National Institute of Mental Health (NIMH)

317 total trials 237 currently recruiting 77 completed

Trial Pipeline

RECRUITING Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

NCT07169630

RECRUITING Phase 1

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

NCT07027839

RECRUITING Phase 1

PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)

NCT06920628

RECRUITING Phase 1

Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers

NCT06874205

RECRUITING Phase 1

PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

NCT06795581

RECRUITING Early Phase 1

Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers

NCT06484088

RECRUITING Phase 2

Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety

NCT06595953

RECRUITING Phase 2

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

NCT06511908

RECRUITING

Natural History of Depression, Bipolar Disorder and Suicide Risk

NCT06462196

RECRUITING Phase 1

Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial

NCT05608434

RECRUITING

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

NCT05669703

RECRUITING NA

State-dependent Interoception, Value-based Decision-making, and Introspection

NCT05666726

RECRUITING Phase 1

[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

NCT05703685

RECRUITING

Developing Brain, Impulsivity and Compulsivity

NCT04631042

RECRUITING NA

Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array

NCT04950309

RECRUITING

Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

NCT04639830

RECRUITING Phase 1

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

NCT04396873

RECRUITING

Long-term Observation of Participants With Mood Disorders

NCT04877977

RECRUITING Phase 1

PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

NCT04582916

RECRUITING NA

Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

NCT04798274

RECRUITING Phase 1

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

NCT03973268

RECRUITING

Characterization and Treatment of Adolescent Depression

NCT03388606

RECRUITING

Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

NCT03304665

RECRUITING Phase 1

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

NCT03065335

RECRUITING Phase 2

Neurobiology of Suicide

NCT02543983

RECRUITING

Psychological Treatments for Youth With Severe Irritability.

NCT02531893

RECRUITING

Brain Stimulation and Vision Testing

NCT01617408

RECRUITING

Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders

NCT01778504

RECRUITING

Top-Down Attentional Control of Visual-Processing

NCT01087281

RECRUITING

A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

NCT01434368

RECRUITING NA

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

NCT01266577

RECRUITING

Defining the Brain Phenotype of Children With Williams Syndrome

NCT01132885

RECRUITING

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

NCT00397111

RECRUITING NA

MRS Measurement of Glutamate and GABA Metabolism in Brain

NCT00109174

RECRUITING

The Neurodevelopmental and Behavioral Phenotyping Screening Protocol

NCT00271622

RECRUITING

Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

NCT00025935

RECRUITING Phase 2

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

NCT00018057

RECRUITING

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

NCT00024635

RECRUITING

Studies of Blood Flow to the Brain During Thought

NCT00001360

RECRUITING

Study of Premenstrual Syndrome and Premenstrual Dysphoria

NCT00001177

ACTIVE NOT RECRUITING NA

Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)

NCT05172271

ACTIVE NOT RECRUITING

Evaluation of the Genetics of Bipolar Disorder

NCT00001174

ACTIVE NOT RECRUITING

Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

NCT00001246

COMPLETED

Mental Health Impact of COVID-19 Pandemic on NIMH Research Participants and Volunteers

NCT04339790

COMPLETED Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome

NCT02743377

COMPLETED Phase 2

Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder

NCT02484456

COMPLETED Phase 4

Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety

NCT02153944

COMPLETED Phase 1

Evaluation of Two Radioactive Chemicals to Image mGluR5 Receptors in Brain

NCT01896843

COMPLETED

Study of [11C]DPA-713 for Temporal Lobe Epilepsy

NCT01793532

COMPLETED

(18F)FCWAY and the Blood-Brain Barrier

NCT01386476

COMPLETED

Study of Toddlers With Language Delay

NCT01339767

COMPLETED Phase 1

Brain Imaging Study of Adults With Autism Spectrum Disorders

NCT01093768

COMPLETED

Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

NCT00942981

COMPLETED

Characterizing Lone Parenting: A Multi-institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children With Cancer

NCT00969579

COMPLETED

Screening and Evaluation of Patients With Signs and Symptoms of Alzheimer's Disease

