Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04682652 · ClinicalTrials.gov registry record · NA
Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis
A NA study of Knee Osteoarthritis and Degenerative Joint Disease of Knee, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT04682652: Recruiting NA study of Knee Osteoarthritis and Degenerative Joint Disease of Knee, sponsored by University of California, Los Angeles.
NCT04682652 is a NA study of Knee Osteoarthritis and Degenerative Joint Disease of Knee that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 100 participants, below the 304-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (67% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04682652, a NA study of Knee Osteoarthritis and Degenerative Joint Disease of Knee, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. Pain from arthritis is often due to underlying inflammation in the joint. The inflammation is associated with increased abnormal blood flow going to the specific area of pain. If the investigator can reduce the blood flow, the inflammation can be reduced and the pain can be controlled. The GAE procedure is an experimental procedure to decrease the blood flow (embolize) to the specific region of the knee that is causing the pain. This will be done by infusing microscopic spheres into the specific blood vessel (genicular artery) supplying the area of pain in the knee. This is done through a procedure which is called an angiogram, which is done entirely through a pinhole at the creased of the thigh, using twilight (conscious) sedation. The investigators have already completed an initial trial at UCLA, and shown that this procedure is safe and effective. The purpose of this new trial is to compare outcomes of people undergoing the GAE procedure to those who do not undergo the procedure. A total of 100 patients will be enrolled, and 2/3 of the patients will be randomly selected to undergo the GAE procedure. 1/3 will not undergo the procedure. This is known as a randomized trial. During the trial, all subjects will also get MRIs and fluid withdrawn from their knee joints at various timepoints in order to precisely figure out how the procedure works on a closer (microscopic) level.
Primary Outcome
The primary evaluation is the change in clinical response, measured by The Western Ontario and McMaster Universities Arthritis Index (WOMAC). The primary endpoint is percentage of subjects achieving at least a 50% reduction in WOMAC at 6 months with an intent-to-treat analysis.
Conditions Studied
Interventions
- DEVICE Embozene MicroSpheres
Study Locations (1)
California
- UCLA Santa Monica Hospital - Santa Monica
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2023-08-01 |
| Est. Completion | 2027-10-01 |
| Phase | NA |
What NCT04682652 shows while recruiting
NCT04682652 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 304-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (67% lower).
The record links to 2 conditions, with Knee Osteoarthritis appearing as the primary indexed condition, and to 1 intervention - of which Embozene MicroSpheres is the first listed.
NCT04682652 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04682652 about?
NCT04682652 is a clinical study titled "Genicular Artery Embolization Vs Observation for Symptomatic Knee Osteoarthritis". The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. Pain from arthritis is often due to underlying inflammation in the joint. The inflammation is associated with increased abnormal blood flow going...
What is the current status of trial NCT04682652?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2023-08-01. Estimated completion is 2027-10-01.
What conditions does trial NCT04682652 study?
This clinical trial studies the following conditions: Knee Osteoarthritis, Degenerative Joint Disease of Knee.
What interventions are being tested in trial NCT04682652?
The interventions under investigation include: Embozene MicroSpheres (DEVICE).
Who is sponsoring clinical trial NCT04682652?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04682652 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Knee Osteoarthritis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04682652's enrollment target sits among peer trials
100 42nd of 101 higher than 56 of 101 other Knee Osteoarthritis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Knee Osteoarthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis
RECRUITING · NA
-
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
RECRUITING · NA
-
Mechanical Alignment Vs Kalipered Kinematic Alignment Total Knee Arthroplasty
RECRUITING · NA
-
Investigating Patient Satisfaction With Smart Knee Implants
RECRUITING · NA
-
Gait Rehabilitation to Treat FastOA
RECRUITING · NA
-
Knee Biofeedback Rehabilitation Through Game Therapy
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01048281 · 100 participants
Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
- NCT01161199 · 100 participants
The Use of Leukapheresis to Support HIV Pathogenesis Studies
- NCT01327690 · 100 participants · Early Phase 1
Mental Health in Veterans and Families After Group Therapies
- NCT01730781 · 100 participants
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI