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NCT06906939 · ClinicalTrials.gov registry record · Early Phase 1

A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression

A Early Phase 1 study of Depression and Knee Osteoarthritis, sponsored by University of California, Los Angeles.

Recruiting
Registry status
Early Phase 1
Development phase
30
Enrollment target
1
Study location

NCT06906939: Recruiting Early Phase 1 study of Depression and Knee Osteoarthritis, sponsored by University of California, Los Angeles.

NCT06906939 is a Early Phase 1 study of Depression and Knee Osteoarthritis that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 30 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06906939, a Early Phase 1 study of Depression and Knee Osteoarthritis, is actively recruiting participants, sponsored by University of California, Los Angeles.

RECRUITING
Registry status
Early Phase 1
Development phase
30 participants
Enrollment target
1
Study location

Study Summary

Osteoarthritis (OA) is a major public health problem, and involvement of the knee is especially disabling. Symptomatic knee OA has an incidence rate between 40 to 1,020 per 100,000 person years1 and is among the most common causes of disability worldwide. Knee arthritis pain and disability are highly comorbid wiht depression (30-50%). Currently available treatments offer only limited relief. The Pilot project aims to establish feasibility of the rTMS neuromodulation of response to Tai Chi and improvement in pain and comorbid depression in patients with knee OA. There are several ways in which the pilot project will improve scientific knowledge, and clinical practice: 1) The sequential stimulation of two targets (M1 and l-DLPFC) has not been systematically examined for the treatment of comorbid MDD and knee OA. We hypothesize that using a multi-target rTMS strategy combining M1 and l-DLPFC- active targets will be well tolerated and more effective to treat comorbid symptoms than single site rTMS to M1+l-DLPFCsham. This hypothesis will be tested in Aim 1 of this proposal by comparing two experimental conditions: A) M1active and l-DLPFCactive; and B) M1active and l-DLPFCsham. 2) Identifying the relationship between improvement in pain and depression to improvement in pro-inflammatory cytokines would be novel. Adding an rTMS as a neuromodulation technique with novel stimulation sites to assist in the reduction of symptoms of pain and depression is another scalable to clinical use opportunity that will provide pilot data for future clinical trials. We will perform a pilot feasibility trial of rTMS for those presenting with knee osteoarthritis related pain and moderate to severe depression in 30 volunteers who are undergoing Tai Chi intervention. Tolerability and safety of rTMS added to Tai Chi will be assessed along with changes in symptoms of pain and depression, in preparation to future R-01 applications.

Primary Outcome

The number of sessions attended by each participant (attendance rate \>80% is considered feasible).

Conditions Studied

Depression Knee Osteoarthritis

Interventions

  • DEVICE repetetive transcranial magnetic stimulation

Study Locations (1)

California

  • UCLA Semel Institute - Neuropsychiatric Institute (NPI) - Los Angeles

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2026-04-01
Est. Completion 2029-06-30
Phase Early Phase 1
University of California, Los Angeles

897 total trials

What NCT06906939 shows while recruiting

NCT06906939 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (96% lower).

The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which repetetive transcranial magnetic stimulation is the first listed.

NCT06906939 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT06906939 about?

NCT06906939 is a clinical study titled "A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression". Osteoarthritis (OA) is a major public health problem, and involvement of the knee is especially disabling. Symptomatic knee OA has an incidence rate between 40 to 1,020 per 100,000 person years1 and is among the most common causes of disability worldwide. Knee arthritis pain and disability are highl...

What is the current status of trial NCT06906939?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 30 participants. The study started on 2026-04-01. Estimated completion is 2029-06-30.

What conditions does trial NCT06906939 study?

This clinical trial studies the following conditions: Depression, Knee Osteoarthritis.

What interventions are being tested in trial NCT06906939?

The interventions under investigation include: repetetive transcranial magnetic stimulation (DEVICE).

Who is sponsoring clinical trial NCT06906939?

This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06906939 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Depression

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06906939's enrollment target sits among peer trials

30 557th of 679 higher than 105 of 679 other Depression trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT06906939

Source: ClinicalTrials.gov NCT06906939, the US trial registry maintained by the National Library of Medicine. NCT06906939 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.