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ClinicalTrials.gov 47 recruiting now official registry

Metastatic Cancer clinical trials

Every US clinical trial registered for Metastatic Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

117 US clinical trials · 47 currently recruiting

The research picture

Metastatic Cancer has 117 registered US clinical trials, 47 of them open to new participants right now — about 40% of the total.

47
recruiting participants now
40%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
11
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 10,600 participants

Evaluating Disparities in Precision Oncology

Indiana University

NCT06081517

RECRUITING 2,000 participants

UNC Metastatic Cancer Radiation Therapy Registry

UNC Lineberger Comprehensive Cancer Center

NCT06306924

RECRUITING NA 1,000 participants

Longitudinal Screening for Financial Hardship to Improve Outcomes in Patients With Advanced Cancer

Alliance Foundation Trials

NCT06963723

RECRUITING Phase 1 575 participants

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Parabilis Medicines

NCT05919264

RECRUITING NA 500 participants

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

UNC Lineberger Comprehensive Cancer Center

NCT06896162

RECRUITING Phase 1 442 participants

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Artios Pharma

NCT04657068

RECRUITING NA 425 participants

A Study of the ApricityCare Program for Early Detection and Management of Treatment-Related Adverse Events in Patients With Cancer

M.D. Anderson Cancer Center

NCT06693687

RECRUITING Phase 1 332 participants

A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815

Jazz Pharmaceuticals

NCT05557045

RECRUITING Phase 1 330 participants

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

I-Mab Biopharma US Limited

NCT04900818

RECRUITING Phase 1 300 participants

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

PMV Pharmaceuticals

NCT04585750

RECRUITING 300 participants

Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry

Duke University

NCT04085029

RECRUITING Phase 1 278 participants

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

IDRx Inc. - A GSK Company

NCT05489237

RECRUITING Phase 1 264 participants

Comparing Dosing Intervals of Nivolumab or Pembrolizumab in Locally Advanced or Metastatic Cancers

University of Chicago

NCT04295863

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING Phase 2 200 participants

Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

Mirati Therapeutics

NCT05853575

RECRUITING Phase 1 191 participants

Imaging of Solid Tumors Using FAP-2286

Thomas Hope

NCT04621435

RECRUITING Phase 2 180 participants

Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

I-Mab Biopharma US Limited

NCT07432295

RECRUITING Phase 1 168 participants

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

OncoResponse

NCT06090266

RECRUITING Phase 1 160 participants

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

CJ Bioscience

NCT05877430

RECRUITING Phase 1 159 participants

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Aulos Bioscience

NCT05267626

RECRUITING Phase 1 150 participants

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

Incyclix Bio

NCT05735080

RECRUITING Phase 1 130 participants

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

Qurient Co.

NCT05394103

RECRUITING Phase 1 124 participants

PRE-I-SPY Phase I/Ib Oncology Platform Program

QuantumLeap Healthcare Collaborative

NCT05868226

RECRUITING 114 participants

Prospective Validation of a Points Score System Predicting 30-day Survival

Indiana University

NCT05100342

RECRUITING Phase 1 110 participants

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

Alterome Therapeutics

NCT06533059

RECRUITING 104 participants

Optimizing Y90 Therapy for Radiation Lobectomy

Northwestern University

NCT04390724

RECRUITING Phase 1 90 participants

A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

Nectin Therapeutics

NCT05378425

RECRUITING Phase 1 60 participants

Y-NM600 in Patients Receiving Anti-PD-1 or Anti-PD-L1 for Metastatic Cancer

University of Wisconsin, Madison

NCT07197671

RECRUITING Phase 3 50 participants

A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s)

Daiichi Sankyo

NCT06174987

RECRUITING Phase 2 47 participants

Study of Cabozantinib and Nivolumab in Metastatic Castration Resistant Prostate Cancer

Rana McKay, MD

NCT05502315

RECRUITING Phase 1 46 participants

Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases

Baptist Health South Florida

NCT05789589

RECRUITING Phase 2 40 participants

A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change

Memorial Sloan Kettering Cancer Center

NCT05010031

RECRUITING Phase 1 40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Memgen

NCT05076760

RECRUITING Phase 1 40 participants

Molecularly Targeted Theranostic Approach for the Detection and Treatment of Metastatic Carcinomas

University of California, Davis

NCT06389123

RECRUITING Phase 2 40 participants

Triage of Advanced Cervical Cancer Through Immunotherapy Induction (TRACTION)

M.D. Anderson Cancer Center

NCT05475171

RECRUITING NA 38 participants

COBRA: Cancer, Older Adults, Balance and Resistance Activities

Memorial Sloan Kettering Cancer Center

NCT07011862

RECRUITING Phase 2 37 participants

Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors

University of Cincinnati

NCT06416007

RECRUITING Phase 2 30 participants

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Memorial Sloan Kettering Cancer Center

NCT06058988

RECRUITING NA 30 participants

Comparison of Whole Body DWI to FDG PET

University of California, San Francis

NCT06630845

RECRUITING Phase 1 28 participants

STM-06: POLARIS-POlymetastic Lesion Ablative Radiotherapy With Immunotherapy Study

