National Institute of Mental Health (NIMH)
National Institute of Mental Health (NIMH) sponsors 343 registered US clinical trials on ClinicalTrials.gov, 42 of them currently recruiting, and 256 completed. 29 of these trials are in Phase 3-4 (later-stage) and 106 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 21 trials.
Trial Pipeline
343 total, page 1 of 7
PET Imaging of Noradrenergic Transmission in the Brain
NCT07686393
Evaluation of [11C]ZTP-1 to Image PDE4B
NCT07625345
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
NCT07169630
Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)
NCT07027839
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
NCT06920628
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
NCT06874205
PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder
NCT06795581
Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers
NCT06484088
Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety
NCT06595953
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
NCT06511908
Natural History of Depression, Bipolar Disorder and Suicide Risk
NCT06462196
Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial
NCT05608434
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
NCT05669703
State-dependent Interoception, Value-based Decision-making, and Introspection
NCT05666726
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
NCT05703685
Developing Brain, Impulsivity and Compulsivity
NCT04631042
Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array
NCT04950309
Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations
NCT04639830
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
NCT04396873
Long-term Observation of Participants With Mood Disorders
NCT04877977
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
NCT04582916
Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder
NCT04798274
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
NCT03973268
Characterization and Treatment of Adolescent Depression
NCT03388606
Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies
NCT03304665
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
NCT03065335
Neurobiology of Suicide
NCT02543983
Psychological Treatments for Youth With Severe Irritability.
NCT02531893
Brain Stimulation and Vision Testing
NCT01617408
Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
NCT01778504
Top-Down Attentional Control of Visual-Processing
NCT01087281
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty
NCT01434368
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
NCT01266577
Defining the Brain Phenotype of Children With Williams Syndrome
NCT01132885
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders
NCT00397111
MRS Measurement of Glutamate and GABA Metabolism in Brain
NCT00109174
The Neurodevelopmental and Behavioral Phenotyping Screening Protocol
NCT00271622
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
NCT00025935
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
NCT00018057
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
NCT00024635
Studies of Blood Flow to the Brain During Thought
NCT00001360
Study of Premenstrual Syndrome and Premenstrual Dysphoria
NCT00001177
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
NCT05172271
Evaluation of the Genetics of Bipolar Disorder
NCT00001174
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers
NCT00001246
Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive Psychotherapy
NCT07640802
Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
NCT07566468
[11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine
NCT05522673
[18F]SF12051 for Imaging the 18-kDa Translocator Protein (TSPO) in Brain and Whole Body of Healthy Subjects
NCT05564429
PET Imaging of Cyclooxygenase in Multiple Sclerosis
NCT05062083
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 61 |
| Phase 2 | 45 |
| Phase 3 | 8 |
| Phase 4 | 21 |
Therapeutic Areas
What the Pipeline for National Institute of Mental Health (NIMH) Shows
According to the ClinicalTrials.gov registry, National Institute of Mental Health (NIMH) is linked to 343 US clinical trials across every stage of research activity. Of those, 42 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 256 are already marked complete, representing roughly 75% of the total.
The phase mix for National Institute of Mental Health (NIMH) reports 29 late-stage studies (Phase 3 and Phase 4 combined) and 106 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Institute of Mental Health (NIMH) is Healthy with 21 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.