Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03851380 · ClinicalTrials.gov registry record
Improving Brain Stimulation Through Imaging
A clinical trial of Depression and Depressive Disorder, Treatment-Resistant, sponsored by VA Office of Research and Development.
- Active
- Registry status
- 54
- Enrollment target
- 1
- Study location
NCT03851380 is a study of Depression and Depressive Disorder, Treatment-Resistant that is active but no longer recruiting, run by VA Office of Research and Development. The registered enrollment target is 54 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state.
The verdict
NCT03851380, a study of Depression and Depressive Disorder, Treatment-Resistant, is active but no longer recruiting, sponsored by VA Office of Research and Development.
- ACTIVE NOT RECRUITING
- Registry status
- 54 participants
- Enrollment target
- 1
- Study location
Study Summary
Repetitive pulse transcranial magnetic stimulation (rTMS) is a noninvasive treatment that involves stimulating the brain; however, treatment benefit depends on placing a TMS coil in the correct place on the head to reach critical brain regions below. Clinicians typically use scalp-based targeting, a process in which rather than using MRI guidance to target brain regions for stimulation, they use landmarks on the scalp. Several researchers, including the investigators' lab, showed that the current scalp-based targeting techniques do not position stimulation above the correct brain region, and patients fail to respond. The investigators propose to improve clinical scalp-based targeting by comparing it to MRI guided targeting. The most common clinical population receiving rTMS therapy is depressed patients. The investigators' plan is to study the accuracy of certain scalp-based rules in patients with depression. Accurate brain stimulation targeting is critical for effective rTMS therapy. For participants who are not undergoing rTMS therapy who have COVID-19 distress, we are offering a combined home-based neuromodulation (transcranial electrical stimulation) and focused psychotherapy program dedicated to improving the same outcome measure, quality of life. Transcranial electrical stimulation (tES) stimulates the brain over a large region; however, we are able to model with brain imaging which brain regions receive the strongest stimulation. Our goal is still to examine stimulation precision, but we will test whether strength of tES in the same brain regions that rTMS is targeting will also lead to improved quality of life. We will also carefully assess whether it is possible to measure healthy functioning, an outcome in the rTMS study, because sheltering in place may reduce activities and thus distort our measure. We will also test whether our psychotherapy intervention will mitigate this effect and, if so, we may make it available to all those depressed Veterans in wh
Conditions Studied
Interventions
- BEHAVIORAL Psychological / Functional Assessment
- OTHER Structural and Functional MRI
- DEVICE Transcranial Magnetic Brain Stimulation and MR Image Guidance
- DEVICE Transcranial Electrical Stimulation (tES)
Study Locations (1)
California
- VA Palo Alto Health Care System, Palo Alto, CA - Palo Alto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2019-09-30 |
| Est. Completion | 2026-05-01 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03851380
The ClinicalTrials.gov registry entry for NCT03851380 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 54 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (93% lower). The listed sponsor is VA Office of Research and Development, which has 1,668 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Depression appearing as the primary indexed condition, and to 4 interventions - of which Psychological / Functional Assessment is the first listed.
NCT03851380 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT03851380 about?
NCT03851380 is a clinical study titled "Improving Brain Stimulation Through Imaging". Repetitive pulse transcranial magnetic stimulation (rTMS) is a noninvasive treatment that involves stimulating the brain; however, treatment benefit depends on placing a TMS coil in the correct place on the head to reach critical brain regions below. Clinicians typically use scalp-based targeting, a...
What is the current status of trial NCT03851380?
This trial is currently active not recruiting. The enrollment target is 54 participants. The study started on 2019-09-30. Estimated completion is 2026-05-01.
What conditions does trial NCT03851380 study?
This clinical trial studies the following conditions: Depression, Depressive Disorder, Treatment-Resistant, COVID Stress.
What interventions are being tested in trial NCT03851380?
The interventions under investigation include: Psychological / Functional Assessment (BEHAVIORAL), Structural and Functional MRI (OTHER), Transcranial Magnetic Brain Stimulation and MR Image Guidance (DEVICE), Transcranial Electrical Stimulation (tES) (DEVICE).
Who is sponsoring clinical trial NCT03851380?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03851380 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Reaching Out to Distressed Medical Residents, Fellows and Faculty
RECRUITING · NA
-
Depression and Driving
RECRUITING
-
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
RECRUITING · Phase 1
-
Sleep to Reduce Incident Depression Effectively in Peripartum
RECRUITING · Phase 2
-
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
RECRUITING · Phase 1
-
Identifying and Treating Depression in the Orthopaedic Trauma Population
RECRUITING · Phase 4
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.