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ClinicalTrials.gov 23 recruiting now official registry

Attention Deficit Hyperactivity Disorder clinical trials

23 of 89 indexed Attention Deficit Hyperactivity Disorder trials are currently recruiting.

89 US clinical trials · 23 currently recruiting

Attention Deficit Hyperactivity Disorder is the subject of 89 registered US clinical trials on ClinicalTrials.gov, 23 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 8 of these trials.

The research picture

Attention Deficit Hyperactivity Disorder has 89 registered US clinical trials, 23 of them open to new participants right now, about 26% of the total.

23
recruiting participants now
26%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
8
top sponsor: Massachusetts General Hospital
Phase 17Phase 212Phase 37Phase 414

Active & Recent Trials

89 total, page 1 of 2

RECRUITING 1,100 participants

Developing Brain, Impulsivity and Compulsivity

National Institute of Mental Health (NIMH)

NCT04631042

RECRUITING NA 600 participants

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Massachusetts General Hospital

NCT04296604

RECRUITING NA 500 participants

Neurocognitive Effects of Non-Invasive Near-Infrared Light Stimulation

University of Texas at Austin

NCT05802680

RECRUITING Phase 4 500 participants

Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD

Icahn School of Medicine at Mount Sinai

NCT03781752

RECRUITING NA 316 participants

BUILT Family Lifestyle Program for Children with ADHD

University of Illinois at Chicago

NCT05464056

RECRUITING NA 300 participants

Interventions for English Language Learners At-Risk for ADHD

Florida International University

NCT05918991

RECRUITING NA 280 participants

Efficacy of Trigeminal Nerve Stimulation for ADHD

University of California, Los Angeles

NCT05374187

RECRUITING Phase 4 252 participants

R61/33 - VR Study Phase 4

Rutgers, The State University of New Jersey

NCT07169760

RECRUITING NA 240 participants

HOPS Study: A Conceptual Replication

Children's Hospital of Philadelphia

NCT04465708

RECRUITING Phase 1 219 participants

Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial

National Institute of Mental Health (NIMH)

NCT05608434

RECRUITING NA 180 participants

Project PEAK: Early Intervention for ADHD

Lehigh University

NCT04627415

RECRUITING NA 145 participants

Motor Attention Training for Attention Deficit Hyperactivity Disorder (ADHD)

University of Wisconsin, Madison

NCT02688959

RECRUITING NA 144 participants

Enhancing Team Effectiveness for a Collaborative School-based Intervention for ADHD

University of California, San Diego

NCT06180681

RECRUITING NA 100 participants

Mindfulness Intervention for College Students With ADHD

University of Alabama, Tuscaloo

NCT06076967

RECRUITING Phase 2 62 participants

COMT Inhibition Among Individuals With Comorbid AUD/ADHD

University of Colorado, Denver

NCT03904498

RECRUITING Phase 4 50 participants

A Trial of Dyanavel XR in Treating Co-occurring Fatigue Symptoms in Adults With Attention Deficit Hyperactivity Disorder (ADHD).

Rochester Center for Behavioral Medicine

NCT06248229

RECRUITING NA 50 participants

Optimizing Attention and Sleep Intervention Study

University of Pittsburgh

NCT05683756

RECRUITING NA 48 participants

Acute Effects of Exercise in College Students With ADHD

University of Wyoming

NCT03666416

RECRUITING Phase 4 44 participants

Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Icahn School of Medicine at Mount Sinai

NCT03781765

RECRUITING NA 40 participants

ADHD PreSMA Response Inhibition Therapy

Children's Hospital Medical Center, Cincinnati

NCT06325813

RECRUITING Phase 2 40 participants

Acute Effects of Stimulant Medication in College Students With ADHD

University of Wyoming

NCT03935646

RECRUITING NA 30 participants

Trigeminal Nerve Stimulation for Children With Prenatal Alcohol Exposure

University of California, Los Angeles

NCT06847165

RECRUITING Phase 4 10 participants

Stimulant Effects on Disruptive Behavior

Matthew J O'Brien, PhD, BCBA-D

NCT03420339

ACTIVE NOT RECRUITING 4,274 participants

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

National Institute of Mental Health (NIMH)

NCT00001246

ACTIVE NOT RECRUITING NA 250 participants

Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals

Massachusetts General Hospital

NCT01075672

ACTIVE NOT RECRUITING NA 108 participants

Family Navigation to Improve ADHD Treatment Adherence for Minority Children

Children's Hospital Medical Center, Cincinnati

NCT04591951

ACTIVE NOT RECRUITING NA 104 participants

A Dose-Response Study of the Cognitive and Physiological Effects of tDCS to the DLPFC

Massachusetts General Hospital

NCT04175041

ACTIVE NOT RECRUITING NA 30 participants

Personalized Attention-Deficit/Hyperactivity Disorder (ADHD) Medication Experiment Study

