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NCT05680727 · ClinicalTrials.gov registry record · Phase 2
Individualized Functional Connectivity Targeting in aiTBS for Depression
A Phase 2 study of Depression and Depressive Disorder, Major, sponsored by Brigham and Women's Hospital.
- Active
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05680727: Active Phase 2 study of Depression and Depressive Disorder, Major, sponsored by Brigham and Women's Hospital.
NCT05680727 is a Phase 2 study of Depression and Depressive Disorder, Major that is active but no longer recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 40 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05680727, a Phase 2 study of Depression and Depressive Disorder, Major, is active but no longer recruiting, sponsored by Brigham and Women's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to estimate the importance of neuroimaging in accelerated intermittent theta burst stimulation (aiTBS) for depression. Participants will receive aiTBS treatment, but they will not know if their treatment spot was found with neuroimaging or head measurements.
Primary Outcome
Depression severity rating scale (0-60, higher numbers indicate higher severity). The primary outcome measure was the baseline-adjusted MADRS score one month after treatment. The primary analysis of this primary outcome measure was the effect size of connectivity-based targeting.
Conditions Studied
Interventions
- PROCEDURE transcranial magnetic stimulation
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-07-15 |
| Est. Completion | 2027-03-17 |
| Phase | Phase 2 |
What the registry record for NCT05680727 still lists
NCT05680727 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (95% lower).
The record links to 5 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which transcranial magnetic stimulation is the first listed.
NCT05680727 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05680727 about?
NCT05680727 is a clinical study titled "Individualized Functional Connectivity Targeting in aiTBS for Depression". The goal of this clinical trial is to estimate the importance of neuroimaging in accelerated intermittent theta burst stimulation (aiTBS) for depression. Participants will receive aiTBS treatment, but they will not know if their treatment spot was found with neuroimaging or head measurements.
What is the current status of trial NCT05680727?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2023-07-15. Estimated completion is 2027-03-17.
What conditions does trial NCT05680727 study?
This clinical trial studies the following conditions: Depression, Depressive Disorder, Major, Mood Disorders, Mental Disorder, Psychiatric Disorder.
What interventions are being tested in trial NCT05680727?
The interventions under investigation include: transcranial magnetic stimulation (PROCEDURE).
Who is sponsoring clinical trial NCT05680727?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05680727 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05680727's enrollment target sits among peer trials
40 509th of 679 higher than 151 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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