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Knee Osteoarthritis: full-pipeline trial registry
41 of 102 indexed Knee Osteoarthritis trials are currently recruiting.
Corpus placement: #134 of 28,707 conditions by registered trial count.
102 US clinical trials · 41 currently recruiting · #134 of 28,707 conditions by registered trial count
Knee Osteoarthritis: 102 US clinical trials tracked, 41 recruiting.
Knee Osteoarthritis is the subject of 102 registered US clinical trials on ClinicalTrials.gov, 41 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Northwestern University, running 3 of these trials.
Enrollment posture brief
Registry condition knee-osteoarthritis
OPEN 41 | RECR 40% | LATE 14 | EARLY 17 | RANK #134 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Metastatic Cancer (40% recruiting · 117 trials)
Knee Osteoarthritis lists 41 open slots (40% of 102 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Knee Osteoarthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Knee Osteoarthritis is recruiting above its size-band peers.
41 of 102 indexed trials (40.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Knee Osteoarthritis trials is spread across many organizations.
Northwestern University accounts for 3 of 102 trials (2.9%). 77 distinct sponsors appear on at least one study for this condition label.
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Typical Knee Osteoarthritis enrolment sits around 83 participants.
Median target enrolment is 83 among the 102 trials that report a genuine target (sentinel values excluded). 56 of those (54.9%) plan for fewer than 100 participants.
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Knee Osteoarthritis research is mostly interventional.
88 interventional and 14 observational studies make up this index (86.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
102 total, page 2 of 3
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
Genascence Corporation
NCT05835895
Impact of Different Exercise Programs on Knee OA
Shirley Ryan AbilityLab
NCT05844124
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
Campbell Clinic
NCT05099276
A Powered Exoskeleton for Veterans With Knee OA
VA Office of Research and Development
NCT04653896
Blood-Flow Restriction Exercise Following a Knee Replacement
Michigan Technological University
NCT04018638
Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain
Kenneth B Chapman
NCT05103527
Telehealth Stepped Exercise Program for Rural Veterans With Knee Osteoarthritis
Durham VA Medical Center
NCT04775589
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
University Hospitals Cleveland Medical Center
NCT03477942
Osteoarthritis Initiative (OAI): A Knee Health Study
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00080171
A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS
Restor3D
NCT03152357
Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
Organogenesis
NCT04636229
Patient-Reported Outcomes in Evaluating Lorecivivint (SM04690) for Moderate to Severe Knee Osteoarthritis (STRIDES-1)
Biosplice Therapeutics
NCT04385303
Micronized dHACM vs. Saline in the Treatment of Osteoarthritis of the Knee
MiMedx Group
NCT03485157
Safety/Efficacy of Balicatib (AAE581) in Adults With Osteoarthritis of the Knee
Novartis Pharmaceuticals
NCT00371670
The Effects of Specialized Footwear in Osteoarthritis
Rush University Medical Center
NCT01597830
Effectiveness of BREG Flex in 12-week Peri-operative Total Knee Arthroplasty
The Hawkins Foundation
NCT03840096
Microfragmented Adipose Tissue Compared to Corticosteroid Injection for the Treatment of Knee Osteoarthritis
Lipogems International spa
NCT05660772
Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
Pacira Pharmaceuticals
NCT05139030
Evaluation of a Home-based NMES Therapy for Knee Osteoarthritis Pain
CyMedica Orthopedics
NCT04128618
A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
OrthoTrophix
NCT01925261
Shared Decision Making in Patients With Osteoarthritis of the Hip and Knee
University of California, San Francisco
NCT01492257
Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain
University of Pittsburgh
NCT05003323
Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis
Andrews Research & Education Foundation
NCT03289416
Yoga Versus Exercises for Managing OA
University of Minnesota
NCT02525341
Vibratory Stimuli, A Novel Rehabilitation Method for Preventing Post - Traumatic Knee Osteoarthritis
University of North Carolina, Chapel Hill
NCT02605876
The Effect of Intra-articular Bilateral Knee Injections of Zilretta on Performance Measures in Adults With Knee OA
University of Kansas Medical Center
NCT03895840
Development of a Mind Body Program for Obese Knee Osteoarthritis Patients With Comorbid Depression
University of Kentucky
NCT04334278
Evaluation of NMES Therapy for Pain Relief Associated With Knee Osteoarthritis
CyMedica Orthopedics
NCT04367597
Ultrasound Guided Knee Injections in Musculoskeletal Medicine
Andrews Research & Education Foundation
NCT03293238
Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain
ZetrOZ
NCT05050448
A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.
Maurizio Fava, MD
NCT05025787
The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis
Brigham and Women's Hospital
NCT01383954
Gold Factor on Knee Joint Health and Function
4Life Research
NCT05347602
Regenexx™ SD Versus Exercise Therapy for Treatment of Knee Osteoarthritis With Historical Comparison to TKA
Regenexx
NCT02034032
Intraarticular Dextrose Prolotherapy for Symptomatic Knee Osteoarthritis
Mayo Clinic
NCT05160532
Tai Chi Mind-Body Therapy for Knee Osteoarthritis
Tufts Medical Center
NCT00362453
Efficacy of Celecoxib vs Placebo to Prevent Pain in a Paced Walk
University Hospitals Cleveland Medical Center
NCT00194090
Shoe Modification and Knee Osteoarthritis
VA Office of Research and Development
NCT00105365
KAATSU Training to Enhance Physical Function of Older Adults With Osteoarthritis
University of Florida
NCT02132715
Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis
University of Texas, El Paso
NCT05625178
Strengthening Exercise and Quadriceps Force During Walking
Frederiksberg University Hospital
NCT01538407
Intra-articular Pulsed Radiofrequency Neuromodulation Versus Intra-articular Steroids for Painful Knee Osteoarthritis
Center For Interventional Pain and Spine
NCT04238598
Effects of Bracing on Knee Osteoarthritis (OA)
Stony Brook University
NCT01886144
Self Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis
The University of Texas Health Science Center, Houston
NCT03425019
Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis
Mayo Clinic
NCT06329492
Investigating Racial Differences in Diet Benefits for Knee Osteoarthritis
University of Alabama at Birmingham
NCT04343716
A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis
Centrexion Therapeutics
NCT03576508
Blood Flow Restriction Training in Individuals Awaiting Total Knee Replacement
The University of Texas Health Science Center at San Antonio
NCT06111690
Influence of Noxious Electrical Stimulation on Chronic Pain From Knee Osteoarthritis
University of New England
NCT04628013
To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection
University of California, San Francisco
NCT01895959
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 8 |
| Phase 2 | 9 |
| Phase 3 | 6 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Knee Osteoarthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Knee Osteoarthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Knee Osteoarthritis page
102 registered trials, 41 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 41 Knee Osteoarthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Northwestern University sponsors the most Knee Osteoarthritis trials on record, review their full trial history before evaluating a specific study. See Northwestern University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Knee Osteoarthritis condition card totals 102 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.