Children's Hospital Medical Center, Cincinnati

NCT06305078

ACTIVE NOT RECRUITING NA 30 participants

Settling Down for Sleep in ADHD: The Impact of Sensory and Arousal Systems on Sleep in ADHD

University of Pittsburgh

NCT06406309

COMPLETED NA 895 participants

Educating and Supporting Primary Care Providers in the Implementation of Evidence-based Practices for ADHD

Children's Hospital of Philadelphia

NCT02271386

COMPLETED Phase 2 740 participants

Study of the Safety and Efficacy of OPC-34712 as a Complementary Therapy in the Treatment of Adult Attention Deficit/Hyperactivity Disorder

Otsuka Pharmaceutical Development & Commercialization

NCT01074294

COMPLETED Phase 4 445 participants

Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) With Atomoxetine in Young Adults and Its Effects on Functional Outcomes

Eli Lilly and Company

NCT00510276

COMPLETED Phase 3 420 participants

Study to Assess the Safety and Efficacy of NRP104 in Adults With Attention-Deficit Hyperactivity Disorder (ADHD)

New River Pharmaceuticals

NCT00334880

COMPLETED Phase 2 370 participants

Dose-Finding Study to Evaluate the Efficacy and Safety of Modafinil as Treatment for Adults With ADHD

Cephalon

NCT00315276

COMPLETED Phase 2 340 participants

A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder

Eli Lilly and Company

NCT00922636

COMPLETED Phase 3 320 participants

Adult Attention Deficit Hyperactivity Disorder (ADHD) Study With Amphetamine Sulfate

Arbor Pharmaceuticals

NCT03659929

COMPLETED 312 participants

Adolescent Changes in Brain and Behavior in Boys and Girls With ADHD

Hugo W. Moser Research Institute at Kennedy Krieger

NCT05927506

COMPLETED Phase 3 304 participants

Long Term Safety Study of Study Drug (Eszopiclone) in Children and Adolescents With ADHD -Associated Insomnia

Sumitomo Pharma America

NCT00857220

COMPLETED NA 278 participants

STAND Community Trial

Florida International University

NCT02694939

COMPLETED 258 participants

Neurophysiological Attention Test (NAT) for Objective Assessment of Adult ADHD

Think Now Incorporated

NCT02756286

COMPLETED Phase 3 230 participants

Efficacy and Safety of Methylphenidate HCl ER Capsules in Children and Adolescents With ADHD

Rhodes Pharmaceuticals, L.P.

NCT01239030

COMPLETED Phase 2 227 participants

Investigating the Effect of Vortioxetine in Adult ADHD Patients

H. Lundbeck A/S

NCT02327013

COMPLETED NA 211 participants

Enhancing IEPs of Children With ADHD Using Daily Report Cards

State University of New York at Buffalo

NCT03747887

COMPLETED NA 206 participants

Software Treatment for Actively Reducing Severity of ADHD as Adjunctive Treatment to Stimulant

Akili Interactive Labs

NCT03649074

COMPLETED NA 187 participants

Parent Training for Attention Deficit Hyperactivity Disorder (ADHD) Preschoolers

NYU Langone Health

NCT01320098

COMPLETED NA 186 participants

Multisite Study of High School-based Treatment for Adolescents With ADHD

Ohio University

NCT04480346

COMPLETED Phase 2 141 participants

A Safety and Tolerability Study of ABT-089 in Adults With Attention Deficit-Hyperactivity Disorder (ADHD)

AbbVie (prior sponsor, Abbott)

NCT00443391

COMPLETED Phase 3 125 participants

A Pivotal Efficacy Trial to Evaluate HLD200 in Children With ADHD in a Classroom Setting

Ironshore Pharmaceuticals and Development

NCT02493777

COMPLETED Phase 3 120 participants

Study to Evaluate the Efficacy of Modafinil Treatment in Patients With Attention Deficit Hyperactivity Disorder (ADHD) Who Are Responders to Modafinil Treatment

Cephalon

NCT00343811

COMPLETED NA 117 participants

Imaging the Effects of Stimulant Medication on Emotional Lability in Patients With ADHD

New York State Psychiatric Institute

NCT01415440

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 12
Phase 3 7
Phase 4 14

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Attention Deficit Hyperactivity Disorder Trial Landscape

89 indexed Attention Deficit Hyperactivity Disorder studies · 23 recruiting (26%).

Phase mix: 21 late (III/IV) vs 19 early (I/II).

Top sponsor: Massachusetts General Hospital (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Attention Deficit Hyperactivity Disorder?

PlainTrial tracks 89 US clinical trials for Attention Deficit Hyperactivity Disorder, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Attention Deficit Hyperactivity Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.