NCT00955422

COMPLETED

Development and Decline of Brain and Cognition Through the Life Span

NCT00880451

COMPLETED

Imaging Cannabinoid CB1 Receptors in Alcohol Dependence

NCT00816439

COMPLETED Phase 4

Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia

NCT00802100

COMPLETED

p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram

NCT00697268

COMPLETED Phase 4

Combining Medications to Enhance Depression Outcomes

NCT00590863

COMPLETED

Detecting Risk of Suicide in a Pediatric Emergency Department

NCT00623493

COMPLETED

PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in Frontotemporal Dementia

NCT00613119

COMPLETED Phase 1

PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [F-18]FB

NCT00527579

COMPLETED Phase 1

PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28

NCT00526916

COMPLETED Phase 1

Antidepressant Effects of NR2B in Major Depression

NCT00472576

COMPLETED Phase 1

Imaging of Cannabinoid Receptors Using New Radioactive Tracer

NCT00450021

COMPLETED Phase 1

PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28

NCT00407693

COMPLETED Phase 4

Minocycline to Treat Childhood Regressive Autism

NCT00409747

COMPLETED Phase 1

Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients

NCT00369798

COMPLETED

Identifying the Role of Oxytocin and Vasopressin in the Functioning of Neurocognitive Systems Involved in Mood Disorders

NCT00325065

COMPLETED Phase 2

Use of an Antibiotic as an Enhancer for the Treatment of Social Phobia

NCT00128401

COMPLETED

The Role of Norepinephrine in Emotional Processing

NCT00109642

COMPLETED

Role of Substance P in Post-Traumatic Stress Disorder

NCT00102102

COMPLETED Phase 1

Evaluation of Substance P Neurotransmission in Panic Disorder by PET Imaging of NK1 Receptors With [18F]SPA-RQ

NCT00088738

COMPLETED Phase 1

Rapid Antidepressant Effects of Ketamine in Major Depression

NCT00088699

COMPLETED Phase 2

Lexapro and Pramipexole and to Treat Major Depression

NCT00086307

COMPLETED

Family Study of Affective and Anxiety Spectrum Disorders

NCT00071786

COMPLETED

Serotonin Transporters in Obsessive-Compulsive-Related Disorders

NCT00082550

COMPLETED

Neurocardiac Control in Major Depression

NCT00084162

COMPLETED

FMRI Study of Performance During a Probabilistic Reversal Learning Task in Depression

NCT00075296

COMPLETED

Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder

NCT00071123

COMPLETED

Brain Regulation of Emotions in People With Depression and Anhedonia

NCT00059579

COMPLETED Phase 2

Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia

NCT00061789

COMPLETED

Brain Imaging in Depression

NCT00050700

COMPLETED Phase 3

Clinical Trial of Memantine for Major Depression

NCT00040261

COMPLETED Phase 4

Ethnic Variations in Antidepressant Response

NCT00047671

COMPLETED

Brain Imaging in Alzheimer's Disease

NCT00039702

COMPLETED

PET Scanning in Parkinson s Disease

NCT00024622

COMPLETED

Effects of Stress Hormones on Emotion and Cognition

NCT00032838

COMPLETED

Reward-Related Processes and Brain Function

NCT00029588

COMPLETED

Cortical Excitability in Obsessive-Compulsive and Related Disorders

NCT00029068

COMPLETED Phase 2

Clozapine for Treatment-Resistant Mania

NCT00029458

COMPLETED

Brain Function in Mentally Ill Adolescents

NCT00025857

COMPLETED

Adolescence, Puberty, and Emotion Regulation

NCT00016731

COMPLETED Phase 2

Clinical Trial of Propranolol for Seasonal Affective Disorder

NCT00016666

COMPLETED

Use of Transcranial Magnetic Stimulation (TMS) and Magnetic Resonance Imaging (MRI) to Study Visual Attention

NCT00006285

COMPLETED

Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study

NCT00006177

COMPLETED

Heart Disease Risk Factors in Major Depression

NCT00001969

COMPLETED

Electrophysiology and Blood Flow in Patients With Schizophrenia and Their Siblings

NCT00001921

COMPLETED

Neuroimaging of St. John's Wort-Induced Changes of Serotonin Metabolism in Normal Subjects

NCT00001919

Phase Distribution

PhaseTrial count
Phase 1 112
Phase 2 11
Phase 3 3
Phase 4 5

What the Pipeline for National Institute of Mental Health (NIMH) Shows

According to the ClinicalTrials.gov registry, National Institute of Mental Health (NIMH) is linked to 317 US clinical trials across every stage of research activity. Of those, 237 studies are currently recruiting — about 75% of the sponsor's indexed portfolio — and 77 are already marked complete, representing roughly 24% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for National Institute of Mental Health (NIMH) reports 8 late-stage studies (Phase 3 and Phase 4 combined) and 123 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for National Institute of Mental Health (NIMH) is Healthy with 21 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial