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Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 6 of 14
Neurodevelopmental Outcomes in Children: Strengthening the Caregiver-Child Story
Baylor College of Medicine
NCT05809115
EaseVRx-8w+ for the Treatment of Chronic Lower Back Pain
AppliedVR
NCT05263037
Intern Health Study 2024
University of Michigan
NCT06465680
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
Canadian Cancer Trials Group
NCT00819208
Modified Interactive Screening Program Plus MINDBODYSTRONG: A Mental Health Resiliency Intervention for Nurses
Ohio State University
NCT05582343
More Individualized Care: Assessment and Recovery Through Engagement
Kaiser Permanente
NCT05122676
Evaluation of a Collaborative Behavioral Health Program Implementation in Primary Care
Northwestern University
NCT04321876
PATH 2 Purpose: Primary Care and Community-Based Prevention of Mental Disorders in Adolescents
University of Illinois at Chicago
NCT04290754
Comparing Behavior Therapy and Yoga for Treating Depression Among Adults
Massachusetts General Hospital
NCT05546697
Kintsugi Voice Device Pilot Study
Kintsugi Mindful Wellness
NCT06374056
Perinatal Research on Improving Sleep and Mental Health
University of California, San Francisco
NCT05596318
Supporting Family Caregivers of Persons With Dementia
University of Pennsylvania
NCT05336344
The PATHway Study: Primary Care Based Depression Prevention in Adolescents
University of Illinois at Chicago
NCT05203198
Resettled Refugee Families for Healing
Washington University School of Medicine
NCT06176638
The Families and Middle School Success Project
University of Oregon
NCT05400564
Using Technology to Optimize Collaborative Care Management of Depression in Urban and Rural Cancer Centers, SCOPE
University of Washington
NCT05012124
Assessing an EEG Biomarker of Response to TMS for Major Depression
VA Office of Research and Development
NCT05008198
Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals
Massachusetts General Hospital
NCT01075672
Preventing Anxiety and Depression in Older Hispanics
University of Miami
NCT03870360
Improving Mental Health Among the LGBTQ+ Community
Brown University
NCT05540067
Using a Mentoring Afterschool Program to Improve Adolescent Mental Health and Physical Activity: A Pilot Study
University of Minnesota
NCT06686784
Viome Nutritional Programs to Improve Clinical Outcomes for Mental Health Conditions
Viome
NCT05563857
Factorial Optimization Trial to Test Effects of Coping Intervention Components
Arizona State University
NCT05822687
Compassion Meditation vs. Health Education for Veterans
VA Office of Research and Development
NCT04651296
The Group Risk Reduction Intervention Therapy (GRRIT) Project
University of North Carolina, Charlotte
NCT05401838
Acceptance and Commitment Therapy for Depressed People With Spinal Cord Injuries
University of South Florida
NCT06233656
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Brigham and Women's Hospital
NCT03336918
This Study Explores the Mental Health Impact of Two Akashic Records Sessions.
Rasa Healing
NCT07219914
Evaluating Process of Change in Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for Depression
University of Southern California
NCT06245096
Adaptive Messaging to Support Depression Self-Management
Northwestern University
NCT06458192
Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)
Henry Ford Health System
NCT05356364
Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study
Stanford University
NCT04663841
A Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis
University of California, San Francisco
NCT05865405
Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis
University of Alabama at Birmingham
NCT03553095
Smoking Cessation for Depressed Smokers
M.D. Anderson Cancer Center
NCT00494728
Digital Mental Health Intervention for Nonsuicidal Self-Injury in Young Adults
Northwestern University
NCT05325944
TEAM-Red, a Remotely Delivered Self-management Program for Depressed Black Women at Risk for Hypertension
Jennifer B. Levin
NCT05488782
Brief, High-dose rTMS for Depression
Medical University of South Carolina
NCT04657432
SKY Breath Intervention
University of California, San Francisco
NCT05388110
Mechanism of Action of Transcranial Magnetic Stimulation
Massachusetts General Hospital
NCT04278521
Improving Brain Stimulation Through Imaging
VA Office of Research and Development
NCT03851380
Optimizing Attentional Bias Modification
University of Texas at Tyler
NCT05816564
Individualized (fMRI-guided) TMS Treatment for Depression
University of Pennsylvania
NCT06266390
TCI-Massage Clinical Trial
The Center for Victims of Torture, United States
NCT07482358
Meditation Accelerated Brain Stimulation for Depression
University of California, San Diego
NCT04586699
An eHealth Intervention to Increase Depression Treatment Initiation and Adherence Among Veterans Referred for Mental Health Services
VA Office of Research and Development
NCT05990075
Family-Centered Treatment for Depression in Hispanic Youth
MetroHealth Medical Center
NCT05407051
Individualized Functional Connectivity Targeting in aiTBS for Depression
Brigham and Women's Hospital
NCT05680727
MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence
Michigan State University
NCT05106361
TEAMS R34 #3: Team-Based Implementation Strategy for Pediatric Depression Screening
University of California, San Diego
NCT06527196
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.