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2026 data Public-data reference. official source

Attention Deficit Hyperactivity Disorder

Open-data reference.

86 US clinical trials · 21 currently recruiting

Active & Recent Trials

RECRUITING 1,100 participants

Developing Brain, Impulsivity and Compulsivity

National Institute of Mental Health (NIMH)

NCT04631042

RECRUITING NA 600 participants

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Massachusetts General Hospital

NCT04296604

RECRUITING NA 500 participants

Neurocognitive Effects of Non-Invasive Near-Infrared Light Stimulation

University of Texas at Austin

NCT05802680

RECRUITING Phase 4 500 participants

Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD

Icahn School of Medicine at Mount Sinai

NCT03781752

RECRUITING NA 316 participants

BUILT Family Lifestyle Program for Children with ADHD

University of Illinois at Chicago

NCT05464056

RECRUITING NA 300 participants

Interventions for English Language Learners At-Risk for ADHD

Florida International University

NCT05918991

RECRUITING Phase 4 252 participants

R61/33 - VR Study Phase 4

Rutgers, The State University of New Jersey

NCT07169760

RECRUITING NA 240 participants

HOPS Study: A Conceptual Replication

Children's Hospital of Philadelphia

NCT04465708

RECRUITING Phase 1 219 participants

Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial

National Institute of Mental Health (NIMH)

NCT05608434

RECRUITING NA 180 participants

Project PEAK: Early Intervention for ADHD

Lehigh University

NCT04627415

RECRUITING NA 145 participants

Motor Attention Training for Attention Deficit Hyperactivity Disorder (ADHD)

University of Wisconsin, Madison

NCT02688959

RECRUITING NA 100 participants

Mindfulness Intervention for College Students With ADHD

University of Alabama, Tuscaloo

NCT06076967

RECRUITING Phase 2 62 participants

COMT Inhibition Among Individuals With Comorbid AUD/ADHD

University of Colorado, Denver

NCT03904498

RECRUITING Phase 4 50 participants

A Trial of Dyanavel XR in Treating Co-occurring Fatigue Symptoms in Adults With Attention Deficit Hyperactivity Disorder (ADHD).

Rochester Center for Behavioral Medicine

NCT06248229

RECRUITING NA 50 participants

Optimizing Attention and Sleep Intervention Study

University of Pittsburgh

NCT05683756

RECRUITING NA 48 participants

Acute Effects of Exercise in College Students With ADHD

University of Wyoming

NCT03666416

RECRUITING Phase 4 44 participants

Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Icahn School of Medicine at Mount Sinai

NCT03781765

RECRUITING NA 40 participants

ADHD PreSMA Response Inhibition Therapy

Children's Hospital Medical Center, Cincinnati

NCT06325813

RECRUITING Phase 2 40 participants

Acute Effects of Stimulant Medication in College Students With ADHD

University of Wyoming

NCT03935646

RECRUITING NA 30 participants

Trigeminal Nerve Stimulation for Children With Prenatal Alcohol Exposure

University of California, Los Angeles

NCT06847165

RECRUITING Phase 4 10 participants

Stimulant Effects on Disruptive Behavior

Matthew J O'Brien, PhD, BCBA-D

NCT03420339

ACTIVE NOT RECRUITING 4,274 participants

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

National Institute of Mental Health (NIMH)

NCT00001246

ACTIVE NOT RECRUITING NA 250 participants

Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals

Massachusetts General Hospital

NCT01075672

ACTIVE NOT RECRUITING NA 108 participants

Family Navigation to Improve ADHD Treatment Adherence for Minority Children

Children's Hospital Medical Center, Cincinnati

NCT04591951

ACTIVE NOT RECRUITING NA 104 participants

A Dose-Response Study of the Cognitive and Physiological Effects of tDCS to the DLPFC

Massachusetts General Hospital

NCT04175041

ACTIVE NOT RECRUITING NA 30 participants

Personalized Attention-Deficit/Hyperactivity Disorder (ADHD) Medication Experiment Study

Children's Hospital Medical Center, Cincinnati

NCT06305078

ACTIVE NOT RECRUITING NA 30 participants

Settling Down for Sleep in ADHD: The Impact of Sensory and Arousal Systems on Sleep in ADHD

University of Pittsburgh

NCT06406309

COMPLETED NA 895 participants

Educating and Supporting Primary Care Providers in the Implementation of Evidence-based Practices for ADHD

Children's Hospital of Philadelphia

NCT02271386

COMPLETED Phase 2 740 participants

Study of the Safety and Efficacy of OPC-34712 as a Complementary Therapy in the Treatment of Adult Attention Deficit/Hyperactivity Disorder

Otsuka Pharmaceutical Development & Commercialization

NCT01074294

COMPLETED Phase 4 445 participants

Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) With Atomoxetine in Young Adults and Its Effects on Functional Outcomes

Eli Lilly and Company

NCT00510276

COMPLETED Phase 3 420 participants

Study to Assess the Safety and Efficacy of NRP104 in Adults With Attention-Deficit Hyperactivity Disorder (ADHD)

