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NCT04107649 · ClinicalTrials.gov registry record · NA
Knee Arthroplasty Activity Trial
A NA study of Knee Osteoarthritis and Total Knee Replacement, sponsored by Brigham and Women's Hospital.
- Active
- Registry status
- NA
- Development phase
- 600
- Enrollment target
- 5
- Study locations
NCT04107649: Active NA study of Knee Osteoarthritis and Total Knee Replacement, sponsored by Brigham and Women's Hospital.
NCT04107649 is a NA study of Knee Osteoarthritis and Total Knee Replacement that is active but no longer recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 600 participants, above the 299-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (101% higher). The trial reports 5 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04107649, a NA study of Knee Osteoarthritis and Total Knee Replacement, is active but no longer recruiting, sponsored by Brigham and Women's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 600 participants
- Enrollment target
- 5
- Study locations
Study Summary
Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA). As of 2013, the annual incidence of TKR was over 680,000 surgeries and annual costs exceeded $11 billion. Growing evidence suggests that while pain and functional status improve following TKR, physical activity (PA) typically does not surpass pre-TKR levels. Engagement in PA can meaningfully improve quality of life (QoL), pain, and function. Given the large investment in TKR, the effectiveness and cost-effectiveness of TKR could be substantially increased if TKR recipients became more physically active. The Knee Arthroplasty Activity Trial (KArAT) is a randomized controlled trial and participants will be randomly assigned to one of three arms. Participants across all arms will receive usual post-operative care for TKR surgery. Participants in the first arm will complete basic study activities, such as responding to surveys and attending two in-person clinic visits. Participants in the second arm will do the same and also receive a wrist-based physical activity tracker intervention. Participants in the third arm will receive a telephonic active coaching (motivational interviewing) and financial incentives (for reaching physical activity goals) (TAC(MI)+FI) based intervention, as well as a wrist-based physical activity tracker intervention. The second and third arms will be eligible to receive lottery-based financial rewards for wearing a wrist-worn activity tracker for twenty-four months during the study.
Primary Outcome
The primary outcome of this trial is the proportion of subjects who meet or surpass the PA threshold of 150 minutes per week of at least moderate physical activity, which is defined as 3 metabolic equivalents (METs), at 32-weeks post-TKR.
Conditions Studied
Interventions
- BEHAVIORAL Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives
- BEHAVIORAL Wrist based activity tracker wear
- OTHER Basic Study Activities
Study Locations (5)
Illinois
- Northwestern Memorial Hospital - Chicago
Kansas
- University of Kansas Medical Center - Kansas City
Massachusetts
- Brigham and Women's Hospital - Boston
Nebraska
- University of Nebraska Medical Center - Omaha
New York
- University at Buffalo - Buffalo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 2023-04-27 |
| Est. Completion | 2028-06-15 |
| Phase | NA |
What the registry record for NCT04107649 still lists
NCT04107649 is an interventional study that assigns participants to a tested intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap, above the 299-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (101% higher).
The record links to 2 conditions, with Knee Osteoarthritis appearing as the primary indexed condition, and to 3 interventions - of which Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives is the first listed.
NCT04107649 lists 5 locations in 5 states (Illinois, Kansas, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT04107649 about?
NCT04107649 is a clinical study titled "Knee Arthroplasty Activity Trial". Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA). As of 2013, the annual incidence of TKR was over 680,000 surgeries and annual costs exceeded $11 billion. Growing evidence su...
What is the current status of trial NCT04107649?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 600 participants. The study started on 2023-04-27. Estimated completion is 2028-06-15.
What conditions does trial NCT04107649 study?
This clinical trial studies the following conditions: Knee Osteoarthritis, Total Knee Replacement.
What interventions are being tested in trial NCT04107649?
The interventions under investigation include: Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives (BEHAVIORAL), Wrist based activity tracker wear (BEHAVIORAL), Basic Study Activities (OTHER).
Who is sponsoring clinical trial NCT04107649?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04107649 being conducted?
This trial has 5 study locations across Illinois, Kansas, Massachusetts, Nebraska, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Knee Osteoarthritis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04107649's enrollment target sits among peer trials
600 6th of 101 higher than 96 of 101 other Knee Osteoarthritis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Knee Osteoarthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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