hospital Universitario Marques de Valdecilla - Santander
- Clinica Nuestra Senora de la Esperanza - Santiago de Compostela
Illinois
- Northwestern University Feinberg School of Medicine - Chicago
Massachusetts
- Skylight Health Research Burlington - Burlington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 129 participants |
| Start Date | 2025-06-17 |
| Est. Completion | 2026-05 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07225829
The ClinicalTrials.gov registry entry for NCT07225829 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 129 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 303-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (57% lower). The listed sponsor is 4Moving Biotech, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Knee Osteoarthritis appearing as the primary indexed condition, and to 2 interventions - of which 4P004 is the first listed.
NCT07225829 reports 20 study locations spanning 3 distinct geographic areas - top geographies include Other, Illinois, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07225829 about?
NCT07225829 is a clinical study titled "A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis". This phase 2a trial is an international, multicenter, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of one single intra-articular (IA) injection of 4P004 or placebo in: * patients between 40 and 80 years of age, * with synovitis and grade 2 to 4 osteoarth...
What is the current status of trial NCT07225829?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 129 participants. The study started on 2025-06-17. Estimated completion is 2026-05.
What conditions does trial NCT07225829 study?
This clinical trial studies the following conditions: Knee Osteoarthritis, Synovitis of Knee.
What interventions are being tested in trial NCT07225829?
The interventions under investigation include: 4P004 (DRUG), Placebo (NaCl 0.9%) (DRUG).
Who is sponsoring clinical trial NCT07225829?
This trial is sponsored by 4Moving Biotech, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07225829 being conducted?
This trial has 20 study locations across Illinois, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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