University of Illinois at Chicago

NCT07269080

RECRUITING Phase 2 26 participants

Definitive Radiation for High-Risk Spine Metastases

Stony Brook University

NCT06165419

RECRUITING Phase 1 26 participants

A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors

Proviva Therapeutics

NCT06190886

RECRUITING NA 24 participants

Palliative Spatially Fractionated (GRID) Radiotherapy Using Intensity Modulated Proton Therapy

Washington University School of Medicine

NCT05831579

RECRUITING Phase 2 20 participants

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Christian Hinrichs

NCT05686226

RECRUITING Phase 1 20 participants

Actinium 225 Labeled Anti-CEA Antibody (Ac225-DOTA-M5A) for the Treatment of CEA Producing Advanced or Metastatic Cancers

City of Hope Medical Center

NCT05204147

RECRUITING Phase 2 8 participants

Biomarkers to Detect Endocrine Therapy Resistance

University of Wisconsin, Madison

NCT06067503

RECRUITING Early Phase 1 4 participants

Using a PET Imaging Agent, 18F-Clofarabine (CFA), to Measure Deoxycytidine Kinase Activity in Metastatic Cancer

Roberto Vargas

NCT05065736

ACTIVE NOT RECRUITING Phase 1 731 participants

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Mirati Therapeutics

NCT03785249

ACTIVE NOT RECRUITING Phase 3 442 participants

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

Cogent Biosciences

NCT05208047

ACTIVE NOT RECRUITING Phase 2 309 participants

A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer

Eli Lilly and Company

NCT02711553

ACTIVE NOT RECRUITING Phase 2 160 participants

Study of Osimertinib With and Without Ramucirumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Xiuning Le

NCT03909334

ACTIVE NOT RECRUITING Phase 2 120 participants

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Aadi Bioscience

NCT05103358

ACTIVE NOT RECRUITING Phase 1 85 participants

Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients

Verastem

NCT05375994

ACTIVE NOT RECRUITING Phase 1 82 participants

FS120 Phase 1/1b Study in Patients With Advanced Malignancies

invoX Pharma Limited

NCT04648202

ACTIVE NOT RECRUITING Phase 2 69 participants

A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors

Memorial Sloan Kettering Cancer Center

NCT03693014

ACTIVE NOT RECRUITING 69 participants

Biomarkers of Immune-Related Toxicity

University of Colorado, Denver

NCT03409016

ACTIVE NOT RECRUITING Phase 2 64 participants

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Memorial Sloan Kettering Cancer Center

NCT00492999

ACTIVE NOT RECRUITING Phase 2 60 participants

pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate Cancer

University of Wisconsin, Madison

NCT04090528

ACTIVE NOT RECRUITING Phase 1 54 participants

A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center

NCT05678010

ACTIVE NOT RECRUITING Phase 1 49 participants

A Study of RP-3500 in Combination With Standard Radiation Therapy in People With Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center

NCT05566574

ACTIVE NOT RECRUITING NA 45 participants

An Intervention to Help Patients and Caregivers Manage Stress and Improve Communication Skills When Talking About Cancer

Memorial Sloan Kettering Cancer Center

NCT03794635

ACTIVE NOT RECRUITING Phase 1 40 participants

Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer

Verastem

NCT05669482

ACTIVE NOT RECRUITING NA 39 participants

A Study of Stereotactic Body Radiotherapy (SBRT) and Surgical Stabilization for People With Cancer That Has Spread to the Bone

Memorial Sloan Kettering Cancer Center

NCT05038124

ACTIVE NOT RECRUITING Phase 2 35 participants

9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma

Glenn J. Hanna

NCT05010629

ACTIVE NOT RECRUITING Phase 2 32 participants

Metastatic Solid Cancer Clinical Trial

ImmunSYS

NCT04739618

ACTIVE NOT RECRUITING Phase 2 32 participants

A Phase 2 Trial for Patients With Metastatic Solid Cancer

Rampart Health, L.L.C.

NCT04713371

ACTIVE NOT RECRUITING NA 20 participants

Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer

City of Hope Medical Center

NCT02293954

ACTIVE NOT RECRUITING Phase 2 20 participants

Niraparib in Tumors Metastatic to the CNS

Massachusetts General Hospital

NCT04992013

ACTIVE NOT RECRUITING Phase 1 16 participants

QUILT-3.064: PD-L1 t-haNK In Subjects With Locally Advanced Or Metastatic Solid Cancers

ImmunityBio

NCT04050709

ACTIVE NOT RECRUITING Phase 1 12 participants

Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy

University of California, Irvine

NCT04868773

ACTIVE NOT RECRUITING Phase 2 10 participants

A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma

M.D. Anderson Cancer Center

NCT05335941

COMPLETED 22,517 participants

Study on Prevalence and Impact of Brain Metastases on Survival in Lung Cancer by Line of Treatment