New River Pharmaceuticals

NCT00334880

COMPLETED Phase 2 370 participants

Dose-Finding Study to Evaluate the Efficacy and Safety of Modafinil as Treatment for Adults With ADHD

Cephalon

NCT00315276

COMPLETED Phase 2 340 participants

A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder

Eli Lilly and Company

NCT00922636

COMPLETED Phase 3 320 participants

Adult Attention Deficit Hyperactivity Disorder (ADHD) Study With Amphetamine Sulfate

Arbor Pharmaceuticals

NCT03659929

COMPLETED 312 participants

Adolescent Changes in Brain and Behavior in Boys and Girls With ADHD

Hugo W. Moser Research Institute at Kennedy Krieger

NCT05927506

COMPLETED Phase 3 304 participants

Long Term Safety Study of Study Drug (Eszopiclone) in Children and Adolescents With ADHD -Associated Insomnia

Sumitomo Pharma America

NCT00857220

COMPLETED NA 278 participants

STAND Community Trial

Florida International University

NCT02694939

COMPLETED 258 participants

Neurophysiological Attention Test (NAT) for Objective Assessment of Adult ADHD

Think Now Incorporated

NCT02756286

COMPLETED Phase 3 230 participants

Efficacy and Safety of Methylphenidate HCl ER Capsules in Children and Adolescents With ADHD

Rhodes Pharmaceuticals, L.P.

NCT01239030

COMPLETED Phase 2 227 participants

Investigating the Effect of Vortioxetine in Adult ADHD Patients

H. Lundbeck A/S

NCT02327013

COMPLETED NA 211 participants

Enhancing IEPs of Children With ADHD Using Daily Report Cards

State University of New York at Buffalo

NCT03747887

COMPLETED NA 206 participants

Software Treatment for Actively Reducing Severity of ADHD as Adjunctive Treatment to Stimulant

Akili Interactive Labs

NCT03649074

COMPLETED NA 187 participants

Parent Training for Attention Deficit Hyperactivity Disorder (ADHD) Preschoolers

NYU Langone Health

NCT01320098

COMPLETED NA 186 participants

Multisite Study of High School-based Treatment for Adolescents With ADHD

Ohio University

NCT04480346

COMPLETED Phase 2 141 participants

A Safety and Tolerability Study of ABT-089 in Adults With Attention Deficit-Hyperactivity Disorder (ADHD)

AbbVie (prior sponsor, Abbott)

NCT00443391

COMPLETED Phase 3 125 participants

A Pivotal Efficacy Trial to Evaluate HLD200 in Children With ADHD in a Classroom Setting

Ironshore Pharmaceuticals and Development

NCT02493777

COMPLETED Phase 3 120 participants

Study to Evaluate the Efficacy of Modafinil Treatment in Patients With Attention Deficit Hyperactivity Disorder (ADHD) Who Are Responders to Modafinil Treatment

Cephalon

NCT00343811

COMPLETED NA 117 participants

Imaging the Effects of Stimulant Medication on Emotional Lability in Patients With ADHD

New York State Psychiatric Institute

NCT01415440

COMPLETED NA 113 participants

Helping College Students With ADHD Lead Healthier Lifestyles

University of Maryland, College Park

NCT02829970

COMPLETED Phase 4 105 participants

Bupropion for ADHD in Adolescents With Substance Use Disorder

University of Colorado, Denver

NCT00936299

COMPLETED NA 85 participants

New Technologies to Help Manage ADHD

Children's Hospital Medical Center, Cincinnati

NCT02390791

COMPLETED NA 84 participants

Cognitive ADHD Videogame Exploratory Study

Akili Interactive Labs

NCT01943539

COMPLETED NA 73 participants

dHealth Solution for Improving Parent Adherence to Behavioral Treatment for ADHD

University of California, San Francis

NCT04025814

COMPLETED Phase 4 71 participants

Diagnostic Utility of Attention Deficit Hyperactivity Disorder (ADHD) by Brain Activity Flow Patterns Analysis Using Evoked Response Potentials

Massachusetts General Hospital

NCT01063153

COMPLETED NA 70 participants

Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder

Denver Health and Hospital Authority

NCT00399763

COMPLETED Phase 2 69 participants

PART A: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and With mGluR Mutations

Aevi Genomic Medicine, LLC, a Cerecor company

NCT03265119

COMPLETED Early Phase 1 68 participants

Mindfulness-Based ADHD Treatment for Children: a Feasibility Study

Yale University

NCT04737512

COMPLETED Phase 4 62 participants

A Within-Subject Cross-Over Comparison Between Immediate Release and Extended Release Adderall

NYU Langone Health

NCT00468143

COMPLETED Phase 4 62 participants

Safety and Efficacy of Switching From a Stimulant Medication to Atomoxetine in Children and Adolescents With ADHD

Eli Lilly and Company

NCT00485875

COMPLETED NA 59 participants

Brain Plasticity Underlying Acquisition of New Organizational Skills in Children

NYU Langone Health

NCT04108273

COMPLETED Phase 4 50 participants

Naturalistic Substitution of Concerta in Adult Subject With ADHD Receiving Immediate Release Methylphenidate

