Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04821154 · ClinicalTrials.gov registry record
Persona Revision Knee System Outcomes
A clinical trial of Knee Osteoarthritis and Infection, sponsored by Zimmer Biomet.
- Recruiting
- Registry status
- 380
- Enrollment target
- 16
- Study locations
NCT04821154: Recruiting study of Knee Osteoarthritis and Infection, sponsored by Zimmer Biomet.
NCT04821154 is a study of Knee Osteoarthritis and Infection that is actively recruiting participants, run by Zimmer Biomet. The registered enrollment target is 380 participants, above the 301-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (26% higher). The trial reports 16 study locations across 13 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04821154, a study of Knee Osteoarthritis and Infection, is actively recruiting participants, sponsored by Zimmer Biomet.
- RECRUITING
- Registry status
- 380 participants
- Enrollment target
- 16
- Study locations
Study Summary
The study will evaluate the performance, clinical benefits and safety of the Persona Revision Knee System in patients who have received primary or revision total knee arthroplasty (TKA) treatment. This will be done using a multicenter, single-arm, consecutive series, retrospective cohort study with prospective follow-up.
Primary Outcome
The primary endpoint for this study will be performance assessed by improvement in the 1989 Knee Society Clinical Rating System (KS) objective knee score (KS-KS) from baseline to 2 years (as evaluated using the overall group mean showing at least the minimal clinically important difference \[MCID\] of 5.4 points) The Knee Society objective knee score (KS-KS) assesses the knee joint by awarding points for pain, stability, and range of motion, with a minimum possible score of 0 and maximum possib
Conditions Studied
Interventions
- DEVICE Persona Revision Knee System
Study Locations (16)
Arkansas
- Advanced Orthopaedic Specialists - Fayetteville
- Bowen Hefley Orthopedics - Little Rock
Indiana
- Orthopaedic Associates, Inc. - Evansville
- Jeff Yergler, LLC - Granger
Michigan
- Ascension Providence Rochester Hospital - Rochester
- Michigan Orthopaedic Surgeons, PLLC - Southfield
California
- Community Foundation Medical Group - Fresno
Colorado
- Cornerstone Orthopaedics & Sports Medicine - Superior
Kentucky
- Arthroplasty Foundation Inc. - Louisville
Minnesota
- TRIA Orthopaedic Center Research Institute - Bloomington
Missouri
- Thomas Aleto MD, PC - Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 380 participants |
| Start Date | 2021-06-14 |
| Est. Completion | 2027-12-31 |
What NCT04821154 shows while recruiting
NCT04821154 is an observational study that tracks outcomes without assigning an intervention. The registered 380 participants enrollment target is mid-sized for trials with a published cap, above the 301-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (26% higher).
The record links to 4 conditions, with Knee Osteoarthritis appearing as the primary indexed condition, and to 1 intervention - of which Persona Revision Knee System is the first listed.
NCT04821154 lists 16 locations in 13 states (Arkansas, Indiana, Michigan).
Frequently Asked Questions
What is clinical trial NCT04821154 about?
NCT04821154 is a clinical study titled "Persona Revision Knee System Outcomes". The study will evaluate the performance, clinical benefits and safety of the Persona Revision Knee System in patients who have received primary or revision total knee arthroplasty (TKA) treatment. This will be done using a multicenter, single-arm, consecutive series, retrospective cohort study with ...
What is the current status of trial NCT04821154?
This trial is currently recruiting. The enrollment target is 380 participants. The study started on 2021-06-14. Estimated completion is 2027-12-31.
What conditions does trial NCT04821154 study?
This clinical trial studies the following conditions: Knee Osteoarthritis, Infection, Arthroplasty Complications, Knee Disease.
What interventions are being tested in trial NCT04821154?
The interventions under investigation include: Persona Revision Knee System (DEVICE).
Who is sponsoring clinical trial NCT04821154?
This trial is sponsored by Zimmer Biomet, which has 115 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04821154 being conducted?
This trial has 16 study locations across Arkansas, California, Colorado, Indiana, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Knee Osteoarthritis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04821154's enrollment target sits among peer trials
380 12th of 101 higher than 90 of 101 other Knee Osteoarthritis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Knee Osteoarthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis
RECRUITING · NA
-
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
RECRUITING · NA
-
A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
RECRUITING · Early Phase 1
-
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
RECRUITING · Phase 4
-
Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
RECRUITING
-
Mechanical Alignment Vs Kalipered Kinematic Alignment Total Knee Arthroplasty
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04560673 · 380 participants · Phase 2
Duloxetine and Neurofeedback Training for the Treatment of Chemotherapy Induced Peripheral Neuropathy
- NCT04777357 · 380 participants · Phase 3
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
- NCT05102019 · 380 participants · NA
Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II
- NCT05511363 · 380 participants · Phase 3
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI