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NCT06859164 · ClinicalTrials.gov registry record · Phase 2
Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
A Phase 2 study of Knee Osteoarthritis and Knee Osteoarthritis (OA), sponsored by University of Chicago.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06859164: Recruiting Phase 2 study of Knee Osteoarthritis and Knee Osteoarthritis (OA), sponsored by University of Chicago.
NCT06859164 is a Phase 2 study of Knee Osteoarthritis and Knee Osteoarthritis (OA) that is actively recruiting participants, run by University of Chicago. The registered enrollment target is 50 participants, below the 304-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06859164, a Phase 2 study of Knee Osteoarthritis and Knee Osteoarthritis (OA), is actively recruiting participants, sponsored by University of Chicago.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-related pain at 3 months as measured by the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscore. Additionally, this study aims to determine the magnitude of difference in pain response between GAE and sham to adequately power a larger, more definitive randomized sham-controlled trial (RCT). The influence of psychosocial and psychocognitive factors, changes in analgesic use, and conditions of knee joint cartilage and effusion will similarly be explored to determine their impacts on perceived pain response to GAE.
Primary Outcome
Percent change in KOOS pain subscale score, scaled to a range of 0-100, from baseline to 3 months post-randomization of both GAE and sham groups.
Conditions Studied
Interventions
- DEVICE Lipiodol
- PROCEDURE Genicular Artery Embolization
- PROCEDURE Simple angiogram
Study Locations (1)
Illinois
- University of Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2026-11-30 |
| Phase | Phase 2 |
What NCT06859164 shows while recruiting
NCT06859164 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 304-participant average among 101 other Knee Osteoarthritis trials with a reported enrollment target (84% lower).
The record links to 3 conditions, with Knee Osteoarthritis appearing as the primary indexed condition, and to 3 interventions - of which Lipiodol is the first listed.
NCT06859164 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06859164 about?
NCT06859164 is a clinical study titled "Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis". Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-rela...
What is the current status of trial NCT06859164?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2025-05-01. Estimated completion is 2026-11-30.
What conditions does trial NCT06859164 study?
This clinical trial studies the following conditions: Knee Osteoarthritis, Knee Osteoarthritis (OA), Knee Osteoarthritis (Knee OA).
What interventions are being tested in trial NCT06859164?
The interventions under investigation include: Lipiodol (DEVICE), Genicular Artery Embolization (PROCEDURE), Simple angiogram (PROCEDURE).
Who is sponsoring clinical trial NCT06859164?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06859164 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Knee Osteoarthritis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06859164's enrollment target sits among peer trials
50 70th of 101 higher than 32 of 101 other Knee Osteoarthritis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Knee Osteoarthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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