Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 7 of 14
Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
Stanford University
NCT06317636
EEG Biomarker Study for Participants in the Neurolief "MOOD" Trial
Butler Hospital
NCT05178784
Meditation Therapy in Improving Anxiety and Depression in Cancer Patients With Psychosocial Distress
M.D. Anderson Cancer Center
NCT02988271
Pain Reduction Through Empowered Recovery (PRIME) Study
Johns Hopkins University
NCT05619510
Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans
Yale University
NCT04711915
Using rTMS to Treat Depression
Florida International University
NCT05424224
A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers
M.D. Anderson Cancer Center
NCT05044546
Low Intensity Focused Ultrasound: a New Paradigm for Depression and Anxiety
Ocean State Research Institute
NCT05147142
An Idiographic Examination of Treatment Mechanisms in Emotion Regulation Therapy
Teachers College, Columbia University
NCT05590741
Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment
M.D. Anderson Cancer Center
NCT03519451
Altering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive Symptoms
University of Arizona
NCT06320028
Focused Ultrasound Amygdala Neuromodulation
University of Texas at Austin
NCT05228964
Autonomous Digital CBT Intervention for Opioid Use Disorder in Individuals With Co-Occurring Internalizing Disorders
University of Minnesota
NCT06545071
A Neuroimaging Study of Open-label Placebo in Depressed Adolescents
University of California, San Francisco
NCT04201106
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Icahn School of Medicine at Mount Sinai
NCT06069843
Adapting BA for Minimally Verbal Autistic Adults
Rutgers, The State University of New Jersey
NCT06064422
PRISM for Depression and Anxiety in Young Adults With Cancer
Dana-Farber Cancer Institute
NCT06502483
Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders
University of Arizona
NCT03540745
Anxiety and Depression Levels in Cancer Patients After Self-Application of EFT (Emotional Freedom Techniques)
Soul Medicine Institute
NCT00737399
Testing a Transdiagnostic TMS Treatment Target
Brigham and Women's Hospital
NCT06282146
Implementation of Collaborative Care for Depression in VA HIV Clinics
VA Office of Research and Development
NCT05901272
Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes
M.D. Anderson Cancer Center
NCT04743466
Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
University of California, San Francisco
NCT03217058
Cooking for Health Optimization With Patients
Tulane University
NCT03443635
Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic
Pregistry
NCT04385238
Mental Health Pathways in Internet Support Groups
Carnegie Mellon University
NCT02396472
SSIs for Mental Health and Loneliness
University of California, Irvine
NCT05687162
Long Term Health Outcomes of Women Veterans' Service During the Vietnam Era
VA Office of Research and Development
NCT00958061
National Child Traumatic Stress Network (NCTSN) Quality Improvement Initiative Database
Hugo W. Moser Research Institute at Kennedy Krieger
NCT01591694
Intern Health Study 2022 and 2023
University of Michigan
NCT05436145
Providing Mental Health Precision Treatment
University of Michigan
NCT04342494
Multimedia Educational Program for Patients With Early-Stage Prostate Cancer or Breast Cancer
University of Colorado, Denver
NCT00830635
A Smartphone Intervention for Relational and Mental Well Being
University of Washington
NCT04629755
Diabetes-Depression Care-management Adoption Trial
University of Southern California
NCT01781013
Evaluating the Effects of Stress in Pregnancy
Emory University
NCT00525226
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
University of New Hampshire
NCT03488927
Community Partners in Care is a Research Project Funded by the National Institutes of Health
RAND
NCT01699789
Study of a Holistic Health Program for United Methodist Clergy
Duke Clergy Health Initiative
NCT01564719
Efficacy and Safety of Fixed Doses of BMS 820836 in the Treatment of Patients With Treatment Resistant Major Depression
Bristol-Myers Squibb
NCT01369095
Determine The Percentage Of Depressed Outpatients Who Do Not Effectively Metabolize Extended-release Venlafaxine HCl
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00788944
Activating Messages for Enhancing Primary Care Practice (AMEP2): Effectiveness Study
University of California, Davis
NCT01144104
Open-Label Safety Study of AXS-05 in Subjects With Depression
Axsome Therapeutics
NCT04039022
Mobile Mental Health Apps for Suicide Prevention
University of Washington
NCT04536935
Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress
Otsuka Pharmaceutical Development & Commercialization
NCT02196506
Enhancing Recovery After Cardiac Surgery
University of California, Los Angeles
NCT00522717
Collaborative Care to Reduce Depression and Increase Cancer Screening Among Low-Income Urban Women
Clinical Directors Network
NCT02273206
Relapse-Prevention Study With Levomilnacipran ER (F2695 SR) in Patients With Major Depressive Disorder
Forest Laboratories
NCT01085812
Sleep Signal Analysis for Current Major Depressive Episode (SAMDE)
Medibio Limited
NCT05708222
Online Positive Emotion Skills Intervention for Symptoms of Depression
Northwestern University
NCT02861755
Seroquel in Bipolar Depression Versus SSRI
AstraZeneca
NCT00119652
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.