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NCT00494728 · ClinicalTrials.gov registry record · Phase 1
Smoking Cessation for Depressed Smokers
A Phase 1 study of Depression and Smoking, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 91
- Enrollment target
- 1
- Study location
NCT00494728: Active Phase 1 study of Depression and Smoking, sponsored by M.D. Anderson Cancer Center.
NCT00494728 is a Phase 1 study of Depression and Smoking that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 91 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00494728, a Phase 1 study of Depression and Smoking, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 91 participants
- Enrollment target
- 1
- Study location
Study Summary
Objectives: Primary Aim: To conduct a preliminary randomized trial in smokers with current recurrent major depressive disorder (MDD), current MDD with a single episode of 2 years or more, and current dysthymia comparing combined cognitive behavioral analysis system of psychotherapy (CBASP) and standard smoking cessation treatment (ST) (CBASP/ST) to combined Health Education and ST treatment (HE/ST) to: 1\. Examine the effects of CBASP/ST on both short and long-term point prevalence abstinence Secondary Aims: 1. To test the hypothesis that depressed smokers in the CBASP/ST treatment will experience greater decreases in depressive symptoms from baseline to each of our follow-up assessment points, compared to depressed smokers in the HE/ST treatment, and; 2. That depressed smokers in the CBASP/ST treatment will experience greater improvements in psychosocial functioning from baseline to follow-up assessment points, compared to depressed smokers in the ST treatment. 3. To evaluate between subject neurophysiological predictors of abstinence at 3 and 6 months, and: 4. To evaluate within-subject changes in neurophysiological responses to emotional and smoking-related stimuli across treatment sessions, and the relation of these changes to abstinence and depressive symptoms at end of treatment, and 3- and 6-months.
Conditions Studied
Interventions
- BEHAVIORAL Smoking Cessation Treatment
- DRUG Nicotine Replacement Therapy
- BEHAVIORAL CBASP
Study Locations (1)
Texas
- University of Texas MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 91 participants |
| Start Date | 2007-06-28 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 1 |
What the registry record for NCT00494728 still lists
NCT00494728 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 91 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (88% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 3 interventions - of which Smoking Cessation Treatment is the first listed.
NCT00494728 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT00494728 about?
NCT00494728 is a clinical study titled "Smoking Cessation for Depressed Smokers". Objectives: Primary Aim: To conduct a preliminary randomized trial in smokers with current recurrent major depressive disorder (MDD), current MDD with a single episode of 2 years or more, and current dysthymia comparing combined cognitive behavioral analysis system of psychotherapy (CBASP) and sta...
What is the current status of trial NCT00494728?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 91 participants. The study started on 2007-06-28. Estimated completion is 2026-06-30.
What conditions does trial NCT00494728 study?
This clinical trial studies the following conditions: Depression, Smoking.
What interventions are being tested in trial NCT00494728?
The interventions under investigation include: Smoking Cessation Treatment (BEHAVIORAL), Nicotine Replacement Therapy (DRUG), CBASP (BEHAVIORAL).
Who is sponsoring clinical trial NCT00494728?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00494728 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00494728's enrollment target sits among peer trials
91 355th of 679 higher than 324 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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