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NCT06245109 · ClinicalTrials.gov registry record · Phase 4
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
A Phase 4 study of Knee Osteoarthritis, sponsored by Northwestern University.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 180
- Enrollment target
- 1
- Study location
NCT06245109: Recruiting Phase 4 study of Knee Osteoarthritis, sponsored by Northwestern University.
NCT06245109 is a Phase 4 study of Knee Osteoarthritis that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 180 participants, below the 303-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (41% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06245109, a Phase 4 study of Knee Osteoarthritis, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 180 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib, or placebo. Participants will have an Xray, knee MRI, brain MRI, blood draws, pain sensitivity testing, and asked to fill out questionnaires. The purpose of this study is to try to predict which participants will respond to the treatment.
Primary Outcome
At least 30% improvement from baseline in "weekly average daily pain" measured using a numeric rating scale (0-10) with 0 = no pain and 10 = worst pain
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Duloxetine
- DRUG Celecoxib
Study Locations (1)
Illinois
- Northwestern University - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2024-02-26 |
| Est. Completion | 2028-03-15 |
| Phase | Phase 4 |
What NCT06245109 shows while recruiting
NCT06245109 is an interventional study that assigns participants to a tested intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, below the 303-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (41% lower).
The record links to 1 condition, with Knee Osteoarthritis appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT06245109 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06245109 about?
NCT06245109 is a clinical study titled "Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis". This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment grou...
What is the current status of trial NCT06245109?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 180 participants. The study started on 2024-02-26. Estimated completion is 2028-03-15.
What conditions does trial NCT06245109 study?
This clinical trial studies the following conditions: Knee Osteoarthritis.
What interventions are being tested in trial NCT06245109?
The interventions under investigation include: Placebo (DRUG), Duloxetine (DRUG), Celecoxib (DRUG).
Who is sponsoring clinical trial NCT06245109?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06245109 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Knee Osteoarthritis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06245109's enrollment target sits among peer trials
180 26th of 101 higher than 76 of 101 other Knee Osteoarthritis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Knee Osteoarthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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