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NCT03336918 · ClinicalTrials.gov registry record
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
A clinical trial of Depression and Bipolar Disorder, sponsored by Brigham and Women's Hospital.
- Active
- Registry status
- 120
- Enrollment target
- 1
- Study location
NCT03336918: Active study of Depression and Bipolar Disorder, sponsored by Brigham and Women's Hospital.
NCT03336918 is a study of Depression and Bipolar Disorder that is active but no longer recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 120 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03336918, a study of Depression and Bipolar Disorder, is active but no longer recruiting, sponsored by Brigham and Women's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
Primary Outcome
Investigate effects of lithium monotherapy treatment of BD on changes in Fc through fMRI imaging from baseline after 2, 8, and 26 weeks of treatment and test whether these changes correlate with improvement in state-related symptoms and longer term mood stability. Healthy controls will also be scanned at the same time points but not treated.
Conditions Studied
Interventions
- DRUG Lithium
Study Locations (1)
Ohio
- Cleveland Clinic Foundation Center for Behavioral Health - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2017-12-07 |
| Est. Completion | 2026-06-01 |
What the registry record for NCT03336918 still lists
NCT03336918 is an observational study that tracks outcomes without assigning an intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (85% lower).
The record links to 6 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which Lithium is the first listed.
NCT03336918 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT03336918 about?
NCT03336918 is a clinical study titled "Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder". Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
What is the current status of trial NCT03336918?
This trial is currently active not recruiting. The enrollment target is 120 participants. The study started on 2017-12-07. Estimated completion is 2026-06-01.
What conditions does trial NCT03336918 study?
This clinical trial studies the following conditions: Depression, Bipolar Disorder, Bipolar Depression, Major Depressive Episode, Bipolar I Depression.
What interventions are being tested in trial NCT03336918?
The interventions under investigation include: Lithium (DRUG).
Who is sponsoring clinical trial NCT03336918?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03336918 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03336918's enrollment target sits among peer trials
120 292nd of 679 higher than 379 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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