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ClinicalTrials.gov 47 recruiting now official registry

Metastatic Cancer clinical trials

47 of 117 indexed Metastatic Cancer trials are currently recruiting.

117 US clinical trials · 47 currently recruiting

Metastatic Cancer is the subject of 117 registered US clinical trials on ClinicalTrials.gov, 47 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 11 of these trials.

The research picture

Metastatic Cancer has 117 registered US clinical trials, 47 of them open to new participants right now, about 40% of the total.

47
recruiting participants now
40%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
11
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 154Phase 233Phase 38

Active & Recent Trials

117 total, page 1 of 3

RECRUITING 10,600 participants

Evaluating Disparities in Precision Oncology

Indiana University

NCT06081517

RECRUITING 2,000 participants

UNC Metastatic Cancer Radiation Therapy Registry

UNC Lineberger Comprehensive Cancer Center

NCT06306924

RECRUITING NA 1,000 participants

Longitudinal Screening for Financial Hardship to Improve Outcomes in Patients With Advanced Cancer

Alliance Foundation Trials

NCT06963723

RECRUITING Phase 1 575 participants

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Parabilis Medicines

NCT05919264

RECRUITING NA 500 participants

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

UNC Lineberger Comprehensive Cancer Center

NCT06896162

RECRUITING Phase 1 442 participants

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Artios Pharma

NCT04657068

RECRUITING NA 425 participants

A Study of the ApricityCare Program for Early Detection and Management of Treatment-Related Adverse Events in Patients With Cancer

M.D. Anderson Cancer Center

NCT06693687

RECRUITING Phase 1 332 participants

A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815

Jazz Pharmaceuticals

NCT05557045

RECRUITING Phase 1 330 participants

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

I-Mab Biopharma US Limited

NCT04900818

RECRUITING Phase 1 300 participants

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

PMV Pharmaceuticals

NCT04585750

RECRUITING 300 participants

Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry

Duke University

NCT04085029

RECRUITING Phase 1 278 participants

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

IDRx Inc. - A GSK Company

NCT05489237

RECRUITING Phase 1 264 participants

Comparing Dosing Intervals of Nivolumab or Pembrolizumab in Locally Advanced or Metastatic Cancers

University of Chicago

NCT04295863

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING Phase 2 200 participants

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

Mirati Therapeutics

NCT05853575

RECRUITING Phase 1 191 participants

Imaging of Solid Tumors Using FAP-2286

Thomas Hope

NCT04621435

RECRUITING Phase 2 180 participants

Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

I-Mab Biopharma US Limited

NCT07432295

RECRUITING Phase 1 168 participants

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

OncoResponse

NCT06090266

RECRUITING Phase 1 160 participants

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

CJ Bioscience

NCT05877430

RECRUITING Phase 1 159 participants

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Aulos Bioscience

NCT05267626

RECRUITING Phase 1 150 participants

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

Incyclix Bio

NCT05735080

RECRUITING Phase 1 130 participants

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

Qurient Co.

NCT05394103

RECRUITING Phase 1 124 participants

PRE-I-SPY Phase I/Ib Oncology Platform Program

QuantumLeap Healthcare Collaborative

NCT05868226

RECRUITING 114 participants

Prospective Validation of a Points Score System Predicting 30-day Survival

Indiana University

NCT05100342

RECRUITING Phase 1 110 participants

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

Alterome Therapeutics

NCT06533059

RECRUITING 104 participants

Optimizing Y90 Therapy for Radiation Lobectomy

Northwestern University

NCT04390724

RECRUITING Phase 1 90 participants

A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

Nectin Therapeutics

NCT05378425

RECRUITING Phase 1 60 participants

Y-NM600 in Patients Receiving Anti-PD-1 or Anti-PD-L1 for Metastatic Cancer

University of Wisconsin, Madison

NCT07197671

RECRUITING Phase 3 50 participants

A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s)

Daiichi Sankyo

NCT06174987

RECRUITING Phase 2 47 participants

Study of Cabozantinib and Nivolumab in Metastatic Castration Resistant Prostate Cancer

Rana McKay, MD

NCT05502315

RECRUITING Phase 1 46 participants

Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases

Baptist Health South Florida

NCT05789589

RECRUITING Phase 2 40 participants

A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change

Memorial Sloan Kettering Cancer Center

NCT05010031

RECRUITING Phase 1 40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Memgen

NCT05076760

RECRUITING Phase 1 40 participants

Molecularly Targeted Theranostic Approach for the Detection and Treatment of Metastatic Carcinomas

University of California, Davis

NCT06389123

RECRUITING Phase 2 40 participants

Triage of Advanced Cervical Cancer Through Immunotherapy Induction (TRACTION)

M.D. Anderson Cancer Center

NCT05475171

RECRUITING NA 38 participants

COBRA: Cancer, Older Adults, Balance and Resistance Activities

Memorial Sloan Kettering Cancer Center

NCT07011862

RECRUITING Phase 2 37 participants

Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors

University of Cincinnati

NCT06416007

RECRUITING Phase 2 30 participants

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Memorial Sloan Kettering Cancer Center

NCT06058988

RECRUITING NA 30 participants

Comparison of Whole Body DWI to FDG PET

University of California, San Francisco

NCT06630845

RECRUITING Phase 1 28 participants

STM-06: POLARIS-POlymetastic Lesion Ablative Radiotherapy With Immunotherapy Study

University of Illinois at Chicago

NCT07269080

RECRUITING Phase 2 26 participants

Definitive Radiation for High-Risk Spine Metastases

Stony Brook University

NCT06165419

RECRUITING Phase 1 26 participants

A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors

Proviva Therapeutics

NCT06190886

RECRUITING NA 24 participants

Palliative Spatially Fractionated (GRID) Radiotherapy Using Intensity Modulated Proton Therapy

Washington University School of Medicine

NCT05831579

RECRUITING Phase 2 20 participants

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Christian Hinrichs

NCT05686226

RECRUITING Phase 1 20 participants

Actinium 225 Labeled Anti-CEA Antibody (Ac225-DOTA-M5A) for the Treatment of CEA Producing Advanced or Metastatic Cancers

City of Hope Medical Center

NCT05204147

RECRUITING Phase 2 8 participants

Biomarkers to Detect Endocrine Therapy Resistance

University of Wisconsin, Madison

NCT06067503

RECRUITING Early Phase 1 4 participants

Using a PET Imaging Agent, 18F-Clofarabine (CFA), to Measure Deoxycytidine Kinase Activity in Metastatic Cancer

Roberto Vargas

NCT05065736

ACTIVE NOT RECRUITING Phase 1 731 participants

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Mirati Therapeutics

NCT03785249

ACTIVE NOT RECRUITING Phase 3 442 participants

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

Cogent Biosciences

NCT05208047

ACTIVE NOT RECRUITING Phase 2 309 participants

A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer

Eli Lilly and Company

NCT02711553

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Phase Distribution

PhaseTrial count
Phase 1 54
Phase 2 33
Phase 3 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Cancer Trial Landscape

117 indexed Metastatic Cancer studies · 47 recruiting (40%).

Phase mix: 8 late (III/IV) vs 87 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Cancer?

PlainTrial tracks 117 US clinical trials for Metastatic Cancer, of which 47 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.