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NCT00494728 · ClinicalTrials.gov registry record · Phase 1

Smoking Cessation for Depressed Smokers

A Phase 1 study of Depression and Smoking, sponsored by M.D. Anderson Cancer Center.

Active
Registry status
Phase 1
Development phase
91
Enrollment target
1
Study location

NCT00494728 is a Phase 1 study of Depression and Smoking that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 91 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT00494728, a Phase 1 study of Depression and Smoking, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
91 participants
Enrollment target
1
Study location

Study Summary

Objectives: Primary Aim: To conduct a preliminary randomized trial in smokers with current recurrent major depressive disorder (MDD), current MDD with a single episode of 2 years or more, and current dysthymia comparing combined cognitive behavioral analysis system of psychotherapy (CBASP) and standard smoking cessation treatment (ST) (CBASP/ST) to combined Health Education and ST treatment (HE/ST) to: 1\. Examine the effects of CBASP/ST on both short and long-term point prevalence abstinence Secondary Aims: 1. To test the hypothesis that depressed smokers in the CBASP/ST treatment will experience greater decreases in depressive symptoms from baseline to each of our follow-up assessment points, compared to depressed smokers in the HE/ST treatment, and; 2. That depressed smokers in the CBASP/ST treatment will experience greater improvements in psychosocial functioning from baseline to follow-up assessment points, compared to depressed smokers in the ST treatment. 3. To evaluate between subject neurophysiological predictors of abstinence at 3 and 6 months, and: 4. To evaluate within-subject changes in neurophysiological responses to emotional and smoking-related stimuli across treatment sessions, and the relation of these changes to abstinence and depressive symptoms at end of treatment, and 3- and 6-months.

Conditions Studied

Depression Smoking

Interventions

  • BEHAVIORAL Smoking Cessation Treatment
  • DRUG Nicotine Replacement Therapy
  • BEHAVIORAL CBASP

Study Locations (1)

Texas

  • University of Texas MD Anderson Cancer Center - Houston

Trial Details

FieldValue
Enrollment Target 91 participants
Start Date 2007-06-28
Est. Completion 2026-06-30
Phase Phase 1

Sponsor

M.D. Anderson Cancer Center

2,692 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00494728

The ClinicalTrials.gov registry entry for NCT00494728 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 91 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (88% lower). The listed sponsor is M.D. Anderson Cancer Center, which has 2,692 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 3 interventions - of which Smoking Cessation Treatment is the first listed.

NCT00494728 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT00494728 about?

NCT00494728 is a clinical study titled "Smoking Cessation for Depressed Smokers". Objectives: Primary Aim: To conduct a preliminary randomized trial in smokers with current recurrent major depressive disorder (MDD), current MDD with a single episode of 2 years or more, and current dysthymia comparing combined cognitive behavioral analysis system of psychotherapy (CBASP) and sta...

What is the current status of trial NCT00494728?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 91 participants. The study started on 2007-06-28. Estimated completion is 2026-06-30.

What conditions does trial NCT00494728 study?

This clinical trial studies the following conditions: Depression, Smoking.

What interventions are being tested in trial NCT00494728?

The interventions under investigation include: Smoking Cessation Treatment (BEHAVIORAL), Nicotine Replacement Therapy (DRUG), CBASP (BEHAVIORAL).

Who is sponsoring clinical trial NCT00494728?

This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00494728 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.