Massachusetts General Hospital

NCT00302406

COMPLETED NA 44 participants

Mindful Parenting and Parent Training Program Study

New York University

NCT03796663

COMPLETED NA 42 participants

Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase

NYU Langone Health

NCT03148782

COMPLETED Early Phase 1 40 participants

Eye Tracking as a Predictor of Methylphenidate Response in Autism With ADHD

Children's Hospital Medical Center, Cincinnati

NCT02874690

COMPLETED Phase 4 40 participants

Effectiveness and Duration of Effect of Open Treatment in Attention Deficit Hyperactivity Disorder (ADHD) Patients Treated With Lisdexamfetamine Dimesylate(Vyvanse)

NYU Langone Health

NCT01070394

COMPLETED NA 40 participants

A SMART Design to Improve Sleep Disturbance in Adolescents With Neurodevelopmental Disorders

University of Nebraska

NCT03730194

COMPLETED 38 participants

Attention-Deficit/Hyperactivity Disorder (ADHD) Brain Activity Changes to Psychostimulants

Hartford Hospital

NCT01310439

COMPLETED NA 38 participants

Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD

Massachusetts General Hospital

NCT04569058

COMPLETED Phase 2 38 participants

Shire SCT: Lisdexamfetamine Treatment for ADHD and SCT

NYU Langone Health

NCT02635035

COMPLETED Phase 4 36 participants

Study of Medication Patch to Treat Children Ages 6-12 With ADHD

Massachusetts General Hospital

NCT00586157

COMPLETED NA 35 participants

Text Messaging Adherence to Stimulant Medication

Massachusetts General Hospital

NCT01967485

COMPLETED NA 34 participants

Mobile Behavioral Parent Training for Childhood ADHD: A Micro-randomized Trial

Florida International University

NCT06012851

COMPLETED Phase 2 32 participants

A Safety and Effectiveness Study of JNJ-31001074 in Adults With Attention-Deficit/Hyperactivity Disorder.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

NCT00566449

COMPLETED Phase 2 30 participants

Preschool Supplement to Clonidine in ADHD (Kiddie-CAT)

University of Cincinnati

NCT00414921

COMPLETED Phase 4 30 participants

Study of the Effects of Osmotic-Release Oral System (OROS) Methylphenidate (Concerta) on Attention and Memory

Children's Hospital of Philadelphia

NCT00530257

COMPLETED NA 28 participants

Electroencephalogram (EEG) Study of Inattention Following Treatment With AKL-T01

Akili Interactive Labs

NCT03844269

COMPLETED Phase 1 28 participants

Task-Based Grounding Program

Dartmouth-Hitchcock Medical Center

NCT04648553

COMPLETED NA 28 participants

Effects of Exercise Intensity on ADHD Symptoms

Kent State University

NCT06753253

COMPLETED NA 22 participants

Effectiveness Study of Videoconferencing on Teaching Parent Training Skills to Parents of Children With Attention Deficit Hyperactivity Disorder (ADHD)

University of California, Davis

NCT01161719

COMPLETED NA 21 participants

GroundsKeeper: A Qualitative Study of Applied Game-based Interactives in Special Education Programs

CogCubed

NCT01808066

COMPLETED Phase 2 20 participants

Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa

Chelsea Therapeutics

NCT00983814

COMPLETED NA 18 participants

Predictive Executive Functioning Models Using Interactive Tangible-Graphical Interface Devices in Adults

CogCubed

NCT02127931

COMPLETED Phase 3 16 participants

A Pilot Study of Daytrana TM in Children With Autism Co-Morbid for Attention Deficit Hyperactivity Disorder (ADHD) Symptoms

University of Oklahoma

NCT00541346

COMPLETED Phase 1 14 participants

Medication Integration in Treatment of Comorbid Adolescent Substance Users/Attention Deficit Hyperactivity Disorder

The National Center on Addiction and Substance Abuse at Columbia University

NCT01369459

COMPLETED NA 12 participants

Healing Minds: Biofeedback and Breathing Practices in Children and Adolescents With ADHD

Hoskinson Health and Wellness Clinic

NCT06648252

COMPLETED Early Phase 1 6 participants

Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity Disorder

Texas Tech University

NCT03533556

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 12
Phase 3 7
Phase 4 14

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Attention Deficit Hyperactivity Disorder Trial Landscape

ClinicalTrials.gov lists 86 US studies indexed under Attention Deficit Hyperactivity Disorder, and 21 of those are currently open to recruitment — roughly 24% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Attention Deficit Hyperactivity Disorder shows 21 late-stage studies (Phase 3 and Phase 4 combined) alongside 18 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Attention Deficit Hyperactivity Disorder is led by Massachusetts General Hospital with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 86 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Attention Deficit Hyperactivity Disorder?

PlainTrial tracks 86 US clinical trials for Attention Deficit Hyperactivity Disorder, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Attention Deficit Hyperactivity Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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