Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,963 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,963 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Open enrollment, early-phase tilt
Depression has 687 registered US clinical trials, 245 of them open to new participants right now, about 36% of the total.
- 245
- recruiting participants now
- 36%
- of trials open to enrollment
- 70
- in Phase 3-4 (later-stage)
- 29
- top sponsor: Massachusetts General Hospital
Corpus placement: #5 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 5 of 14
Optimizing Care for Cancer Survivors With Depression: Project 3
Medical University of South Carolina
NCT06930729
Transdiagnostic Cognitive Biomarkers
University of Minnesota
NCT04864080
Acute Psychiatric Care at Home for Lower-risk Patients With Acute Psychiatric Illness Who Require Inpatient Care
Brigham and Women's Hospital
NCT07364825
Neuroscience of Psychotherapy for Depression
University of North Carolina, Chapel Hill
NCT06696001
Positive Processes and Transition to Health - Single-Session (PATH-SS)
Case Western Reserve University
NCT06900712
Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
VA Office of Research and Development
NCT06419439
CAPABLE Transplant
Johns Hopkins University
NCT06326905
Exploring Virtual Reality Adventure Training Exergaming
The University of Texas at Arlington
NCT05563805
Accelerated rTMS for Substance Use Disorder and Depression
University of Texas Southwestern Medical Center
NCT06424184
Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students
Milton S. Hershey Medical Center
NCT07240792
Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
University of Texas at Austin
NCT06523439
Bringing the Outdoors In: Virtual Nature Walks for Depression in Multiple Sclerosis (MS) Patients
University of Michigan
NCT07392879
Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
NYU Langone Health
NCT07111390
Psilocybin in Chronic Low Back Pain and Depression
Johns Hopkins University
NCT06355414
The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity
VA Office of Research and Development
NCT04953806
Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
Massachusetts General Hospital
NCT07359157
A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
Sirtsei Pharmaceuticals
NCT06570369
Readiness and Progress in Emotion Regulation Therapy
Teachers College, Columbia University
NCT07478393
Latino Teen Depression Treatment Study
Duke University
NCT05499182
A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
University of California, Los Angeles
NCT06906939
Glucose Variability and Cognition in Prediabetes
University of Maryland, Baltimore
NCT04201600
The BEAR Program for Women With Trauma Who Have Suicidal Thoughts
Stanford University
NCT07346638
Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-Life
Albany Research Institute
NCT06824532
Depression, Aging, Stress and Heart Health Study
University of North Carolina, Chapel Hill
NCT05570721
Kind Minds Program for Youth With Anxiety and Depression
University of California, Los Angeles
NCT05353751
Effects of Spirulina Supplementation on Mental Health in Healthy Adults
Arizona State University
NCT06936202
Developing and Testing an Online Pathway From Screening to Treatment for Depression in Oncology: iPath*D (Aim 2)
Dartmouth-Hitchcock Medical Center
NCT05302375
Investigating Dynamic Interactions in Distributed Cognitive Control Networks
University of Alabama at Birmingham
NCT05927974
Creatine for Depressed Male and Female Methamphetamine Users
Montana State University
NCT02568878
Lakota Family Acceptance Project
University of Michigan
NCT07326748
Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
University of Illinois at Chicago
NCT05094297
Dosing rTMS for Depression Post-SCI
VA Office of Research and Development
NCT05553353
taVNS or TMS or Both for Depression
Medical University of South Carolina
NCT05725239
Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment
Mayo Clinic
NCT07221409
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Johns Hopkins University
NCT04123314
Assessment of Music Experiences in Navigating Depression Part 2
Icahn School of Medicine at Mount Sinai
NCT07218055
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors
M.D. Anderson Cancer Center
NCT06801041
Storytelling and Mindfulness for Graduate Student Wellbeing
University of Wisconsin, Madison
NCT05826860
fMRI Accelerated TMS Depression
Medical University of South Carolina
NCT06562153
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
Mayo Clinic
NCT06038929
Suicide Specific Rumination in Veterans
VA Office of Research and Development
NCT06481033
Treatment of Depression Post-SCI
Medical University of South Carolina
NCT04263285
Buspirone and Melatonin for Depression Following Traumatic Brain Injury
Massachusetts General Hospital
NCT04400266
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
Juliana Zambrano, MD, MPH
NCT06597695
Mobile Cognitive Behavioral Therapy for Stroke
Weill Medical College of Cornell University
NCT06689878
The Community Youth Development Study: A Test of Communities That Care
University of Washington
NCT01088542
Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
Anne Murray
NCT07224347
University of North Carolina Alumni Heart Study
Duke University
NCT00005398
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
University of Texas Southwestern Medical Center
NCT06002204
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
Massachusetts General Hospital
NCT06433635
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Depression right now
245 recruiting of 687 indexed (36% open).
Phase mix: 70 late (III/IV) vs 111 early (I/II) (early-phase heavy).
Top sponsor: Massachusetts General Hospital (29 trials), 9 others listed. 50 shown below, recruiting first. #5 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Depression?
PlainTrial tracks 687 US clinical trials for Depression, of which 245 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depression?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.