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NCT04586699 · ClinicalTrials.gov registry record · NA
Meditation Accelerated Brain Stimulation for Depression
A NA study of Depression, sponsored by University of California, San Diego.
- Active
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 2
- Study locations
NCT04586699: Active NA study of Depression, sponsored by University of California, San Diego.
NCT04586699 is a NA study of Depression that is active but no longer recruiting, run by University of California, San Diego. The registered enrollment target is 50 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (94% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04586699, a NA study of Depression, is active but no longer recruiting, sponsored by University of California, San Diego.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 2
- Study locations
Study Summary
Repetitive Transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPFC, a brain region shown to be hypo-active in depression. Unfortunately, rTMS only has low to moderate efficacy; remission rates for patients range from \~15-30% in large randomized controlled trials. The focus of this research is to develop a next-generation rTMS protocol that is guided by the basic principles underlying brain plasticity, in order to improve the efficacy of rTMS for the treatment of depression. Specifically, in this study the investigators will test rTMS paired with a depression-relevant cognitive state of internal attention.
Primary Outcome
PHQ9 depression scale
Conditions Studied
Interventions
- DEVICE Medi1TMS
- DEVICE Medi2TMS
Study Locations (2)
California
- Neuromodulation Clinic Veterans Affairs San Diego - San Diego
- UC San Diego Health Psychiatry - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2021-07-15 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What the registry record for NCT04586699 still lists
NCT04586699 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Medi1TMS is the first listed.
NCT04586699 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04586699 about?
NCT04586699 is a clinical study titled "Meditation Accelerated Brain Stimulation for Depression". Repetitive Transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPF...
What is the current status of trial NCT04586699?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2021-07-15. Estimated completion is 2026-06-30.
What conditions does trial NCT04586699 study?
This clinical trial studies the following conditions: Depression.
What interventions are being tested in trial NCT04586699?
The interventions under investigation include: Medi1TMS (DEVICE), Medi2TMS (DEVICE).
Who is sponsoring clinical trial NCT04586699?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04586699 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04586699's enrollment target sits among peer trials
50 468th of 679 higher than 199 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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