Daiichi Sankyo

NCT06557967

COMPLETED Phase 3 600 participants

Zoledronate in Treating Patients With Solid Tumors That Have Spread to the Bone

Novartis

NCT00003884

COMPLETED Phase 3 501 participants

Talc in Treating Patients With Malignant Pleural Effusion

Alliance for Clinical Trials in Oncology

NCT00002622

COMPLETED NA 240 participants

Randomized Clinical Trial of a Multi-Modal Palliative Care Intervention

University of Colorado, Boulder

NCT04773639

COMPLETED Phase 3 213 participants

Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases

Alliance for Clinical Trials in Oncology

NCT00377156

COMPLETED Phase 1 174 participants

A Study of Evorpacept (ALX148) in Patients With Advanced Solid Tumors and Lymphoma (ASPEN-01)

ALX Oncology

NCT03013218

COMPLETED 137 participants

Quality of Life in Patients With Liver Cancer Treated With Image-Guided Therapy

Vanderbilt University

NCT00482586

COMPLETED Phase 3 135 participants

Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

Alliance for Clinical Trials in Oncology

NCT00002716

COMPLETED Phase 2 106 participants

Checkpoint Blockade Immunotherapy Combined With Stereotactic Body Radiation in Advanced Metastatic Disease

University of California, San Diego

NCT02843165

COMPLETED Phase 1 89 participants

Sym021 Monotherapy, in Combination With Sym022 or Sym023, and in Combination With Both Sym022 and Sym023 in Patients With Advanced Solid Tumor Malignancies or Lymphomas

Symphogen A/S

NCT03311412

COMPLETED Phase 1 78 participants

A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

Ikena Oncology

NCT04200963

COMPLETED 76 participants

Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders

Case Comprehensive Cancer Center

NCT00255671

COMPLETED Phase 2 59 participants

Heat Therapy in Treating Patients With Unresectable Primary or Metastatic Liver Cancer

M.D. Anderson Cancer Center

NCT00004136

COMPLETED NA 59 participants

Evaluation of Memory Skills in Patients Receiving Radiation Therapy for Brain Metastases

Radiation Therapy Oncology Group

NCT00007007

COMPLETED Phase 2 55 participants

Epothilone B in Treating Patients With CNS Metastases From Breast Cancer

David Peereboom, MD

NCT00450866

COMPLETED Phase 2 53 participants

Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer

University of Colorado, Denver

NCT03475004

COMPLETED Phase 2 49 participants

Inhaled Sargramostim in Treating Patients With First Pulmonary (Lung) Recurrence of Osteosarcoma

Children's Oncology Group

NCT00066365

COMPLETED Phase 2 44 participants

S0916, MLN1202 in Treating Patients With Bone Metastases

SWOG Cancer Research Network

NCT01015560

COMPLETED Phase 1 44 participants

LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors

PureTech

NCT04666688

COMPLETED NA 42 participants

Feasibility, Acceptability and Preliminary Effects of the Spiritual Care Assessment and Intervention

Indiana University

NCT03823313

COMPLETED Phase 1 41 participants

Lapatinib in Treating Patients With Advanced or Metastatic Breast Cancer That Overexpresses HER2

University of California, San Francis

NCT00544804

COMPLETED Phase 1 40 participants

Inhaled Sargramostim in Treating Patients With Melanoma Metastatic to the Lung

Alliance for Clinical Trials in Oncology

NCT00017121

COMPLETED Phase 2 35 participants

Stereotactic Body Radiation Therapy and Vertebroplasty in Treating Patients With Localized Spinal Metastasis

University of Texas Southwestern Medical Center

NCT00855803

COMPLETED Phase 1 30 participants

Heat Activated Liposomal Doxorubicin and Radiofrequency Ablation in Treating Patients With Primary or Metastatic Liver Tumors

National Institutes of Health Clinical Center (CC)

NCT00093444

COMPLETED Phase 2 30 participants

Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer

Jonsson Comprehensive Cancer Center

NCT00024076

COMPLETED Phase 1 28 participants

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer

Pediatric Brain Tumor Consortium

NCT00006246

COMPLETED Phase 2 27 participants

Bevacizumab in Pats w/ Recurrent ST Brain Metas Who Have Failed Whole Brain Radiation Therapy

Northwestern University

NCT01898130

COMPLETED Phase 1 26 participants

Radiation Therapy in Treating Patients With Liver Metastases

Radiation Therapy Oncology Group

NCT00255814

COMPLETED Phase 1 25 participants

Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment

City of Hope Medical Center

NCT00544284

Phase Distribution

PhaseTrial count
Phase 1 54
Phase 2 33
Phase 3 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Cancer Trial Landscape

ClinicalTrials.gov lists 117 US studies indexed under Metastatic Cancer, and 47 of those are currently open to recruitment — roughly 40% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Cancer shows 8 late-stage studies (Phase 3 and Phase 4 combined) alongside 87 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Cancer is led by Memorial Sloan Kettering Cancer Center with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Cancer?

PlainTrial tracks 117 US clinical trials for Metastatic Cancer, of which 47 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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